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Human Molecular Neurocytogenetics

  • Cytogenetics (T Liehr, Section Editor)
  • Published:
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Abstract

Purpose of Review

During the last decade, genomics has delivered basic insight into somatic genome variations contributing to human neuronal diversity in health and disease. Here, we review research on somatic chromosomal mosaicism and chromosome instability in the developing and adult (normal and diseased) human brain, representing the emerging field of molecular neurocytogenetics.

Recent Findings

Chromosome instability and somatic chromosomal mosaicism were found to be involved in human brain development. Additionally, recent studies have highlighted the impact of neuronal aneuploidy and brain-specific chromosome instability on normal and pathological neurodevelopment and brain aging.

Summary

Neurocytogenomic variations are nowadays thought to play a critical role in human brain development and aging. Chromosome instability is likely to be an element of pathogenetic cascades in a variety of brain diseases. Future studies are likely to reveal new neurocytogenetic/neurocytogenomic mechanisms for formation of human neuronal diversity and mental illness. Finally, human molecular neurocytogenetics may be recognized as an integral component of current biomedical science.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major Importance

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Acknowledgements

The review is dedicated to Dr. Ilia V. Soloviev. Supported by RFBR and CITMA according to the research project №18-515-34005.

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Authors and Affiliations

  1. Yurov’s Laboratory of Molecular Genetics and Cytogenomics of the Brain, Mental Health Research Center, Zagorodnoe shosse 2/16, 117152, Moscow, Russia

    Yuri B. Yurov, Svetlana G. Vorsanova & Ivan Y. Iourov

  2. Laboratory of Molecular Cytogenetics of Neuropsychiatric Diseases, Veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University, Moscow, Russia

    Yuri B. Yurov, Svetlana G. Vorsanova & Ivan Y. Iourov

  3. Department of Medical Genetics, Russian Medical Academy of Continuous Professional Education, Moscow, Russia

    Ivan Y. Iourov

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  1. Yuri B. Yurov
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  2. Svetlana G. Vorsanova
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  3. Ivan Y. Iourov
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Correspondence to Ivan Y. Iourov.

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Yurov, Y.B., Vorsanova, S.G. & Iourov, I.Y. Human Molecular Neurocytogenetics. Curr Genet Med Rep 6, 155–164 (2018). https://doi.org/10.1007/s40142-018-0152-y

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