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Helicobacter pylori infection and type 1 diabetes mellitus in children

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Abstract

Objectives

This study aimed to investigate the association between Helicobacter pylori infection with diabetes mellitus type one and the effect of infected Helicobacter pylori on glycemic control.

Methods

This case control study was conducted on children with and without type 1 diabetes mellitus (T1DM). Demographic data and gastrointestinal symptoms in both groups and glycemic control status and duration of diabetes were recorded in patients with T1DM. Stool test was done on all children to detect Helicobacter pylori antigen.

Results

Sixty three children with T1DM with a mean of 10.88 ± 2.84 years and 105 control children with an average age 10.17 ± 2.55 years (P = 0/09) were involved in this study. The frequency of Helicobacter pylori infection in patients with T1DM was 17/63 (27%) and 25/105 (23.8%) in control group, (P = 0/64). The frequency of bloating, epigastric pain and nausea was not significantly different between the two groups. The frequency of epigastric pain in children with diabetes with helicobacter infection was significantly higher than non-infected children with diabetes (29.4% vs. 2.2%) (P = 0.004).The mean duration of diabetes (P = 0.53), age diagnosis of diabetes (P = 0.09), fasting blood glucose (P = 0.18), glycosylated hemoglobin (P = 0.08) and the daily insulin dose (P = 0.18) in patients with T1DM with and without helicobacter pylori infection had not significantly different.

Conclusions

There was no significant association between Helicobacter pylori infection and diabetes in children 5–15 years old, and glycemic control status was not difference in patients with T1DM with and without Helicobacter pylori infection.

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Acknowledgements

The authors wish to express their gratitude to the Clinical Research Development Unit of Amirkola Children’s Hospital and the Research Council and Non-Communicable Pediatric Diseases Research Center of Babol University of Medical Sciences for their contribution to this project.

Funding

This study is part of the doctoral dissertation of Dr. Negar Noushiravan and was supported by a research grant from the Non-Communicable Pediatric Diseases Research Center of Babol University of Medical Sciences (Grant Number: 9339615).

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Authors and Affiliations

  1. Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IR, Iran

    Mohammad Reza Esmaeili Dooki, Morteza Alijanpour Aghamaleki, Leila Moslemi & Mahmoud Hajiahmadi

  2. Non-Communicable Pediatric Diseases Research Center, Amirkola Children’s Hospital, No 19, Amirkola, Babol, Mazandaran Province, 47317-41151 IR, Iran

    Morteza Alijanpour Aghamaleki

  3. Student Research Committee, Health Research Institute, Babol University of Medical Sciences, Babol, IR, Iran

    Negar Noushiravani

  4. Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IR, Iran

    Seyed Reza Hosseini

  5. Health Reproductive Research Center, Sari Branch, Islamic Azad University, Sari, IR, Iran

    Leila Moslemi

  6. The Clinical Research Development Unit of Amirkola Children’s Hospital, Babol University of Medical Sciences, Babol, IR, Iran

    Mohammad Pournasrollah

Authors
  1. Mohammad Reza Esmaeili Dooki
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  2. Morteza Alijanpour Aghamaleki
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  3. Negar Noushiravani
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  4. Seyed Reza Hosseini
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  5. Leila Moslemi
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  6. Mahmoud Hajiahmadi
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  7. Mohammad Pournasrollah
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Correspondence to Morteza Alijanpour Aghamaleki.

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Esmaeili Dooki, M.R., Alijanpour Aghamaleki, M., Noushiravani, N. et al. Helicobacter pylori infection and type 1 diabetes mellitus in children. J Diabetes Metab Disord 19, 243–247 (2020). https://doi.org/10.1007/s40200-020-00497-1

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  • DOI: https://doi.org/10.1007/s40200-020-00497-1

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