Skip to main content

Advertisement

Log in

Safe Injectate Choice, Visualization, and Delivery for Lumbar Transforaminal Epidural Steroid Injections: Evolving Literature and Considerations

  • Musculoskeletal Rehabilitation (B Schneider, Section Editor)
  • Published:
Current Physical Medicine and Rehabilitation Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Lumbar transforaminal epidural steroid injection (TFESI) is a widely used treatment for lumbar radicular pain refractory to conservative care. However, rare but serious risks exist. This article summarizes the recent literature regarding considerations relevant to safe performance of TFESIs.

Recent Findings

We collated recent case report reporting of permanent neurologic injury after TFESI, which has been theorized to occur as a result of disrupted radiculomedullary arterial blood flow to the spinal cord. We also review how injectate selection, visualization methods, and delivery techniques may impact the safety considerations of these injections.

Summary

While TFESIs are safe, there is continued need to optimize injectate selection, visualization methods, and delivery techniques to minimize the possibility of complications while maintaining clinical effectiveness.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Hoy D, March L, Brooks P, Blyth F, Woolf A, Bain C, et al. The global burden of low back pain: estimates from the Global Burden of Disease 2010 study. Ann Rheum Dis. 2014;73:968–74.

    Article  PubMed  Google Scholar 

  2. Ravindra VM, Senglaub SS, Rattani A, Dewan MC, Härtl R, Bisson E, et al. Degenerative lumbar spine disease: estimating global incidence and worldwide volume. Glob Spine J. 2018;8:784–94.

    Article  Google Scholar 

  3. Friedly J, Chan L, Deyo R. Increases in lumbosacral injections in the Medicare population: 1994 to 2001. Spine. 2007;32:1754–60.

    Article  PubMed  Google Scholar 

  4. Cuellar JM, Golish SR, Reuter MW, Cuellar VG, Angst MS, Carragee EJ, et al. Cytokine evaluation in individuals with low back pain using discographic lavage. Spine J Off J North Am Spine Soc. 2010;10:212–8.

    Article  Google Scholar 

  5. Johansson A, Hao J, Sjölund B. Local corticosteroid application blocks transmission in normal nociceptive C-fibres. Acta Anaesthesiol Scand. 1990;34:335–8.

    Article  CAS  PubMed  Google Scholar 

  6. Abbott ZI, Nair KV, Allen RR, Akuthota VR. Utilization characteristics of spinal interventions. Spine J Off J North Am Spine Soc. 2012;12:35–43.

    Article  Google Scholar 

  7. Engel AJ, Kennedy DJ, Macvicar J, Bogduk N. Not all injections are the same. Anesthesiology. 2014;120:1282–3.

    Article  PubMed  Google Scholar 

  8. Kennedy DJ, Baker RM, Rathmell JP. Use of spinal injections for low back pain. JAMA. 2013;310:1736.

    Article  CAS  PubMed  Google Scholar 

  9. Ghahreman A, Bogduk N. Predictors of a favorable response to transforaminal injection of steroids in patients with lumbar radicular pain due to disc herniation. Pain Med Malden Mass. 2011;12:871–9.

    Article  Google Scholar 

  10. Spijker-Huiges A, Vermeulen K, Winters JC, van Wijhe M, van der Meer K. Costs and cost-effectiveness of epidural steroids for acute lumbosacral radicular syndrome in general practice: an economic evaluation alongside a pragmatic randomized control trial. Spine. 2014;39:2007–12.

    Article  PubMed  Google Scholar 

  11. McCormick Z, Cushman D, Casey E, Garvan C, Kennedy DJ, Plastaras C. Factors associated with pain reduction after transforaminal epidural steroid injection for lumbosacral radicular pain. Arch Phys Med Rehabil. 2014;95:2350–6.

    Article  PubMed  Google Scholar 

  12. Spijker-Huiges A, Vermeulen K, Winters JC, van Wijhe M, van der Meer K. Epidural steroids for lumbosacral radicular syndrome compared to usual care: quality of life and cost utility in general practice. Arch Phys Med Rehabil. 2015;96:381–7.

    Article  PubMed  Google Scholar 

  13. McCormick Z, Cushman D, Caldwell M, Marshall B, Ghannad L, Eng C, et al. Does electrodiagnostic confirmation of radiculopathy predict pain reduction after transforaminal epidural steroid injection? A Multicenter Study. J Nat Sci. 2015;1:140.

    Google Scholar 

  14. Maus TP, El-Yahchouchi CA, Geske JR, Carter RE, Kaufmann TJ, Wald JT, et al. Imaging determinants of clinical effectiveness of lumbar transforaminal epidural steroid injections. Pain Med Malden Mass. 2016;17:2176–84.

    Article  Google Scholar 

  15. Kennedy DJ, Schneider BJ. The challenges of research on interventions for low back pain. Ann Intern Med [Internet]. 2017 [cited 2017 Mar 23]; Available from: http://annals.org/article.aspx?doi=10.7326/M17-0556

  16. MacVicar J, King W, Landers MH, Bogduk N. The effectiveness of lumbar transforaminal injection of steroids: a comprehensive review with systematic analysis of the published data. Pain Med Malden Mass. 2013;14:14–28.

    Article  Google Scholar 

  17. Carr CM, Plastaras CT, Pingree MJ, Smuck M, Maus TP, Geske JR, et al. Immediate adverse events in interventional pain procedures: a multi-institutional study. Pain Med Malden Mass. 2016;17:2155–61.

    Article  Google Scholar 

  18. •• El-Yahchouchi CA, Plastaras CT, Maus TP, Carr CM, McCormick ZL, Geske JR, et al. Adverse event rates associated with transforaminal and interlaminar epidural steroid injections: a multi-institutional study. Pain Med Malden Mass. 2016;17:239–49 Large study involving multiple institutions has not identified any cases of permanent neurological injuries with transformational epidural steroid injections.

    Google Scholar 

  19. Plastaras C, McCormick ZL, Garvan C, Macron D, Joshi A, Chimes G, et al. Adverse events associated with fluoroscopically guided lumbosacral transforaminal epidural steroid injections. Spine J. 2015;15:2157–65.

    Article  PubMed  Google Scholar 

  20. Gilchrist RV, Slipman CW, Bhagia SM. Anatomy of the intervertebral foramen. Pain Physician. 2002;5:372–8.

    Article  PubMed  Google Scholar 

  21. Popescu A, Patel J, McCormick ZL, Maus TP, Rodes M, Walega DR, et al. Fact finders for patient safety: are gadolinium-based contrast media safe alternatives to iodinated contrast agents for the safe performance of spinal injection procedures? Pain Med Malden Mass. 2018;19:2089–90.

    Google Scholar 

  22. Smith RM, Schaefer MK, Kainer MA, Wise M, Finks J, Duwve J, et al. Fungal infections associated with contaminated methylprednisolone injections. N Engl J Med. 2013;369:1598–609.

    Article  CAS  PubMed  Google Scholar 

  23. Craig DB, Habib GG. Flaccid paraparesis following obstetrical epidural anesthesia: possible role of benzyl alcohol. Anesth Analg. 1977;56:219–21.

    CAS  PubMed  Google Scholar 

  24. Hodgson PS, Neal JM, Pollock JE, Liu SS. The neurotoxicity of drugs given intrathecally (spinal). Anesth Analg. 1999;88:797–809.

    CAS  PubMed  Google Scholar 

  25. Rathmell JP, Benzon HT, Dreyfuss P, Huntoon M, Wallace M, Baker R, et al. Safeguards to prevent neurologic complications after epidural steroid injections: consensus opinions from a multidisciplinary working group and national organizations. Anesthesiology. 2015;122:974–84.

    Article  CAS  PubMed  Google Scholar 

  26. Bogduk N, International spine intervention society, standards committee. Practice guidelines for spinal diagnostic and treatment procedures. San Francisco: International Spine Intervention Society; 2004.

  27. Houten JK, Errico TJ. Paraplegia after lumbosacral nerve root block: report of three cases. Spine J Off J North Am Spine Soc. 2002;2:70–5.

    Article  Google Scholar 

  28. Glaser SE, Falco F. Paraplegia following a thoracolumbar transforaminal epidural steroid injection. Pain Physician. 2005;8:309–14.

    Article  PubMed  Google Scholar 

  29. Kennedy DJ, Dreyfuss P, Aprill CN, Bogduk N. Paraplegia following image-guided transforaminal lumbar spine epidural steroid injection: two case reports. Pain Med Malden Mass. 2009;10:1389–94.

    Article  Google Scholar 

  30. • Lyders EM, Morris PP. A case of spinal cord infarction following lumbar transforaminal epidural steroid injection: MR imaging and angiographic findings. Am J Neuroradiol. 2009;30:1691–3 Authors presented a case report describing right L2–3 TFESI leading to spinal cord infarction. They included an MRI obtained 4 hours after the injection, demonstrating increased T2 signal in the lower thoracic cord; this was followed by a catheter-directed spinal angiography, which could not demonstrate the ostium of the right L2 segmental lumbar artery and “was presumably occluded.” This led them to postulate that the spinal cord injury was “secondary to inadvertent intra-arterial injection of thrombogenic particulate steroid.”.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Wybier M, Gaudart S, Petrover D, Houdart E, Laredo J-D. Paraplegia complicating selective steroid injections of the lumbar spine. Report of five cases and review of the literature. Eur Radiol. 2010;20:181–9.

    Article  PubMed  Google Scholar 

  32. Huntoon MA, Martin DP. Paralysis after transforaminal epidural injection and previous spinal surgery. Reg Anesth Pain Med. 2004;29:494–5.

    Article  PubMed  Google Scholar 

  33. Somayaji HS, Saifuddin A, Casey ATH, Briggs TWR. Spinal cord infarction following therapeutic computed tomography-guided left L2 nerve root injection. Spine. 2005;30:E106–8.

    Article  CAS  PubMed  Google Scholar 

  34. Gharibo C, Fakhry M, Diwan S, Kaye AD. Conus medullaris infarction after a right L4 transforaminal epidural steroid injection using dexamethasone. Pain Physician. 4.

  35. Chang Chien GC, Candido KD, Knezevic NN. Digital subtraction angiography does not reliably prevent paraplegia associated with lumbar transforaminal epidural steroid injection. Pain Physician. 2012;15:515–23.

    PubMed  Google Scholar 

  36. AbdeleRahman KT, Rakocevic G. Paraplegia following lumbosacral steroid epidural injections. J Clin Anesth. 2014;26:497–9.

    Article  PubMed  Google Scholar 

  37. Schneider B, Zheng P, Mattie R, Kennedy DJ. Safety of epidural steroid injections. Expert Opin Drug Saf. 2016;15:1031–9.

    Article  CAS  PubMed  Google Scholar 

  38. • Derby R, Lee SH, Date ES, Lee JH, Lee CH. Size and aggregation of corticosteroids used for epidural injections. Pain Med. 2008;9:227–34 Study demonstrated that corticosteroid preparations commonly used for epidural injections, including methylprednisolone, triamcinolone acetate, and betamethasone acetate all either contained particles or can aggregate into clusters larger than red blood cells.

    Article  PubMed  Google Scholar 

  39. Laemmel E, Segal N, Mirshahi M, Azzazene D, Le Marchand S, Wybier M, et al. Deleterious effects of intra-arterial administration of particulate steroids on microvascular perfusion in a mouse model. Radiology. 2016;142746.

  40. Bogduk N, Aprill C, Derby R. Lumbar discogenic pain: state-of-the-art review. Pain Med. 2013;14:813–36.

    Article  PubMed  Google Scholar 

  41. Okubadejo GO, Talcott MR, Schmidt RE, Sharma A, Patel AA, Mackey RB, et al. Perils of intravascular methylprednisolone injection into the vertebral artery. An animal study. J Bone Joint Surg Am. 2008;90:1932–8.

    Article  PubMed  Google Scholar 

  42. Murthy NS, Maus TP, Behrns CL. Intraforaminal location of the great anterior radiculomedullary artery (artery of Adamkiewicz): a retrospective review. Pain Med Malden Mass. 2010;11:1756–64.

    Article  Google Scholar 

  43. Research C for DE and. Drug Safety and Availability - FDA drug safety communication: FDA requires label changes to warn of rare but serious neurologic problems after epidural corticosteroid injections for pain [Internet]. [cited 2018 Dec 17]. Available from: https://www.fda.gov/Drugs/DrugSafety/ucm394280.htm

  44. Kennedy DJ, Plastaras C, Casey E, Visco CJ, Rittenberg JD, Conrad B, et al. Comparative effectiveness of lumbar transforaminal epidural steroid injections with particulate versus nonparticulate corticosteroids for lumbar radicular pain due to intervertebral disc herniation: a prospective, randomized, double-blind trial. Pain Med Malden Mass. 2014;15:548–55.

    Article  Google Scholar 

  45. Denis I, Claveau G, Filiatrault M, Fugère F, Fortin L. Randomized double-blind controlled trial comparing the effectiveness of lumbar transforaminal epidural injections of particulate and nonparticulate corticosteroids for lumbosacral radicular pain. Pain Med Malden Mass. 2015;16:1697–708.

    Article  Google Scholar 

  46. Park CH, Lee SH, Kim BI. Comparison of the effectiveness of lumbar transforaminal epidural injection with particulate and nonparticulate corticosteroids in lumbar radiating pain. Pain Med Malden Mass. 2010;11:1654–8.

    Article  Google Scholar 

  47. Bensler S, Sutter R, Pfirrmann C, Peterson C. Particulate versus nonparticulate corticosteroids for transforaminal nerve root blocks: comparison of outcomes in 494 patients with lumbar radiculopathy. Semin Musculoskelet Radiol. 2017;21:S1–5.

    Google Scholar 

  48. El-Yahchouchi C, Geske JR, Carter RE, Diehn FE, Wald JT, Murthy NS, et al. The noninferiority of the nonparticulate steroid dexamethasone vs the particulate steroids betamethasone and triamcinolone in lumbar transforaminal epidural steroid injections. Pain Med Malden Mass. 2013;14:1650–7.

    Article  Google Scholar 

  49. Park S-A, Ordway NR, Fayyazi AH, Fredrickson BE, Yuan HA. Comparison of Cobb technique, quantitative motion analysis, and radiostereometric analysis in measurement of segmental range of motions after lumbar total disc arthroplasty. J Spinal Disord Tech. 2009;22:602–9.

    Article  PubMed  Google Scholar 

  50. Ghobrial GM, Williams KA, Arnold P, Fehlings M, Harrop JS. Iatrogenic neurologic deficit after lumbar spine surgery: a review. Clin Neurol Neurosurg. 2015;139:76–80.

    Article  PubMed  Google Scholar 

  51. • Hwang H, Park J, Lee WK, Lee WH, Leigh J-H, Lee JJ, et al. Crystallization of local anesthetics when mixed with corticosteroid solutions. Ann Rehabil Med. 2016;40:21–7 This presented an in vitro study demonstrated that mixture of ropivicaine and dexamethasone (two agents with no particulate matter) crystallize in a pH dependent reaction.

    Article  PubMed  PubMed Central  Google Scholar 

  52. • Kordi R, White BF, Kennedy DJ. Possibility and risk of medication vial coring in interventional spine procedures. PM R. 2017;9:289–93 Describes the prevalence of coring, which can be as high as high as 97%.

    Article  PubMed  Google Scholar 

  53. Hafez MA, Al-Dars AM. Glass foreign bodies inside the knee joint following intra-articular injection. Am J Case Rep. 2012;13:238–40.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  54. Sghirlanzoni A, Marazzi R, Pareyson D, Olivieri A, Bracchi M. Epidural anaesthesia and spinal arachnoiditis. Anaesthesia. 1989;44:317–21.

    Article  CAS  PubMed  Google Scholar 

  55. Jack Adams H, Mastri AR, Charron D. Morphological effects of subarachnoid methylparaben on rabbit spinal cord. Pharmacol Res Commun. 1977;9:547–51.

    Article  Google Scholar 

  56. McLean JP, Sigler JD, Plastaras CT, Garvan CW, Rittenberg JD. The rate of detection of intravascular injection in cervical transforaminal epidural steroid injections with and without digital subtraction angiography. PM R. 2009;1:636–42.

    Article  PubMed  Google Scholar 

  57. Kennedy DJ, Mattie R, Scott Hamilton A, Conrad B, Smuck M. Detection of intravascular injection during lumbar medial branch blocks: a comparison of aspiration, live fluoroscopy, and digital subtraction technology. Pain Med Malden Mass. 2016;17:1031–6.

    Google Scholar 

  58. Nagpal AS, Chang-Chien GC, Benfield JA, Candido KD, Rana MV, Eckmann M. Digital subtraction angiography use during epidural steroid injections does not reliably distinguish artery from vein. Pain Physician. 2016;19:255–66.

    PubMed  Google Scholar 

  59. McCormick ZL, Shah VN. Objective technical considerations for appropriate digital subtraction imaging during cervical transforaminal epidural steroid injection. PM R. 2018;

  60. US EPA O. Radiation sources and doses [Internet]. US EPA. 2015 [cited 2019 Jan 9]. Available from: https://www.epa.gov/radiation/radiation-sources-and-doses

  61. Cohen SP, Bicket MC, Jamison D, Wilkinson I, Rathmell JP. Epidural steroids: a comprehensive, evidence-based review. Reg Anesth Pain Med. 2013;38:175–200.

    Article  CAS  PubMed  Google Scholar 

  62. Chang-Chien GC, Knezevic NN, McCormick Z, Chu SK, Trescot AM, Candido KD. Transforaminal versus interlaminar approaches to epidural steroid injections: a systematic review of comparative studies for lumbosacral radicular pain. Pain Physician. 2014;17:E509–24.

    PubMed  Google Scholar 

  63. Park JW, Nam HS, Cho SK, Jung HJ, Lee BJ, Park Y. Kambin’s triangle approach of lumbar transforaminal epidural injection with spinal stenosis. Ann Rehabil Med. 2011;35:833–43.

    Article  PubMed  PubMed Central  Google Scholar 

  64. Levi D, Horn S, Corcoran S. The incidence of Intradiscal, intrathecal, and intravascular flow during the performance of retrodiscal (infraneural) approach for lumbar transforaminal epidural steroid injections. Pain Med Malden Mass. 2016;17:1416–22.

    Article  Google Scholar 

  65. Osti OL, Fraser RD, Vernon-Roberts B. Discitis after discography. The role of prophylactic antibiotics. J Bone Joint Surg Br. 1990;72:271–4.

    Article  CAS  PubMed  Google Scholar 

  66. Carragee EJ, Don AS, Hurwitz EL, Cuellar JM, Carrino JA, Carrino J, et al. 2009 ISSLS prize winner: does discography cause accelerated progression of degeneration changes in the lumbar disc: a ten-year matched cohort study. Spine. 2009;34:2338–45.

    Article  PubMed  Google Scholar 

  67. Mccormick Z, Lehman V, Plastaras C, Walega RD, Huddleston MP, Moussallem C, et al. Low-pressure lumbar provocation discography according to International Association for the Study of Pain/Spine Intervention Society Standards does not cause accelerated progression of disc degeneration in symptomatic low back pain patients: a 7 year matched cohort study. Pain Med. 2018.

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Zachary L. McCormick.

Ethics declarations

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This article is part of the Topical Collection on Musculoskeletal Rehabilitation

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zheng, P., Schneider, B.J., Kennedy, D.J. et al. Safe Injectate Choice, Visualization, and Delivery for Lumbar Transforaminal Epidural Steroid Injections: Evolving Literature and Considerations. Curr Phys Med Rehabil Rep 7, 414–421 (2019). https://doi.org/10.1007/s40141-019-00244-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40141-019-00244-5

Keywords

Navigation