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Chronic tendon injuries are a common cause of pain and of restriction of sports or daily life. Even though a number of published studies have focused on tendon injuries, healing and treatment, the pathogenesis still remains enigmatic. The pathogenesis of chronic tendon injuries is considered multifactorial, however the precise role of each predisposing factor remains incompletely understood. The association between tendinopathy and pain should also be clarified, as the presence of tendinopathic lesions does not always lead to symptoms, but they are the necessary pre-existing conditions for spontaneous tendon ruptures. In this article, the histological features, the pathogenetic theories of tendinopathy, and the possible sources of pain are reviewed.
KeywordsTendinopathy Tendon injury Tendon healing Ruptures Musculoskeletal rehabilitation Physical medicine and rehabilitation Review
Papers of particular interest, published recently, have been highlighted as: •• Of major importance
- 3.American Academy of Orthpoedic Surgeons. Rotator cuff tears. OrthoInfo 2011. http://orthoinfo.aaos.org/topic.cfm?topic=A00064.
- 10.Battery L, Maffulli N. Inflammation in Overuse Tendon Injuries. Sports Med Arthrosc Rev. 2011;19:13–217.Google Scholar
- 11.•• Hast MW, Abboud JA, Soslowsky LJ. Exploring the role of hypercolesterolemia in tendon health and repair. Muscles Ligaments Tendons J. 2014;4:275–9. This article is of major importance because showes the influence of hypercolesterolemia on tendon omeostasis and tendon healing. Google Scholar
- 12.•• Snedeker JG, Gautieri A. The role of collagen crosslinks in aging and diabetes: the good, the bad and the ugly. Muscles Ligaments Tendons J. 2014;4:303–8. Many patients who suffered a tendinopathy or tendon rupture, like Achilles tendinopathy, Achilles tendon rupture or a rotator cuff tear are also diabetic. This article is of major importance because shows the influence of hypercolesterolemia on mechanical properties of tendons and it may predispose tendons to injury. Google Scholar
- 19.Hansen M, Couppe C, Hansen CS, et al. Impact of oral contraceptive use and menstrual phases on patellar tendon morphology, biochemical composition, and biomechanical properties in female athletes. J Appl Physiol. 1985;2013(114):998–1008.Google Scholar
- 25.•• Oliva F, Osti L, Padulo J, Maffulli N. Epidemiology of the rotator cuff tears: a new incidence related to thyroid disease. Muscles Ligaments Tendons J. 2014;4:309–14. This article is of importance because it reported an higher incidence of rotator cuff tears in patients with hypothyroidism, showing a significant correlation between thyroid disease and tendon injury. Google Scholar
- 26.•• Oliva F, Berardi AC, Misiti S, Verza Felzacappa C, Iacone A, Maffulli N. Thyroid hormones enhance growth and counteract apoptosis in human tenocytes isolated from rotator cuff tendons. Cell Death Dis. 2013;4:e705. It is and in vitro study which demonstrate the presence of THs receptors both in healthy and pathological tendons. It is of major importance because it first showed the influence of TH on tendon homeostasis and tenocytes proliferation. Google Scholar
- 29.Magra M, Maffulli N Genetics: Does it play a role in tendinopathy? Clin J Sport Med 2007.Google Scholar