Skip to main content

Advertisement

Log in

Extracorporeal Membrane Oxygenation for Refractory Respiratory Failure

  • Critical Care Anesthesia (LL Liu, Section Editor)
  • Published:
Current Anesthesiology Reports Aims and scope Submit manuscript

Abstract

Extracorporeal membrane oxygenation (ECMO) has been used now for more than four decades, and although initial clinical use and evidence were controversial of its benefit, technological advances in the components of the circuit, increase clinical experience, and further clinical evidence in the past decade have increased the number of centers that have employed this technology. ECMO employed as a rescue treatment for refractory respiratory failure has gained increasing support due to improvement in technology and emerging clinical evidence. The main indication for ECMO for respiratory failure is ARDS due to infection; however, recently there has been an increase in the use of ECMO for decompensated end-stage respiratory failure in patients awaiting lung transplantation. Possible contraindications for ECMO are inability to anticoagulate and the presence of malignancy. The current evidence has shown optimistic survival rates as well as quality of life that justify its use for refractory respiratory failure.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance

  1. Combes A, Bacchatta M, Brodie D, et al. Extracorporeal membrane oxygenation for respiratory failure in adults. Curr Opin Crit Care. 2012;18:99–104.

    Article  Google Scholar 

  2. ECMO Registry of the Extracorporeal Life Support Organization (ELSO) website, Ann Arbor Michigan https://elso.org. Accessed 24 July 2015.

  3. • Peek GJ, Mugford M, Tiruvoipati R, et al.; For the CESAR trial. Efficacy and economic assessmet of conventional ventilatory support versus extracorporeal membrane oxygenation for sever adult respiratory failure (CESAR): a multicentre randomized controlled trial. Lancet 2009;374:1351–63. Randomized controlled trial that evaluate mortality for respiratory failure, which showed improved mortality.

  4. • Davies A, Jones D, Bailey M, et al.; Australia and New Zealand Extracorporeal Membrane Oxygenation(ANZ ECMO) Influenza Investigators. Extracorporeal membrane oxygenation for 2009 influenza A (H1N1) acute respiratory distress syndrome. JAMA. 2009;302(17):1888–95. Randomized controlled trial that evaluated the use of ECMO during the influenza pandemia of 2009.

  5. Murray JF, Matthay MA, Luce JM, et al. An expanded definition of the adult respiratory distress syndrome. Am Rev Respir Dis. 1988;138(3):720–3.

    Article  CAS  Google Scholar 

  6. Rubenfeld GD, For the ARDS Definition Task Force. Acute respiratory distress syndrome: the Berlin definition. JAMA. 2012;307(23):2526–33.

    CAS  PubMed  Google Scholar 

  7. Schmidt M, Bailey M, Sheldrake J, et al. Predicting survival after extracorporeal membrane oxygenation in severe acute respiratory failure, the respiratory extracorporeal membrane oxygenation survival (RESP) score. AJRCCM. 2014;189:1374–82.

    Google Scholar 

  8. Veith FJ. Lung transplantation. Transplant Proc. 1977;9(1):203–8.

    CAS  PubMed  Google Scholar 

  9. Hoopes CW, Kukreja J, Golden J. Extracorporeal membrane oxygenation as a bridge to pulmonary transplantation. J Thorac Cardiovasc Surg. 2013;145:682–7.

    Article  Google Scholar 

  10. Tayama E, Hayashida N, Akasu K, et al. Biocompatibility of heparin-coated extracorporeal bypass circuits: new heparin bonded bioline system. Artif Organs. 2000;24:618–23.

    Article  CAS  Google Scholar 

  11. Hemmila MR, Rowe SA, Boules TN, et al. Extracorporeal life support for severe acute respiratory distress syndrome in adults. Ann Thorac Surg. 2004;240:595–605.

    Google Scholar 

  12. Aubron C, Cheng AC, Pilcher D et al: Factors associated with outcomes of patients on extracorporeal membrane oxygenation support: a 5-year cohort study. Crit Care. 2013;17:R73. http://ccforum.com/content/17/2/R73.

  13. Jones N, Harris S, Cordle C. Long-term results of ECMO for adult respiratory failure. In: Van Meurs K, Lally KP, Peek GJ, et al., editors. ECMO extracorporeal cardiopulmonary support in critical care. 3rd ed. Ann Arbor: Extracorporeal Life Support Organization; 2005. p. 417–30.

    Google Scholar 

  14. Schmidt M, Zogheib E, Roze H. The PRESERVE mortality risk score and analysis of long-term outcomes after extracorporeal membrane oxygenation for severe acute respiratory distress syndrome. Int Care Med. 2013;39(10):1704–13.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Andres Oswaldo Razo Vazquez.

Additional information

This article is part of the Topical Collection on Critical Care Anesthesia.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Razo Vazquez, A., Ramsay, J. Extracorporeal Membrane Oxygenation for Refractory Respiratory Failure. Curr Anesthesiol Rep 5, 380–386 (2015). https://doi.org/10.1007/s40140-015-0139-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40140-015-0139-0

Keywords

Navigation