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Current Genetic Medicine Reports

, Volume 4, Issue 4, pp 163–169 | Cite as

Tissue Specificity of Gene Expression

  • François Aguet
  • Kristin G. ArdlieEmail author
Genomics (S Williams, Section Editor)
  • 184 Downloads
Part of the following topical collections:
  1. Genomics

Abstract

Tissue-specific patterns of gene expression are fundamental to establishing and preserving tissue identity and function, and dysregulation of these patterns underlies a wide range of diseases. Over the past few years, several large-scale efforts driven by the advent of RNA sequencing have established resources of gene expression measurements, across both tissues and individuals, toward building a comprehensive understanding of the specificity and variability of gene expression. We summarize these resources, review insights gained into the tissue specificity of gene expression across transcript classes, including protein-coding and non-coding RNAs, and discuss the developments that will be needed to integrate existing and new resources into a detailed map of gene expression and its regulation across the human body.

Keywords

Gene expression Tissue specificity RNA-seq Human transcriptome Genomic resources 

Notes

Compliance with Ethical Guidelines

Conflict of Interest

François Aguet and Kristin G. Ardlie declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Copyright information

© Springer Science + Business Media New York 2016

Authors and Affiliations

  1. 1.Broad Institute of MIT and HarvardCambridgeUSA

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