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Exploring the bi-directional relationship between pancreatic cancer and diabetes mellitus: a retrospective study

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A Correction to this article was published on 02 September 2019

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Abstract

Objective

To explore the bi-directional between pancreatic cancer (PC) and diabetes mellitus (DM); focusing on the prevalence, temporal association and impact on survival outcomes.

Methods

A retrospective audit of pancreatic cancer patients from the institutional clinical database (CaNISC) between January 2012 and April 2018.

Results

A total of 131 patients were analysed, 58 patients carried a diagnosis of diabetes mellitus. The median overall survival for diabetes mellitus patients was 12.0 months (95 CI, 5.9 to 18.1 months) in comparison to 13.0 months (95% CI, 8.6 to 17.3 months) in non-diabetes mellitus patients (p = 0.334).

Conclusion

There was no significant difference in the overall survival between DM and non-DM patients.

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Change history

  • 02 September 2019

    Author names were incorrectly displayed in the original article.

References

  1. Welsh Cancer Intelligence and Surveillance Unit | Cancer Mortality in Wales. Wcisu.wales.nhs.uk. 2018. [Accessed 24 Apr 2018] Available from: http://www.wcisu.wales.nhs.uk/cancer-mortality-in-wales

  2. Welsh Cancer Intelligence and Surveillance Unit | Cancer Survival in Wales. Wcisu.wales.nhs.uk. 2018. [Accessed 24 Apr 2018] Available from: http://www.wcisu.wales.nhs.uk/cancer-survival-in-wales-1

  3. Welsh Cancer Intelligence and Surveillance Unit | Cancer incidence by stage at diagnosis in Wales. Wcisu.wales.nhs.uk. 2018. [Accessed 24 Apr 2018] Available from: http://www.wcisu.wales.nhs.uk/cancer-incidence-by-stage-at-diagnosis-i-1

  4. Hart P, Chari S. Diabetes mellitus and pancreatic Cancer. Pancreas. 2013;42(8):1207–9.

    Article  PubMed  Google Scholar 

  5. Dandona M, Linehan D, Hawkins W, Strasberg S, Gao F, Wang-Gillam A. Influence of obesity and other risk factors on survival outcomes in patients undergoing Pancreaticoduodenectomy for pancreatic Cancer. Pancreas. 2011;40(6):931–7.

    Article  PubMed  Google Scholar 

  6. Hwang A, Narayan V, Yang Y. Type 2 diabetes mellitus and survival in pancreatic adenocarcinoma. Cancer. 2012;119(2):404–10.

    Article  PubMed  Google Scholar 

  7. McWilliams R, Matsumoto M, Burch P, Kim G, Halfdanarson T, de Andrade M, et al. Obesity adversely affects survival in pancreatic cancer patients. Cancer. 2010;116(21):5054–62.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Mao Y, Tao M, Jia X, Xu H, Chen K, Tang H, et al. Effect of Diabetes Mellitus on Survival in Patients with Pancreatic Cancer: A Systematic Review and Meta-analysis. Sci Rep. 2015;5(1).

  9. Beg M, Dwivedi A, Ahmad S, Ali S, Olowokure O. Impact of diabetes mellitus on the outcome of pancreatic Cancer. PLoS One. 2014;9(5):e98511.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Choi Y, Kim T, Oh D, Lee K, Han S, Im S, et al. The impact of diabetes mellitus and metformin treatment on survival of patients with advanced pancreatic Cancer undergoing chemotherapy. Cancer Res Treat. 2016;48(1):171–9.

    Article  CAS  PubMed  Google Scholar 

  11. Sadeghi N, Abbruzzese J, Yeung S, Hassan M, Li D. Metformin use is associated with better survival of diabetic patients with pancreatic Cancer. Clin Cancer Res. 2012;18(10):2905–12.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Radulovic S, Nagy A, Szoke B, Schally A. Cytotoxic analog of somatostatin containing methotrexate inhibits growth of MIA PaCa-2 human pancreatic cancer xenografts in nude mice. Cancer Lett. 1992;62(3):263–71.

    Article  CAS  PubMed  Google Scholar 

  13. Bowker S, Majumdar S, Veugelers P, Johnson J. Increased Cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin: response to Farooki and Schneider. Diabetes Care. 2006;29(8):1990–1.

    Article  PubMed  Google Scholar 

  14. Toriola A, Stolzenberg-Solomon R, Dalidowitz L, Linehan D, Colditz G. Diabetes and pancreatic cancer survival: a prospective cohort-based study. Br J Cancer. 2014;111(1):181–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Wang J, Shen H, Zhan M, Wang W, Yang D. Impact of diabetes mellitus on the survival of pancreatic cancer: a meta-analysis. OncoTargets Ther. 2016;9:1679–88. https://doi.org/10.2147/OTT.S95744.eCollection2016

  16. Fisher W, Boros L, Schirmer W. Insulin promotes pancreatic Cancer: evidence for endocrine influence on exocrine pancreatic tumors. J Surg Res. 1996;63(1):310–3.

    Article  CAS  PubMed  Google Scholar 

  17. Aggarwal G, Ramachandran V, Javeed N, Arumugam T, Dutta S, Klee G, et al. Adrenomedullin is up-regulated in patients with pancreatic Cancer and causes insulin resistance in β cells and mice. Gastroenterology. 2012;143(6):1510–1517e1.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Bao Y, Giovannucci E, Kraft P, Stampfer M, Ogino S, Ma J, et al. A prospective study of plasma adiponectin and pancreatic Cancer risk in five US cohorts. JNCI: J Natl Cancer Inst. 2012;105(2):95–103.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

University of Cardiff Medical School, Velindre Cancer Centre.

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Correspondence to Yim Kein-Leong.

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Conflict of interest

Harry Kellam: No conflict of interest to declare.

Kein-Leong Yim: No conflict of interest to declare.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the South Wales Ethics committee.

Informed consent

As this retrospective study was observational and link anonymised, no patient informed consent was required.

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Harry, K., Kein-Leong, Y. Exploring the bi-directional relationship between pancreatic cancer and diabetes mellitus: a retrospective study. J Diabetes Metab Disord 17, 247–252 (2018). https://doi.org/10.1007/s40200-018-0366-2

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  • DOI: https://doi.org/10.1007/s40200-018-0366-2

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