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Current Genetic Medicine Reports

, Volume 3, Issue 4, pp 191–195 | Cite as

Genetics and Pathology of Chronic Traumatic Encephalopathy

  • Laura L. Krafjack
  • Ramesh RaghupathiEmail author
Neurogenetics and Psychiatric Genetics (M Hiltunen & DR Marenda, Section Editors)
Part of the following topical collections:
  1. Neurogenetics and Psychiatric Genetics

Introduction

Chronic traumatic encephalopathy (CTE), characterized by the presence of neurofibrillary and astrocytic tangles composed of hyperphosphorylated tau, is believed to be one of the pathological consequences of repetitive traumatic brain injury (TBI). CTE has been diagnosed post-mortem in numerous individuals, including professional boxers and American football players, with a history of repetitive TBI [1, 2••, 3, 4, 5, 6, 7]. Concomitant with the identification of these neurofibrillary and astrocytic tangles are retrospective reports from family members and friends of these individuals of memory problems and personality changes, suggesting that the observed pathological changes may underlie the reported behavioral changes. Multiple animal models have been developed to further explore how repetitive TBI results in these pathological findings and whether these alterations underlie behavioral changes.

Defining CTE and Limitations of Diagnosis

As more cases of CTE are identified,...

Keywords

Traumatic Brain Injury Amyotrophic Lateral Sclerosis Chronic Traumatic Encephalopathy Traumatic Brain Injury Model American Football Player 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

The support was received, in part, from grants from the National Institutes of Neurologic Disorders and Stroke (NS 065017) and National Institutes of Child Health and Development (NS 069163).

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Copyright information

© Springer Science + Business Media New York 2015

Authors and Affiliations

  1. 1.Program in NeuroscienceDrexel University College of MedicinePhiladelphiaUSA
  2. 2.Department of Neurobiology and AnatomyDrexel University College of MedicinePhiladelphiaUSA
  3. 3.Coatesville Veteran’s Administration Medical CenterCoatesvilleUSA

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