Journal of Diabetes & Metabolic Disorders

, Volume 18, Issue 1, pp 263–265 | Cite as

Neuromodulatory effect of microbiome on gut-brain axis; new target for obesity drugs

  • Hanieh-Sadat Ejtahed
  • Shirin Hasani-RanjbarEmail author


Considering the increasing prevalence of obesity worldwide, new approaches for its control have been investigated. Recent evidences highlighted the role of the gut microbiome in weight management. Obesity-associated gut microbiota alters host energy uptake, insulin sensitivity, inflammation, and fat storage. Moreover, the gut microbiota-derived metabolites could control appetite directly by affecting the central nervous system or indirectly through modifying the gut hormones secretion. Metabolites of the gut microbiome-brain axis could be novel targets for designing drugs in obesity. They can be prescribed directly like butyrate or can be modulated by manipulating the gut microbiota through probiotics, prebiotics and other dietary components such as polyphenols. Microbiome studies are trying to identify novel microbial species as next-generation probiotics to restore healthy gut microbiota composition and combat obesity and its related complications. According to the relationships between the gut microbiota and microbial composition of other parts of the body, the mechanisms linking the gut-brain axis and the whole human microbiota should be elucidated to provide novel anti-obesity strategies.


Obesity Human microbiota Gut-brain axis Metabolites 


Authors’ contributions

HE drafted the manuscript. SH designed the study and helped to draft the manuscript. Both authors read and approved the final manuscript.

Compliance with ethical standards

Competing interests

The authors declare that they have no competing interests.

Consent for publication

Not applicable.

Ethics approval and consent to participate

Not applicable.


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Obesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences InstituteTehran University of Medical SciencesTehranIran
  2. 2.Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences InstituteTehran University of Medical SciencesTehranIran

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