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KCNQ1 common genetic variant and type 2 diabetes mellitus risk

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Journal of Diabetes & Metabolic Disorders Aims and scope Submit manuscript

Abstract

Background

Type 2 diabetes mellitus (T2DM) is a multifactorial trait that both environmental and genetic factors contribute to its pathogenesis. The most common single nucleotide polymorphism (SNP) of the potassium voltage-gated channel subfamily Q member 1 (KCNQ1) gene, rs2237892, is highly associated with the risk of T2DM. The aim of the present study was to examine any association between KCNQ1 gene rs2237892 variant and risk of T2DM in a group of Iranian patients.

Methods

Genotyping was carried out in 100 type 2 diabetic patients and 100 non-diabetic subjects using the Sanger sequencing method.

Results

The CC genotype caused more than 30% reduction in the risk of T2DM in compared with CT. Nonetheless, this association was not statistically significant and this variant had no protective effect for T2DM. A significant difference was not found in genotypes (CC, CT, and TT) and alleles (C and T) frequency of KCNQ1 rs2237892 SNP between T2DM and control groups (P = 0.475 and P = 0.470, respectively).

Conclusions

Our investigations did not show enough evidence for the presence of an association between KCNQ1 gene rs2237892 polymorphism and risk of T2DM among a group of Iranian patients.

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Abbreviations

T2DM:

type 2 diabetes mellitus

GWAS:

genome-wide association studies

KCNQ1 :

potassium voltage-gated channel subfamily Q member 1

ADA:

American Diabetes Association

FPG:

Fasting Plasma Glucose

OGTT:

Oral Glucose Tolerance Test

HbA1c:

Hemoglobin A1C

PCR:

Polymerase Chain Reaction

OR:

Odds Ratio

CI:

Confidence Interval

SD:

Standard Deviation

BMI:

body mass index

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Acknowledgments

The authors would like to thank all subjects who involved in this study.

Author information

Authors and Affiliations

  1. Medical Genomics Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

    Taraneh Erfani & Mandana Hasanzad

  2. Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Negar Sarhangi, Hamid Reza Aghaei Meybodi & Mandana Hasanzad

  3. Department of Community Medicine, Zabol University of Medical Sciences, Zabol, Iran

    Mahdi Afshari

  4. Iranian Diabetes Society, Eslamshahr, Iran

    Davood Abbasi

Authors
  1. Taraneh Erfani
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  2. Negar Sarhangi
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  3. Mahdi Afshari
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  4. Davood Abbasi
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  5. Hamid Reza Aghaei Meybodi
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  6. Mandana Hasanzad
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Contributions

Taraneh Erfani: technical Genetic laboratory; Negar Sarhangi: writing the first draft of manuscript; Mahdi Afshari: statistical analysis; Davood Abbasi: sample collection; Hamid Reza Aghaei Maybodi: designed the clinical study; Mandana Hasanzad: designed the Genetic study, developed the project, reviewed and revised the manuscript. All authors will read and approved the final manuscript before submission.

Corresponding author

Correspondence to Mandana Hasanzad.

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Erfani, T., Sarhangi, N., Afshari, M. et al. KCNQ1 common genetic variant and type 2 diabetes mellitus risk. J Diabetes Metab Disord 19, 47–51 (2020). https://doi.org/10.1007/s40200-019-00473-4

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  • DOI: https://doi.org/10.1007/s40200-019-00473-4

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