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Polyphenols for diabetes associated neuropathy: Pharmacological targets and clinical perspective

DARU Journal of Pharmaceutical Sciences volume 27, pages 781–798 (2019)Cite this article

Abstract

Objectives

Diabetic neuropathy (DNP) is a widespread and debilitating complication with complex pathophysiology that is caused by neuronal dysfunction in diabetic patients. Conventional therapeutics for DNP are quite challenging due to their serious adverse effects. Hence, there is a need to investigate novel effective and safe options. The novelty of the present study was to provide available therapeutic approaches, emerging molecular mechanisms, signaling pathways and future directions of DNP as well as polyphenols’ effect, which accordingly, give new insights for paving the way for novel treatments in DNP.

Evidence acquisition

A comprehensive review was done in electronic databases including Medline, PubMed, Web of Science, Scopus, national database (Irandoc and SID), and related articles regarding metabolic pathways on the pathogenesis of DNP as well as the polyphenols’ effect. The keywords “diabetic neuropathy” and “diabetes mellitus” in the title/abstract and “polyphenol” in the whole text were used. Data were collected from inception until May 2019.

Results

DNP complications is mostly related to a poor glycemic control and metabolic imbalances mainly inflammation and oxidative stress. Several signaling and molecular pathways play key roles in the pathogenesis and progression of DNP. Among natural entities, polyphenols are suggested as multi-target alternatives affecting most of these pathogenesis mechanisms in DNP.

Conclusion

The findings revealed novel pathogenicity signaling pathways of DNP and affirmed the auspicious role of polyphenols to tackle these destructive pathways in order to prevent, manage, and treat various diseases.

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Affiliations

  1. Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Rozita Naseri

  2. Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Fatemeh Farzaei, Sajad Fakhri & Mohammad Hosein Farzaei

  3. Biochemistry division, Chemistry Department, Faculty of Science, Mansoura University, Mansoura, 35516, Egypt

    Fardous F. El-Senduny

  4. Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt

    Miram Altouhamy

  5. Department of Pharmacy in Persian Medicine, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Roodabeh Bahramsoltani & Roja Rahimi

  6. PhytoPharmacology Interest Group (PPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran

    Roodabeh Bahramsoltani & Roja Rahimi

  7. Pharmacy students` research committee, School of pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran

    Farnaz Ebrahimi

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  1. Rozita Naseri
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Naseri, R., Farzaei, F., Fakhri, S. et al. Polyphenols for diabetes associated neuropathy: Pharmacological targets and clinical perspective. DARU J Pharm Sci 27, 781–798 (2019). https://doi.org/10.1007/s40199-019-00289-w

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Keywords

  • Diabetic neuropathy
  • Polyphenols
  • Therapeutic targets
  • Signaling pathways