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Therapeutic application of Carica papaya leaf extract in the management of human diseases

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Abstract

Introduction

Papaya (Carica papaya Linn.) belongs to the family Caricaceae and is well known for its therapeutic and nutritional properties all over the world. The different parts of the papaya plant have been used since ancient times for its therapeutic applications. Herein, we aimed to review the anticancer, anti-inflammatory, antidiabetic and antiviral activities of papaya leaf.

Methods

All information presented in this review article regarding the therapeutic application of Carica papaya leaf extract has been acquired by approaching various electronic databases, including Scopus, Google scholar, Web of science, and PubMed. The keywords Carica papaya, anticancer, anti-inflammatory, immunomodulatory, and phytochemicals were explored until December 2019.

Results

The papaya plant, including fruit, leaf, seed, bark, latex, and their ingredients play a major role in the management of disease progression. Carica papaya leaf contains active components such as alkaloids, glycosides, tannins, saponins, and flavonoids, which are responsible for its medicinal activity. Additionally, the leaf juice of papaya increases the platelet counts in people suffering from dengue fever.

Conclusion

The major findings revealed that papaya leaf extract has strong medicinal properties such as antibacterial, antiviral, antitumor, hypoglycaemic and anti-inflammatory activity. Furthermore, clinical trials are needed to explore the medicative potential of papaya leaf.

Graphical abstract showing the medicinal properties of Carica papaya leaf

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Acknowledgements

The Preparation of this review was financial supported by ICMR; Government of India to Surya Pratap Singh in the form of SRF (No.45/18/2018/BMS/TRM) is greatly acknowledged.

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Authors and Affiliations

  1. Department of Zoology, Banaras Hindu University, Varanasi, UP, India

    Surya P. Singh, Munendra Singh Tomar, Rishi Kant Singh, Praveen Kumar Verma, Amit Kumar, Sandeep Kumar & Arbind Acharya

  2. Cancer and Radiation Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India

    Sanjay Kumar, Sivapar V. Mathan & Rana P. Singh

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  1. Surya P. Singh
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  2. Sanjay Kumar
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Singh, S.P., Kumar, S., Mathan, S.V. et al. Therapeutic application of Carica papaya leaf extract in the management of human diseases. DARU J Pharm Sci 28, 735–744 (2020). https://doi.org/10.1007/s40199-020-00348-7

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