Nigella sativa (NS) is a known medicinal herb with numerous therapeutic effects such as antidiabetic, anti-proliferative, anti-inflammatory, and anti-cancer activities. It has been indicated that NS can regulate cellular metabolism by adjusting transduction signaling pathways. Adenosine monophosphate-activated protein kinase (AMPK) is one of the main physiological processes, such as energy hemostasis, cellular metabolism, and autophagy regulators. Herb-derived medicines have always been considered as one of the main AMPK activators, and surprisingly recent data has demonstrated that it can be a target for NS and its derivatives.
The literature search was conducted in PubMed, SCOPUS, Embase, ProQuest, and Google Scholar electronic resources. Published articles up to September 2020 were considered, and those of which investigated Nigella sativa effects on the AMPK pathway after meeting the inclusion criteria were included.
The search was performed on several online databases such as PubMed, Scopus, Embase, ProQuest, and Google Scholar from inception until January 2020. Among the initial search, 245 studies were found. After removing duplicated data and meeting the inclusion criteria, only 14 studies were selected. They included the effects of NS and its bioactive compounds as anti-hyperglycemic (n = 5), on liver function (n = 4), cancers (n = 3), and on Neuroinflammation and Atherosclerosis (n = 2). Most of the included studies are animals or in-vitro investigations.
In this review, we discuss the latest findings on the molecular mechanism of NS effecting the AMPK signaling pathway. We also focus on the therapeutic effects of NS, including the prevention and treatment of metabolic and pro-inflammatory disease by targeting the AMPK pathway.
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- ACC :
- AKT :
protein kinase B
- ALD :
alcoholic liver disease
- AMPK :
AMP-activated protein kinase
- EMT :
- ERK :
extracellular signal-regulated kinases
- FOXO :
Forkhead box protein O1
- GLUT-4 :
Glucose transporter type 4
- HSCs :
Hepatic stellate cells
- LKB1 :
Liver kinase B1
- mTOR :
mammalian target of rapamycin
- NF-kB :
nuclear factor kappa-light-chain-enhancer of activated B
- NS :
- PGC-1 :
Proliferator-Activated Receptor-Gamma Coactivator-1
- PPAR :
Peroxisome Proliferator-Activated Receptor
- RCC :
Renal carcinoma cells
- ROS :
Reactive oxygen species
- SIRT1 :
- TGF-B :
Transforming growth factor-beta
- TLR4 :
Toll-like receptor 4
- TQ :
- VSMCs :
Vascular Smooth Muscle Cell
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The authors would like to thank the Nutrition Research Center of Tabriz University of Medical Sciences for their support.
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Tavakoli-Rouzbehani, O.M., Maleki, V., Shadnoush, M. et al. A comprehensive insight into potential roles of Nigella sativa on diseases by targeting AMP-activated protein kinase: a review. DARU J Pharm Sci 28, 779–787 (2020). https://doi.org/10.1007/s40199-020-00376-3
- Nigella sativa
- AMP-activated protein kinase