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Knee Osteoarthritis and Meniscal Injuries in the Runner

  • Sports Medicine Rehabilitation (B Liem and BJ Krabak, Section Editors)
  • Published:
Current Physical Medicine and Rehabilitation Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

This paper aims to review new evidence regarding the epidemiology, pathophysiology, and treatment of knee osteoarthritis and meniscal injuries in the recreational and professional running population.

Recent Findings

Though conservative measures remain the mainstay of treatment, increasing evidence shows a role for platelet-rich plasma as a conservative management option for osteoarthritis and meniscal injury, though further studies need to be performed. Cell-based therapy, such as mesenchymal stem cells, remains a controversial topic without clear evidence of their efficacy. Newer surgical options, such as collagen scaffolding and synthetic implants are under study, but surgical meniscal repair still remains the primary treatment for meniscal tears that have not responded to conservative treatment.

Summary

There is no association or causality between running low and moderate distances and knee OA. There is no causality between running and meniscal injury. There is a multitude of conservative and operative management options for both osteoarthritis and meniscal injury in runners. Platelet-rich plasma is one of the most recently studied interventions that has promising results.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Fredericson M, Misra AK. Epidemiology and aetiology of marathon running injuries. Sports Med. 2007;37(4–5):437–9. https://doi.org/10.2165/00007256-200737040-00043.

    Article  PubMed  Google Scholar 

  2. Bhattacharyya T, Gale D, Dewire P. Asymptomatic meniscal tears are as common as symptomatic ones. BMJ Br Med J Int Ed. 2003;326(7394):830.

    Google Scholar 

  3. Badlani JT, Borrero C, Golla S, Harner CD, Irrgang JJ. The effects of meniscus injury on the development of knee osteoarthritis: data from the osteoarthritis initiative. Am J Sports Med. 2013;41(6):1238–44. https://doi.org/10.1177/0363546513490276.

    Article  PubMed  Google Scholar 

  4. Papalia R, Del Buono A, Osti L, Denaro V, Maffulli N. Meniscectomy as a risk factor for knee osteoarthritis: a systematic review. Br Med Bull. 2011;99(1):89–106. https://doi.org/10.1093/bmb/ldq043.

    Article  PubMed  Google Scholar 

  5. Lawrence RC, Felson DT, Helmick CG, Arnold LM, Choi H, Deyo RA, et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States, Part II. Arthritis Rheum. 2008;58(1):26–35. https://doi.org/10.1002/art.23176.Estimates.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Zhang Y, Jordan JM. Epidemiology of osteoarthritis. Clin Geriatr Med. 2010;26(3):355–69. https://doi.org/10.1016/j.cger.2010.03.001.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Amoako AO, Pujalte GGA. Osteoarthritis in young, active, and athletic individuals. Clin Med Insights Arthritis Musculoskelet Disord. 2014;7:27–32. https://doi.org/10.4137/CMAMD.S14386.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Kujala UM, Kettunen J, Paananen H, Aalto T, Battié MC, Impivaara O, et al. Knee osteoarthritis in former runners, soccer players, weight lifters, and shooters. Arthritis Rheum. 1995;38(4):539–46. https://doi.org/10.1002/art.1780380413.

    Article  CAS  PubMed  Google Scholar 

  9. Hansen P, English M, Willick SE. Does running cause osteoarthritis in the hip or knee? PM R. 2012;4(5 SUPPL):S117–21. https://doi.org/10.1016/j.pmrj.2012.02.011.

    Article  PubMed  Google Scholar 

  10. Leech RD, Edwards KL, Batt ME. Does running protect against knee osteoarthritis? Or promote it? Assessing the current evidence. Br J Sports Med. 2015;49(21):1355–6. https://doi.org/10.1136/bjsports-2015-094749.

    Article  PubMed  Google Scholar 

  11. Marti B, Knobloch M, Tschopp A, Jucker A, Howald H. Is excessive running predictive of degenerative hip disease? Controlled study of former elite athletes. BMJ. 1989;299(6691):91–3. https://doi.org/10.1136/bmj.299.6691.91.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. • Alentorn-Geli E, Samuelsson K, Musahl V, Green CL, Bhandari M, Karlsson J. The association of recreational and competitive running with hip and knee osteoarthritis: a systematic review and meta-analysis. J Orthop Sport Phys Ther. 2017;47(6):1–36. https://doi.org/10.2519/jospt.2017.7137 Systematic review that rebuts the common misconception of a large association betweten running and knee osteoarthritis.

    Article  Google Scholar 

  13. • Timmins KA, Leech RD, Batt ME, Edwards KL. Running and knee osteoarthritis: a systematic review and meta-analysis. Am J Sports Med. 2017;45(6):1447–57. https://doi.org/10.1177/0363546516657531 Systematic review that rebuts the common misconception of a large association betweten running and knee osteoarthritis.

    Article  PubMed  Google Scholar 

  14. Williams PT. Greater weight loss from running than walking during 6.2-yr prospective follow-up Paul. Med Sci Sport Exerc. 2013;45(4):706–13. https://doi.org/10.1158/0008-5472.CAN-10-4002.BONE.

    Article  Google Scholar 

  15. Driban JB, Hootman JM, Sitler MR, Harris KP, Cattano NM. Is participation in certain sports associated with knee osteoarthritis? A Systematic Review. J Athl Train. 2017;52(6):497–506. https://doi.org/10.4085/1062-6050-50.2.08.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Willy RW, Paquette MR. The physiology and biomechanics of the master runner. Sports Med Arthrosc. 2019;27(1):15–21. https://doi.org/10.1097/JSA.0000000000000212.

    Article  PubMed  Google Scholar 

  17. Lohmander LS, Englund PM, Dahl LL, Roos EM. The long-term consequence of anterior cruciate ligament and meniscus injuries: osteoarthritis. Am J Sports Med. 2007;35(10):1756–69. https://doi.org/10.1177/0363546507307396.

    Article  PubMed  Google Scholar 

  18. Repo RU, Finlay JB. Survival of articular cartilage after controlled impact. J Bone Jt Surg - Ser A. 1977;59(8):1068–76. https://doi.org/10.2106/00004623-197759080-00012.

    Article  CAS  Google Scholar 

  19. Miller RH, Edwards WB, Brandon SCE, Morton AM, Deluzio KJ. Why don’t most runners get knee osteoarthritis? A case for per-unit-distance loads. Med Sci Sports Exerc. 2014;46(3):572–9. https://doi.org/10.1249/MSS.0000000000000135.

    Article  PubMed  Google Scholar 

  20. National Collaborating Centre for Chronic Conditions N-C. Osteoarthritis: national clinical guideline for care and management in adults, vol. 10. London: Royal College of Physicians; 2008. 1–386 p. p. 346–58. https://doi.org/10.1057/eps.2010.51.

    Book  Google Scholar 

  21. Egloff C, Hügle T, Valderrabano V. Biomechanics and pathomechanisms of osteoarthritis. Swiss Med Wkly. 2012;142(JULY):1–14. https://doi.org/10.4414/smw.2012.13583.

    Article  Google Scholar 

  22. Tanamas S, Hanna FS, Cicuttini FM, Wluka AE, Berry P, Urquhart DM. Does knee malalignment increase the risk of development and progression of knee osteoarthritis? A systematic review. Arthritis Care Res. 2009;61(4):459–67. https://doi.org/10.1002/art.24336.

    Article  Google Scholar 

  23. Yang NH, Nayeb-Hashemi H, Canavan PK, Vaziri A. Effect of frontal plane tibiofemoral angle on the stress and strain at the knee cartilage during the stance phase of gait. J Orthop Res. 2010;28(12):1539–47. https://doi.org/10.1002/jor.21174.

    Article  PubMed  Google Scholar 

  24. •• Zhang W, Doherty M, Peat G, Bierma-Zeinstra MA, Arden NK, Bresnihan B, et al. EULAR evidence-based recommendations for the diagnosis of knee osteoarthritis. Ann Rheum Dis. 2010;69(3):483–9. https://doi.org/10.1136/ard.2009.113100 Guidelines for knee osteoarthritis developed by a multidisciplinary group representing 12 European countries.

    Article  CAS  PubMed  Google Scholar 

  25. Hawker GA, Stewart L, French MR, Cibere J, Jordan JM, March L, et al. Understanding the pain experience in hip and knee osteoarthritis - an OARSI/OMERACT initiative. Osteoarthr Cartil. 2008;16(4):415–22. https://doi.org/10.1016/j.joca.2007.12.017.

    Article  CAS  PubMed  Google Scholar 

  26. Kohn MD, Sassoon AA, Fernando ND. Classifications in brief: Kellgren-Lawrence classification of osteoarthritis. Clin Orthop Relat Res. 2016;474(8):1886–93. https://doi.org/10.1007/s11999-016-4732-4.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Nguyen U-SDT, Zhang Y, Zhu Y, Niu J, Zhan B, Aliabadi P, et al. Increasing prevalence of knee pain and symptomatic knee osteoarthritis. Ann Intern Med. 2012;155(11):725–32. https://doi.org/10.1059/0003-4819-155-11-201112060-00004.Increasing.

    Article  Google Scholar 

  28. Hochberg MC, Altman RD, April KT, Benkhalti M, Guyatt G, McGowan J, et al. American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. Arthritis Care Res. 2012;64(4):465–74. https://doi.org/10.1002/acr.21596.

    Article  CAS  Google Scholar 

  29. Herrlin S, Hållander M, Wange P, Weidenhielm L, Werner S. Arthroscopic or conservative treatment of degenerative medial meniscal tears: a prospective randomised trial. Knee Surg Sport Traumatol Arthrosc. 2007;15(4):393–401. https://doi.org/10.1007/s00167-006-0243-2.

    Article  Google Scholar 

  30. Fransen M, McConnell S, Harmer AR, Van der Esch M, Simic M, Bennell KL. Exercise for osteoarthritis of the knee. Cochrane Database Syst Rev. 2015. https://doi.org/10.1016/0378-5955(92)90022-F.

  31. Kaufman KR, Hughes C, Morrey BF, Morrey M, An KN. Gait characteristics of patients with knee osteoarthritis. J Biomech. 2001;34(7):907–15. https://doi.org/10.1016/S0021-9290(01)00036-7.

    Article  CAS  PubMed  Google Scholar 

  32. Bartels E, Juhl C, Christensen R, Hagen K, Danneskiold-Samøe B, Dagfinrud H, et al. Aquatic exercise for the treatment of knee and hip osteoarthritis ( review ). Cochrane Libr. 2016;3:1–67. https://doi.org/10.1002/14651858.CD005523.pub3.www.cochranelibrary.com.

    Article  Google Scholar 

  33. Nigg BM. Comment on “the influence of running velocity and midsole hardness on external impact forces in heel-toe-running”. J Biomech. 1989;22(8–9):963–5. https://doi.org/10.1016/0021-9290(89)90081-X.

    Article  Google Scholar 

  34. Wakeling JM, Pascual SA, Nigg BM. Altering muscle activity in the lower extremities by running with different shoes. / alteration de l ’ activite musculaire dans les extremites des membres inferieurs, en courant avec differentes chaussures. Med Sci Sport Exerc. 2002;34(9):1529–32. https://doi.org/10.1249/01.MSS.0000027714.70099.08.

    Article  Google Scholar 

  35. Ly QH, Alaoui A, Erlicher S, Baly L. Towards a footwear design tool: influence of shoe midsole properties and ground stiffness on the impact force during running. J Biomech. 2010;43(2):310–7. https://doi.org/10.1016/j.jbiomech.2009.08.029.

    Article  PubMed  Google Scholar 

  36. Huleatt JB, Campbell KJ, LaPrade RF. Nonoperative treatment approach to knee osteoarthritis in the master athlete. Sports Health. 2014;6(1):56–62. https://doi.org/10.1177/1941738113501460.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Nelson AE, Allen KD, Golightly YM, Goode AP, Jordan JM. A systematic review of recommendations and guidelines for the management of osteoarthritis: the chronic osteoarthritis management initiative of the U.S. bone and joint initiative. Semin Arthritis Rheum. 2014;43(6):701–12. https://doi.org/10.1016/j.semarthrit.2013.11.012.

    Article  PubMed  Google Scholar 

  38. Pincus T, Koch GG, Sokka T, Lefkowith J, Wolfe F, Jordan JM, et al. A randomized, double-blind, crossover clinical trial of diclofenac plus misoprostol versus acetaminophen in patients with osteoarthritis of the hip or knee. Arthritis Rheum. 2001;44(7):1587–98. https://doi.org/10.1002/1529-0131(200107)44:7<1587::AID-ART282>3.0.CO;2-X.

    Article  CAS  PubMed  Google Scholar 

  39. Felson DT. The verdict favors nonsteroidal antiinflammatory drugs for treatment of osteoarthritis and a Plea for more evidence on other treatments. Arthritis Rheum. 2001;44(7):1477–80. https://doi.org/10.1002/art.34585.

    Article  CAS  PubMed  Google Scholar 

  40. Felson DT. Clinical practice. Osteoarthritis of the knee. N Engl J Med. 2006;354(8):841–8. https://doi.org/10.1056/NEJMcp051726.

    Article  CAS  PubMed  Google Scholar 

  41. Frampton JE, Keating GM. Celecoxib - a review of its use in the management of arthritis and acute pain. Drugs. 2007;67(16):2433–74.

    Article  CAS  Google Scholar 

  42. Bellamy N, Campbell J, Robinson V, Gee T, Bourne R, Wells G. Viscosupplementation for the treatment of osteoarthritis of the knee. [Systematic Review] Cochrane Musculoskeletal Group. Cochrane Database Syst Rev. 2005;2(2):244.

    Google Scholar 

  43. McAlindon TE, La Valley MP, Gulin JP, Felson DT. Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis. J Am Med Assoc. 2000;283(11):1469–75. https://doi.org/10.1001/jama.283.11.1469.

    Article  CAS  Google Scholar 

  44. Clegg DO, Reda DJ, Harris CL, Klein MA, O’Dell JR, Hooper MM, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med. 2006;354(8):795–808.

    Article  CAS  Google Scholar 

  45. Cushman DM, Bruno B, Christiansen J, Schultz A, McCormick ZL. Efficacy of injected corticosteroid type, dose, and volume for pain in large joints: a narrative review. PM R. 2018;10(7):748–57. https://doi.org/10.1016/j.pmrj.2018.01.002.

    Article  PubMed  Google Scholar 

  46. Zeng C, Lane NE, Hunter DJ, Wei J, Choi HK, McAlindon TE, et al. Intra-articular corticosteroids and the risk of knee osteoarthritis progression: results from the osteoarthritis initiative. Osteoarthr Cartil. 2019;27:855–62. https://doi.org/10.1016/j.joca.2019.01.007.

    Article  CAS  PubMed  Google Scholar 

  47. Dragoo JL, Danial CM, Braun HJ, Pouliot MA, Kim HJ. The chondrotoxicity of single-dose corticosteroids. Knee Surg Sports Traumatol Arthrosc. 2012 [cited 2016 Dec 23];20(9):1809–14. https://doi.org/10.1007/s00167-011-1820-6.

    Article  PubMed  Google Scholar 

  48. McAlindon TE, Bannuru RR, Sullivan MC, Arden NK, Berenbaum F, Bierma-Zeinstra SM, et al. OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthr Cartil. 2014;22(3):363–88. https://doi.org/10.1016/j.joca.2014.01.003.

    Article  CAS  PubMed  Google Scholar 

  49. Brown GA. AAOS clinical practice guideline: treatment of osteoarthritis of the knee: evidence-based guideline, 2nd edition. J Am Acad Orthop Surg. 2013;21(9):577–9. https://doi.org/10.5435/JAAOS-21-09-577.

    Article  PubMed  Google Scholar 

  50. Busse P, Vater C, Stiehler M, Nowotny J, Kasten P, Bretschneider H, et al. Cytotoxicity of drugs injected into joints in orthopaedics. Bone Joint Res. 2019;8(2):41–8. https://doi.org/10.1302/2046-3758.82.BJR-2018-0099.R1.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Meheux CJ, McCulloch PC, Lintner DM, Varner KE, Harris JD. Efficacy of intra-articular platelet-rich plasma injections in knee osteoarthritis: a systematic review. Arthroscopy. 2016;32(3):495–505. https://doi.org/10.1016/j.arthro.2015.08.005.

    Article  PubMed  Google Scholar 

  52. O’Connell B, Wragg NM, Wilson SL. The use of PRP injections in the management of knee osteoarthritis. Cell Tissue Res. 2019;(Table 1). https://doi.org/10.1007/s00441-019-02996-x.

  53. Braun HJ, Kim HJ, Chu CR, Dragoo JL. The effect of platelet-rich plasma formulations and blood products on human synoviocytes. Am J Sports Med. 2014;42(5):1204–10. https://doi.org/10.1177/0363546514525593.

    Article  PubMed  PubMed Central  Google Scholar 

  54. Riboh JC, Saltzman BM, Yanke AB, Fortier L, Cole BJ. Effect of leukocyte concentration on the efficacy of platelet-rich plasma in the treatment of knee osteoarthritis. Am J Sports Med. 2016;44(3):792–800. https://doi.org/10.1177/0363546515580787.

    Article  PubMed  Google Scholar 

  55. Daley EL, Bajaj S, Bisson LJ, Cole BJ. Improving injection accuracy of the elbow, knee, and shoulder: does injection site and imaging make a difference? A systematic review. Am J Sport Med. 2011/01/25. 2011;39(3):656–62. https://doi.org/10.1177/0363546510390610.

    Article  Google Scholar 

  56. Lana JF, Macedo A, ILG I, Huber SC, Santos GS, Santana MHA. Leukocyte-rich PRP for knee osteoarthritis: Current concepts. J Clin Orthop Trauma. 2019;xxxx:1–4. https://doi.org/10.1016/j.jcot.2019.01.011.

    Article  Google Scholar 

  57. Pas HI, Winters M, Haisma HJ, Koenis MJ, Tol JL, Moen MH. Stem cell injections in knee osteoarthritis: a systematic review of the literature. Br J Sports Med. 2017;51(15):1125–33. https://doi.org/10.1136/bjsports-2016-096793.

    Article  PubMed  Google Scholar 

  58. Feeley BT, Gallo RA, Sherman S, Williams RJ. Management of osteoarthritis of the knee in the active patient. J Am Acad Orthop Surg. 2010;18(7):406–16. https://doi.org/10.5435/00124635-201007000-00003.

    Article  PubMed  Google Scholar 

  59. Swanson EA, Schmalzried TP, Dorey FJ. Activity recommendations after total hip and knee arthroplasty. J Arthroplasty. 2009;24(6):120–6. https://doi.org/10.1016/j.arth.2009.05.014.

    Article  PubMed  Google Scholar 

  60. Makris EA, Hadidi P, Athanasiou KA. The knee meniscus: structure-function, pathophysiology, current repair techniques, and prospects for regeneration. Biomaterials. 2011;32(30):7411–31. https://doi.org/10.1016/j.biomaterials.2011.06.037.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  61. Fox AJS, Wanivenhaus F, Burge AJ, Warren RF, Rodeo SA. The human meniscus: a review of anatomy, function, injury, and advances in treatment. Clin Anat. 2015;28(2):269–87. https://doi.org/10.1002/ca.22456.

    Article  PubMed  Google Scholar 

  62. • Taunton JE, Ryan MB, Clement DB, McKenzie DC, Lloyd-Smith DR, Zumbo BD. A retrospective case-control analysis of 2002 running injuries. Br J Sport Med. 2002/03/28. 2002 [cited 2018 Sep 2];36(2):95–101. Study examining a large amount of running-related injuries. This is a highly-cited article used in many epidemiologic studies.

  63. Baker P, Coggon D, Reading I, Barrett D, McLaren M, Cooper C. Sports injury, occupational physical activity, joint laxity, and meniscal damage. J Rheumatol. 2002;29(3):557–63. https://doi.org/10.1177/0363546506287939.

    Article  PubMed  Google Scholar 

  64. Baker P, Reading I, Cooper C, Coggon D. Knee disorders in the general population and their relation to occupation. Occup Environ Med. 2003;60(10):794–7.

    Article  CAS  Google Scholar 

  65. Snoeker BAM, Bakker EWP, Kegel CAT, Lucas C. Risk factors for meniscal tears: a systematic review including meta-analysis. J Orthop Sport Phys Ther. 2013;43(6):352–67. https://doi.org/10.2519/jospt.2013.4295.

    Article  Google Scholar 

  66. Hoessly ML, Wildi LM. Magnetic resonance imaging findings in the knee before and after long-distance running - documentation of irreversible structural damage? A systematic review. Am J Sports Med. 2017;45(5):1206–17. https://doi.org/10.1177/0363546516656180.

    Article  PubMed  Google Scholar 

  67. Boocock M, McNair P, Cicuttini F, Stuart A, Sinclair T. The short-term effects of running on the deformation of knee articular cartilage and its relationship to biomechanical loads at the knee. Osteoarthr Cartil. 2009;17(7):869–76. https://doi.org/10.1016/j.joca.2008.12.010.

    Article  Google Scholar 

  68. Kessler MA, Glaser C, Tittel S, Reiser M, Imhoff AB. Volume changes in the menisci and articular cartilage of runners: an in vivo investigation based on 3-D magnetic resonance imaging. Am J Sports Med. 2006;34(5):832–6. https://doi.org/10.1177/0363546505282622.

    Article  PubMed  Google Scholar 

  69. Mosher TJ, Smith HE, Collins C, Liu Y, Hancy J, Dardzinski BJ, et al. Change in knee cartilage T2 at MR imaging after running: a feasibility study. Radiology. 2005;234(1):245–9. https://doi.org/10.1148/radiol.2341040041.

    Article  PubMed  Google Scholar 

  70. Shellock FG, Mink JH. Knees of trained long-distance runners: MR imaging before and after competition. Radiology. 1991;179(3):635–7. https://doi.org/10.1148/radiology.179.3.2027965.

    Article  CAS  PubMed  Google Scholar 

  71. Greis PE, Bardana DD, Holmstrom MC, Burks RT. Meniscal injury: I. Basic science and evaluation. J Am Acad Orthop Surg. 2002;10(3):168–76. https://doi.org/10.5435/00124635-200205000-00003.

    Article  PubMed  Google Scholar 

  72. Howell R. Degenerative meniscus: pathogenesis, diagnosis, and treatment options. World J Orthop. 2014;5(5):597–602. https://doi.org/10.5312/wjo.v5.i5.597.

    Article  PubMed  PubMed Central  Google Scholar 

  73. Englund M, Roos EM, Roos HP, Lohmander LS. Patient-relevant outcomes fourteen years after meniscectomy: influence of type of meniscal tear and size of resection. Rheumatology (Oxford). 2001;40(6):631–9.

    Article  CAS  Google Scholar 

  74. Wang D, Cai X, Liu Y, Wang Z, Gao L. [Meniscus injury in osteoarthritis of knee joints: under arthroscopy]. Zhonghua Yi Xue Za Zhi. 2005 Sep;85(34):2425–7.

    PubMed  Google Scholar 

  75. Arnoczky SP, Warren RF. Microvasculature of the human meniscus. Am Ortho Sport Med. 1982;10(2):90–5.

    Article  CAS  Google Scholar 

  76. Eckstein F, Tieschky M, Faber S, Englmeier KH, Reiser M. Functional analysis of articular cartilage deformation, recovery, and fluid flow following dynamic exercise in vivo. Anat Embryol (Berl). 1999;200(4):419–24. https://doi.org/10.1007/s004290050291.

    Article  CAS  Google Scholar 

  77. Kessler MA, Glaser C, Tittel S, Reiser M, Imhoff AB. Recovery of the menisci and articular cartilage of runners after cessation of exercise: additional aspects of in vivo investigation based on 3-dimensional magnetic resonance imaging. Am J Sports Med. 2008;36(5):966–70. https://doi.org/10.1177/0363546507313093.

    Article  PubMed  Google Scholar 

  78. Hinterwimmer S, Feucht MJ, Steinbrech C, Graichen H, von Eisenhart-Rothe R. The effect of a six-month training program followed by a marathon run on knee joint cartilage volume and thickness in marathon beginners. Knee Surg Sport Traumatol Arthrosc. 2014;22(6):1353–9. https://doi.org/10.1007/s00167-013-2686-6.

    Article  Google Scholar 

  79. Krampla W, Mayrhofer R, Malcher J, Kristen KH, Urban M, Hruby W. MR imaging of the knee in marathon runners before and after competition. Skelet Radiol. 2001/04/20. 2001;30(2):72–6.

    Article  CAS  Google Scholar 

  80. Luke AC, Stehling C, Stahl R, Li X, Kay T, Takamoto S, et al. High-field magnetic resonance imaging assessment of articular cartilage before and after marathon running: does long-distance running lead to cartilage damage? Am J Sports Med. 2010;38(11):2273–80. https://doi.org/10.1177/0363546510372799.

    Article  PubMed  Google Scholar 

  81. Stehling C, Luke A, Stahl R, Baum T, Joseph G, Pan J, et al. Meniscal T1rho and T2 measured with 3.0T MRI increases directly after running a marathon. Skelet Radiol. 2011;40(6):725–35. https://doi.org/10.1007/s00256-010-1058-2.

    Article  Google Scholar 

  82. Smith BW, Green GA. Acute knee injuries: part I. History and physical examination. Am Fam Physician. 1995;51(3):615–21.

    CAS  PubMed  Google Scholar 

  83. Scholten RJ, Devillé WL, Opstelten W, Bijl D, van der Plas CG, Bouter LM. The accuracy of physical diagnostic tests for assessing meniscal lesions of the knee: a meta-analysis. J Fam Pract. 2001;50(11):938–44.

    CAS  PubMed  Google Scholar 

  84. Strayer RJ, Lang ES. Does this patient have a torn meniscus or ligament of the knee? Ann Emerg Med. 2006;47(5):499–501. https://doi.org/10.1016/j.annemergmed.2006.02.004.

    Article  PubMed  Google Scholar 

  85. Karachalios T. Diagnostic accuracy of a new clinical test (the Thessaly test) for early detection of meniscal tears. J Bone Jt Surg. 2005;87(5):955–62.

    Article  Google Scholar 

  86. Cook JL, Cook CR, Stannard JP, Vaughn G, Wilson N, Roller BL, et al. MRI versus ultrasonography to assess meniscal abnormalities in acute knees. J Knee Surg. 2014;27(4):319–24. https://doi.org/10.1055/s-0034-1367731.

    Article  PubMed  Google Scholar 

  87. Zanetti M, Pfirrmann CWA, Schmid MR, Romero J, Seifert B, Hodler J. Patients with suspected meniscal tears: prevalence of abnormalities seen on MRI of 100 symptomatic and 100 contralateral asymptomatic knees. AJR Am J Roentgenol. 2003;181(3):635–41. https://doi.org/10.2214/ajr.181.3.1810635.

    Article  PubMed  Google Scholar 

  88. •• Khan M, Evaniew N, Bedi A, Ayeni OR, Bhandari M. Arthroscopy surgery for degenerative tears of the meniscus: a systematic review and meta-analysis. Can Med Assoc Licens. 2014;186(14):1057–64. https://doi.org/10.1503/cmaj.140433/-/DC1 Extensive review of the results of arthroscopic surgery for degenerative meniscus tears.

    Article  Google Scholar 

  89. • Katz JN, Brophy RH, Chaisson CE, de Chaves L, Cole BJ, Dahm DL, et al. Surgery versus physical therapy for a meniscal tear and osteoarthritis. N Engl J Med. 2013;368(18):1675–84. https://doi.org/10.1056/NEJMoa1301408 Randomized trial comparing operative versus non-operative treatment of degenerative meniscus tears. Waiting on surgery was a very valid option.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  90. Scordino LE, DeBerardino TM. Biologic enhancement of meniscus repair. Clin Sports Med. 2012;31(1):91–100. https://doi.org/10.1016/j.csm.2011.09.001.

    Article  PubMed  Google Scholar 

  91. Noyes FR, Barber-Westin SD. Repair of complex and avascular meniscal tears and meniscal transplantation. J Bone Jt Surg. 2010;92(4):1012–29. https://doi.org/10.2106/JBJS.H.00034.

    Article  Google Scholar 

  92. Yu H, Adesida AB, Jomha NM. Meniscus repair using mesenchymal stem cells - a comprehensive review. Stem Cell Res Ther. 2015;6:86. https://doi.org/10.1186/s13287-015-0077-2.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  93. Vangsness CT, Farr J, Boyd J, Dellaero DT, Mills CR, LeRoux-Williams M. Adult human mesenchymal stem cells delivered via intra-articular injection to the knee following partial medial meniscectomy: a randomized, double-blind, controlled study. J Bone Joint Surg Am. 2014;96(2):90–8. https://doi.org/10.2106/JBJS.M.00058.

    Article  PubMed  Google Scholar 

  94. Fairbank TJ. Knee joint changes after meniscectomy. J Bone Joint Surg Br. 1948;30B(4):664–70.

    Article  CAS  Google Scholar 

  95. Laible C, Stein DA, Kiridly DN. Meniscal Repair. J Am Acad Orthop. 2013;21:204–13.

    Article  Google Scholar 

  96. Taylor SA, Rodeo SA. Augmentation techniques for isolated meniscal tears. Curr Rev Musculoskelet Med. 2013;6(2):95–101. https://doi.org/10.1007/s12178-013-9165-z.

    Article  PubMed  PubMed Central  Google Scholar 

  97. Willy RW, Bigelow MA, Kolesar A, Willson JD, Thomas JS. Knee contact forces and lower extremity support moments during running in young individuals post-partial meniscectomy. Knee Surg Sport Traumatol Arthrosc. 2017;25(1):115–22. https://doi.org/10.1007/s00167-016-4143-9.

    Article  CAS  Google Scholar 

  98. Baumgarten B. To run or not to run: a post-meniscectomy qualitative risk analysis model for osteoarthritis when considering a return to recreational running. J Man Manip Ther. 2007;15(1):1–15. https://doi.org/10.1179/jmt.2007.15.1.1e.

    Article  Google Scholar 

  99. Henning CE, Lynch M A, Yearout KM, Vequist SW, Stallbaumer RJ, Decker KA. Arthroscopic meniscal repair using an exogenous fibrin clot. Clin Orthop Relat Res. 1990;64–72.

  100. van Trommel MF, Simonian PT, Potter HG, Wickiewicz TL. Arthroscopic meniscal repair with fibrin clot of complete. Arthrosc J Arthrosc Relat Surg. 1998;14(4):360–5.

    Article  Google Scholar 

  101. Hennerbichler A, Moutos FT, Hennerbichler D, Weinberg JB, Guilak F. Interleukin-1 and tumor necrosis factor alpha inhibit repair of the porcine meniscus in vitro. Osteoarthr Cartil. 2007;15(9):1053–60. https://doi.org/10.1016/j.joca.2007.03.003.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  102. Vrancken ACT, Buma P, Van Tienen TG. Synthetic meniscus replacement: a review. Int Orthop. 2013;37(2):291–9. https://doi.org/10.1007/s00264-012-1682-7.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Division of Emergency Medicine, Department of Surgery, Salt Lake City, UT, USA

    William Denq

  2. University of Utah Orthopaedic Center, 590 Wakara Way, Salt Lake City, UT, 84108, USA

    William Denq & Daniel M. Cushman

  3. Division of Physical Medicine and Rehabilitation, University of Utah, Salt Lake City, UT, USA

    Daniel M. Cushman

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Denq, W., Cushman, D.M. Knee Osteoarthritis and Meniscal Injuries in the Runner. Curr Phys Med Rehabil Rep 7, 237–245 (2019). https://doi.org/10.1007/s40141-019-00235-6

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