Tissue Specificity of Gene Expression
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Tissue-specific patterns of gene expression are fundamental to establishing and preserving tissue identity and function, and dysregulation of these patterns underlies a wide range of diseases. Over the past few years, several large-scale efforts driven by the advent of RNA sequencing have established resources of gene expression measurements, across both tissues and individuals, toward building a comprehensive understanding of the specificity and variability of gene expression. We summarize these resources, review insights gained into the tissue specificity of gene expression across transcript classes, including protein-coding and non-coding RNAs, and discuss the developments that will be needed to integrate existing and new resources into a detailed map of gene expression and its regulation across the human body.
KeywordsGene expression Tissue specificity RNA-seq Human transcriptome Genomic resources
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Conflict of Interest
François Aguet and Kristin G. Ardlie declare that they have no conflict of interest.
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