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A Practical Approach to Assessment and Management of Patients at Risk for Non-medical Opioid Use: a Focus on the Patient with Cancer-Related Pain

  • Opioid Use in an Opioid Epidemic (S Dalal, Section Editor)
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Abstract

Purpose of Review

Over the past decade, the perception of prescription opioids changed dramatically. Once considered a savior from all types of pain, with few side effects and no celling dose, opioids are now restricted by many states, health insurance companies, and pharmacies. This narrative review aims to synthesize the latest evidence for managing oncology patients at risk for non-medical opioid use (NMOU).

Recent Findings

Opioids are effective medications for reducing severe cancer pain, despite their side effects. Screening tools identify high-risk patients, and a nomogram is available, using routine clinical data. Prescription monitoring plans have some evidence for improving selected outcomes; however, the role of UDT remains unclear. Harm reduction measures include de-prescribing of benzodiazepines, opioid rotation, and scheduled rather than PRN dosing.

Summary

About one in five cancer patients are at risk for NMOU. There are effective strategies for identifying high-risk patients, reducing harm, and providing interdisciplinary psychosocial support.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Hahn KL. Strategies to prevent opioid misuse, abuse, and diversion that may also reduce the associated costs. Am Health Drug Benefits. 2011;4(2):107–14.

    PubMed  PubMed Central  Google Scholar 

  2. Hedegaard H, Miniño AM, Warner M. Drug overdose deaths in the United States, 1999-2018. NCHS Data Brief. 2020;356:1–8.

    Google Scholar 

  3. •• Wiffen PJ, Wee B, Derry S, Bell RF, Moore RA. Opioids for cancer pain - an overview of Cochrane reviews. Cochrane Database Syst Rev. 2017;7(7):CD012592. https://doi.org/10.1002/14651858.CD012592.pub2Few randomized controlled trials are available, however the evidence for opioids reducing severe cancer pain is compelling.

    Article  PubMed  Google Scholar 

  4. Yennurajalingam S, Kang JH, Hui D, Kang DH, Kim SH, Bruera E. Clinical response to an outpatient palliative care consultation in patients with advanced cancer and cancer pain. J Pain Symptom Manage. 2012 Sep;44(3):340–50. https://doi.org/10.1016/j.jpainsymman.2011.09.014.

    Article  PubMed  Google Scholar 

  5. Vargovich AM, Schumann ME, Xiang J, Ginsberg AD, Palmer BA, Sperry JA. Difficult conversations: training medical students to assess, educate, and treat the patient with chronic pain. Acad Psychiatry. 2019 Oct;43(5):494–8. https://doi.org/10.1007/s40596-019-01072-4.

    Article  PubMed  Google Scholar 

  6. Arthur J, Edwards T, Lu Z, Hui D, Fellman B, Bruera E. Health care provider attitudes, beliefs, and perceived confidence in managing patients with cancer pain and nonmedical opioid use. J Pain Symptom Manage. 2020;S0885-3924(20):30584-4. https://doi.org/10.1016/j.jpainsymman.2020.06.040 Epub ahead of print.

    Article  Google Scholar 

  7. Voon P, Kerr T. “Nonmedical” prescription opioid use in North America: a call for priority action. Subst Abuse Treat Prev Policy. 2013;8:39. https://doi.org/10.1186/1747-597X-8-39.

    Article  PubMed  PubMed Central  Google Scholar 

  8. •• Moride Y, Lemieux-Uresandi D, Castillon G, de Moura CS, Pilote L, Faure M, et al. A systematic review of interventions and programs targeting appropriate prescribing of opioids. Pain Physician. 2019;22(3):229–40 Evidence is lacking for effective interventions.

    PubMed  Google Scholar 

  9. Andersson V, Bergman S, Henoch I, Simonsson H, Ahlberg K. Benefits of using the Brief Pain Inventory in patients with cancer pain: an intervention study conducted in Swedish hospitals. Support Care Cancer. 2020;28(8):3721–9. https://doi.org/10.1007/s00520-019-05200-6.

    Article  PubMed  Google Scholar 

  10. • Klimas J, Gorfinkel L, Fairbairn N, Amato L, Ahamad K, Nolan S, et al. Strategies to identify patient risks of prescription opioid addiction when initiating opioids for pain: a systematic review. JAMA Netw Open. 2019;2(5):e193365. https://doi.org/10.1001/jamanetworkopen.2019.3365Risk factors obtained from readily available clinical information.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Yennurajalingam S, Edwards T, Arthur JA, Lu Z, Najera J, Nguyen K, et al. Predicting the risk for aberrant opioid use behavior in patients receiving outpatient supportive care consultation at a comprehensive cancer center. Cancer. 2018;124(19):3942–9. https://doi.org/10.1002/cncr.31670.

    Article  CAS  PubMed  Google Scholar 

  12. Carmichael AN, Morgan L, Del Fabbro E. Identifying and assessing the risk of opioid abuse in patients with cancer: an integrative review. Subst Abuse Rehabil. 2016;7:71–9. https://doi.org/10.2147/SAR.S85409.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Greiner RS, Boselli D, Patel JN, Salib M, Edelen C, Walsh D. Opioid risk screening in an oncology palliative medicine clinic. JCO Oncol Pract. 2020;30:OP2000043. https://doi.org/10.1200/OP.20.00043 Epub ahead of print.

    Article  Google Scholar 

  14. Koyyalagunta D, Bruera E, Engle MP, Driver L, Dong W, Demaree C, et al. Compliance with opioid therapy: distinguishing clinical characteristics and demographics among patients with cancer pain. Pain Med. 2018;19(7):1469–77. https://doi.org/10.1093/pm/pnx178.

    Article  PubMed  Google Scholar 

  15. •• Yennurajalingam S, Edwards T, Arthur J, Lu Z, Erdogan E, Malik JS, et al. The development of a nomogram to determine the frequency of elevated risk for non-medical opioid use in cancer patients. Palliat Support Care. 2020:1–8. https://doi.org/10.1017/S1478951520000322Accessible online, requiring clinical data and two brief questionnaires.

  16. Rauenzahn S, Sima A, Cassel B, Noreika D, Gomez TH, Ryan L, et al. Urine drug screen findings among ambulatory oncology patients in a supportive care clinic. Support Care Cancer. 2017 Jun;25(6):1859–64. https://doi.org/10.1007/s00520-017-3575-1.

    Article  PubMed  Google Scholar 

  17. • Arthur JA. Urine drug testing in cancer pain management. Oncologist. 2020;25(2):99–104. https://doi.org/10.1634/theoncologist.2019-0525A comprehensive review, including interpretation of UDT.

    Article  PubMed  Google Scholar 

  18. Liang D, Guo H, Shi Y. Mandatory use of prescription drug monitoring program and benzodiazepine prescribing among U.S. Medicaid enrollees. Subst Abus. 2019:1–8. https://doi.org/10.1080/08897077.2019.1686722 Epub ahead of print. PMCID: PMC7202951.

  19. Rhodes E, Wilson M, Robinson A, Hayden JA, Asbridge M. The effectiveness of prescription drug monitoring programs at reducing opioid-related harms and consequences: a systematic review. BMC Health Serv Res. 2019;19(1):784. https://doi.org/10.1186/s12913-019-4642-8.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Liang D, Shi Y. The association between pain clinic laws and prescription opioid exposures: New evidence from multi-state comparisons. Drug Alcohol Depend. 2020;206:107754. https://doi.org/10.1016/j.drugalcdep.2019.107754.

    Article  PubMed  Google Scholar 

  21. • Pauly NJ, Slavova S, Delcher C, Freeman PR, Talbert J. Features of prescription drug monitoring programs associated with reduced rates of prescription opioid-related poisonings. Drug Alcohol Depend. 2018;184:26–32. https://doi.org/10.1016/j.drugalcdep.2017.12.002Highlights features associated with PMP success, important, given the relative lack of efficacy.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Fink DS, Schleimer JP, Sarvet A, Grover KK, Delcher C, Castillo-Carniglia A, et al. Association between prescription drug monitoring programs and nonfatal and fatal drug overdoses: a systematic review. Ann Intern Med. 168(11):783–90. https://doi.org/10.7326/M17-3074.

  23. Gourlay DL, Heit HA, Almahrezi A. Universal precautions in pain medicine: a rational approach to the treatment of chronic pain. Pain Med. 2005;6(2):107–12. https://doi.org/10.1111/j.1526-4637.2005.05031.x.

    Article  PubMed  Google Scholar 

  24. Del Fabbro E. Assessment and management of chemical coping in patients with cancer. J Clin Oncol. 2014;32(16):1734–8. https://doi.org/10.1200/JCO.2013.52.5170.

    Article  PubMed  Google Scholar 

  25. Spithoff S, Leece P, Sullivan F, Persaud N, Belesiotis P, Steiner L. Drivers of the opioid crisis: an appraisal of financial conflicts of interest in clinical practice guideline panels at the peak of opioid prescribing. PLoS One. 2020;15(1):e0227045. https://doi.org/10.1371/journal.pone.0227045.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Dowell D, Haegerich TM, Chou R. CDC guideline for prescribing opioids for chronic pain--United States, 2016. JAMA. 2016;315(15):1624–45. https://doi.org/10.1001/jama.2016.1464.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Green AR, Reifler LM, Bayliss EA, Weffald LA, Boyd CM. Drugs contributing to anticholinergic burden and risk of fall or fall-related injury among older adults with mild cognitive impairment, dementia and multiple chronic conditions: a retrospective cohort study. Drugs Aging. 2019;36(3):289–97. https://doi.org/10.1007/s40266-018-00630-z.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Alvarez CA, Mortensen EM, Makris UE, Berlowitz DR, Copeland LA, Good CB, et al. Association of skeletal muscle relaxers and antihistamines on mortality, hospitalizations, and emergency department visits in elderly patients: a nationwide retrospective cohort study. BMC Geriatr. 2015;15:2. https://doi.org/10.1186/1471-2318-15-2.

    Article  PubMed  PubMed Central  Google Scholar 

  29. • Hernandez I, He M, Brooks MM, Zhang Y. Exposure-response association between concurrent opioid and benzodiazepine use and risk of opioid-related overdose in Medicare part D beneficiaries. JAMA Netw Open. 2018;1(2):e180919. https://doi.org/10.1001/jamanetworkopen.2018.0919Elevated risk of co-medications.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Fredheim OM, Skurtveit S, Loge JH, Sjøgren P, Handal M, Hjellvik V. Prescription of analgesics to long-term survivors of cancer in early adulthood, adolescence, and childhood in Norway: a national cohort study. Pain. 2020;161(5):1083–91. https://doi.org/10.1097/j.pain.0000000000001800.

    Article  PubMed  Google Scholar 

  31. Walker BM, Ettenberg A. Benzodiazepine modulation of opiate reward. Exp Clin Psychopharmacol. 2001;9(2):191–7. https://doi.org/10.1037//1064-1297.9.2.191.

    Article  CAS  PubMed  Google Scholar 

  32. Walsh D, Perin ML, McIver B. Parenteral morphine prescribing patterns among inpatients with pain from advanced cancer: a prospective survey of intravenous and subcutaneous use. Am J Hosp Palliat Care. 2006;23(5):353–9. https://doi.org/10.1177/1049909106292170.

    Article  PubMed  Google Scholar 

  33. Chincholkar M. Gabapentinoids: pharmacokinetics, pharmacodynamics and considerations for clinical practice. Br J Pain. 2020;14(2):104–14. https://doi.org/10.1177/2049463720912496.

    Article  PubMed  Google Scholar 

  34. Okusanya BO, Asaolu IO, Ehiri JE, Kimaru LJ, Okechukwu A, Rosales C. Medical cannabis for the reduction of opioid dosage in the treatment of non-cancer chronic pain: a systematic review. Syst Rev. 2020;9(1):167. https://doi.org/10.1186/s13643-020-01425-3.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Babalonis S, Walsh SL. Therapeutic potential of opioid/cannabinoid combinations in humans: review of the evidence. Eur Neuropsychopharmacol. 2020;36:206–16. https://doi.org/10.1016/j.euroneuro.2020.03.002.

    Article  CAS  PubMed  Google Scholar 

  36. Caputi TL, Humphreys K. Medical marijuana users are more likely to use prescription drugs medically and nonmedically. J Addict Med. 2018;12(4):295–9. https://doi.org/10.1097/ADM.0000000000000405.

    Article  PubMed  Google Scholar 

  37. • Arthur JA, Reddy A, Smith U, Hui D, Park M, Liu D, et al. Practices and perceptions regarding intravenous opioid infusion and cancer pain management. Cancer. 2019;125(21):3882–9. https://doi.org/10.1002/cncr.32380Underappreciated risk related to rapid administration of intravenous opioids.

    Article  CAS  PubMed  Google Scholar 

  38. Marsch LA, Bickel WK, Badger GJ, Rathmell JP, Swedberg MD, Jonzon B, et al. Effects of infusion rate of intravenously administered morphine on physiological, psychomotor, and self-reported measures in humans. J Pharmacol Exp Ther. 2001;299(3):1056–65.

    CAS  PubMed  Google Scholar 

  39. Yu G, Zhang FQ, Tang SE, Lai MJ, Su RB, Gong ZH. Continuous infusion versus intermittent bolus dosing of morphine: a comparison of analgesia, tolerance, and subsequent voluntary morphine intake. J Psychiatr Res. 2014;59:161–6. https://doi.org/10.1016/j.jpsychires.2014.08.009.

    Article  PubMed  Google Scholar 

  40. Bohnert AS, Valenstein M, Bair MJ, Ganoczy D, McCarthy JF, Ilgen MA, et al. Association between opioid prescribing patterns and opioid overdose-related deaths. JAMA. 2011;305(13):1315–21. https://doi.org/10.1001/jama.2011.370.

    Article  CAS  PubMed  Google Scholar 

  41. Miller M, Barber CW, Leatherman S, Fonda J, Hermos JA, Cho K, et al. Prescription opioid duration of action and the risk of unintentional overdose among patients receiving opioid therapy. JAMA Intern Med. 2015;175(4):608–15. https://doi.org/10.1001/jamainternmed.2014.8071.

    Article  PubMed  Google Scholar 

  42. Fürst P, Lundström S, Klepstad P, Strang P. The use of low-dose methadone as add-on to regular opioid therapy in cancer-related pain at end of life: a national Swedish survey in specialized palliative care. J Palliat Med. 2020;23(2):226–32. https://doi.org/10.1089/jpm.2019.0253.

    Article  PubMed  Google Scholar 

  43. Furlan AD, Reardon R, Weppler C. National opioid use guideline group. Opioids for chronic noncancer pain: a new Canadian practice guideline. CMAJ. 2010;182(9):923–30. https://doi.org/10.1503/cmaj.100187.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Parsons HA, de la Cruz M, El Osta B, Li Z, Calderon B, Palmer JL, et al. Methadone initiation and rotation in the outpatient setting for patients with cancer pain. Cancer. 2010;116(2):520–8. https://doi.org/10.1002/cncr.24754.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  45. Reddy A, Yennurajalingam S, Pulivarthi K, Palla SL, Wang X, Kwon JH, et al. Frequency, outcome, and predictors of success within 6 weeks of an opioid rotation among outpatients with cancer receiving strong opioids. Oncologist. 2013;18(2):212–20. https://doi.org/10.1634/theoncologist.2012-0269.

    Article  CAS  PubMed  Google Scholar 

  46. Alpert A, Powell D, Pacula RL. Supply-side drug policy in the presence of substitutes: evidence from the Introduction of abuse-deterrent opioids. Am Econ J: Economic Policy. 2018;10(4):1–35. https://doi.org/10.1257/pol.20170082.

    Article  Google Scholar 

  47. • Arthur J, Edwards T, Reddy S, Nguyen K, Hui D, Yennu S, et al. Outcomes of a specialized interdisciplinary approach for patients with cancer with aberrant opioid-related behavior. Oncologist. 2018;23(2):263–70. https://doi.org/10.1634/theoncologist.2017-0248Effective Interdisciplinary team approach to high risk patients.

    Article  CAS  PubMed  Google Scholar 

  48. Center for Substance Abuse Treatment. Enhancing motivation for change in substance abuse treatment. Rockville (MD): Substance Abuse and Mental Health Services Administration (US); 1999. (Treatment Improvement Protocol (TIP) Series, No. 35.) Chapter 3—Motivational Interviewing as a Counseling Style. Available from: https://www.ncbi.nlm.nih.gov/books/NBK64964/

  49. Reddy A, de la Cruz M, Rodriguez EM, Thames J, Wu J, Chisholm G, et al. Patterns of storage, use, and disposal of opioids among cancer outpatients. Oncologist. 2014;19(7):780–5. https://doi.org/10.1634/theoncologist.2014-0071.

    Article  PubMed  PubMed Central  Google Scholar 

  50. • de la Cruz M, Reddy A, Balankari V, Epner M, Frisbee-Hume S, Wu J, et al. The impact of an educational program on patient practices for safe use, storage, and disposal of opioids at a comprehensive cancer center. Oncologist. 2017;22(1):115–21. https://doi.org/10.1634/theoncologist.2016-0266Simple educational pamphlet improves patient care.

    Article  CAS  PubMed  Google Scholar 

  51. Liebschutz JM, Xuan Z, Shanahan CW, LaRochelle M, Keosaian J, Beers D, et al. Improving adherence to long-term opioid therapy guidelines to reduce opioid misuse in primary care: a cluster-randomized clinical trial. JAMA Intern Med. 2017;177(9):1265–72. https://doi.org/10.1001/jamainternmed.2017.2468.

    Article  PubMed  PubMed Central  Google Scholar 

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Correspondence to Evgenia Granina.

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This article is part of the Topical Collection on Opioid Use in an Opioid Epidemic

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Granina, E., Kuzhiyil, A. & Del Fabbro, E. A Practical Approach to Assessment and Management of Patients at Risk for Non-medical Opioid Use: a Focus on the Patient with Cancer-Related Pain. Curr Anesthesiol Rep 10, 396–403 (2020). https://doi.org/10.1007/s40140-020-00417-2

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