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Chronic Inflammation After TBI and Associated Behavioral Sequelae

  • John P. Skendelas
  • Megan Muccigrosso
  • Daniel S. Eiferman
  • Jonathan P. Godbout
Traumatic Brain Injury Rehabilitation (AK Wagner, Section Editor)
  • 125 Downloads
Part of the following topical collections:
  1. Traumatic Brain Injury Rehabilitation

Abstract

Traumatic brain injury (TBI) is associated with peripheral and central inflammatory processes that contribute to injury pathology and functional recovery. Unfortunately, there are no effective therapies for limiting either the immediate or long-term neurological consequences of TBI. The purpose of this review is to briefly summarize the relevant TBI pathophysiology and current clinical strategies to reduce inflammation, and to discuss the role of ongoing inflammatory processes that may contribute to long-term neuropsychiatric complications associated with TBI.

Keywords

Traumatic brain injury Chronic neuroinflammation Depression Neurodegenerative disease 

Notes

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science + Business Media New York 2015

Authors and Affiliations

  1. 1.College of MedicineThe Ohio State UniversityColumbusUSA
  2. 2.Department of NeuroscienceThe Ohio State UniversityColumbusUSA
  3. 3.Department of SurgeryThe Ohio State UniversityColumbusUSA
  4. 4.Center for Brain and Spinal Cord RepairThe Ohio State UniversityColumbusUSA
  5. 5.Institute for Behavioral Medicine ResearchThe Ohio State UniversityColumbusUSA

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