Targeting Pericytes to Improve Wound Healing Outcomes
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Purpose of Review
Recently, pericytes, a mesenchymal stem-like cell population, has been of great interest due to its plasticity and for its role in different pathologies. This review will focus on the contributions of pericytes specifically to wound healing and the potential to manipulate this specific cell population for better healing outcome.
Several studies point towards the capability of pericytes to regulate inflammation, angiogenesis and the remodeling phase of healing. Interestingly, findings also show that the source from which pericytes are isolated has differential and varied effects during the process of healing. Pericytes have proven to be beneficial in healing both acute and chronic wounds.
Pericytes have both mesenchymal stem cell-like property and its own signature in regulating signaling cascades and molecules making it a prime candidate for cellular therapy. Several other functions of pericytes are still being explored to further understand its potential for use in therapeutic applications.
KeywordsPericytes Fibrosis Wounds Inflammation Myofibroblast
We thank Mr. Alexander Evdokiou, Shriners Hospitals for Children-Cincinnati, for helpful discussion and comments. We thank Ms. Claudia Roth, Shriners Hospitals for Children-Cincinnati, for her assistance in preparing Fig. 1.
Compliance with Ethical Standards
Conflict of Interest
The authors have no conflict of interest to declare.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
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