Skip to main content

Advertisement

Log in

Central Retinal Artery Occlusion

  • Published:
Current Emergency and Hospital Medicine Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

This review aims to provide a comprehensive overview of emergency department management of central retinal artery occlusion (CRAO). It examines common presentations, etiologies, workup, and various treatment options with their evidence.

Recent Findings

There is limited research on CRAO. Most treatment methods and guidelines are based on observational literature, case series, retrospective studies, and expert opinion. Many of the treatments available to the emergency provider have limited success. More advanced treatments with hyperbaric therapy or thrombolytics are becoming more established.

Summary

Workup for CRAO should focus on establishing the etiology of the event. There are many treatment options available to the emergency provider, including emergent hyperbaric oxygen therapy and thrombolytics. Emergency department care should occur in conjunction with ophthalmology and neurology. Much of the treatment is guided towards preventing future cardiovascular events.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance

  1. Leavitt JA, Larson TA, Hodge DO, Gullerud RE. The incidence of central retinal artery occlusion in Olmsted County, Minnesota. Am J Ophthalmol. 2011 ;152(5):820–3.e2. https://doi.org/10.1016/j.ajo.2011.05.005. Epub 2011 Jul 27. PMID: 21794842; PMCID: PMC3326414.

  2. Greven CM, Slusher MM, Weaver RG. Retinal arterial occlusions in young adults. Am J Ophthalmol. 1995;120(6):776–83. ISSN 0002-9394. https://doi.org/10.1016/s0002-9394(14)72731-x.

  3. • Schumacher M, Schmidt D, Jurklies B, Gall C, Wanke I, Schmoor C, Maier-Lenz H, Solymosi L, Brueckmann H, Neubauer AS, et al. EAGLE-Study Group. Central retinal artery occlusion: local intra-arterial fibrinolysis versus conservative treatment, a multicenter randomized trial. Ophthalmology. 2010; 117:1367–75.e1. https://doi.org/10.1016/j.ophtha.2010.03.061. Randomized trial evaluating intravenous thrombolysis for CRAO.

  4. • Schorr EM, Rossi KC, Stein LK, Park BL, Tuhrim S, Dhamoon MS. Characteristics and outcomes of retinal artery occlusion: nationally representative data. Stroke. 2020; 51:800–807. https://doi.org/10.1161/STROKE119027034. Discusses comorbidities, interventions, and outcomes for patients with retinal artery occlusion.

  5. • Chodnicki KD,  Pulido JS, Hodge DO, Klaas JP, Chen JJ. Stroke risk before and after central retinal artery occlusion in a US cohort. Mayo Clin Proc. 2019;94(2):236-241. ISSN 0025-6196. https://doi.org/10.1016/j.mayocp.2018.10.018. Discusses relationship between CRAO and stroke.

  6. Hayreh SS. Orbital vascular anatomy. Eye (Lond). 2006;20(10):1130–44. https://doi.org/10.1038/sj.eye.6702377. PMID: 17019411.

    Article  CAS  PubMed  Google Scholar 

  7. Hayreh SS, Zimmerman MB. Central retinal artery occlusion: visual outcome. Am J Ophthalmol. 2005;140(3):376–91. https://doi.org/10.1016/j.ajo.2005.03.038. PMID: 16138997.

    Article  PubMed  Google Scholar 

  8. https://www.ahajournals.org/doi/10.1161/STR.0000000000000366#d5155393e1308_copied.

  9. Hayreh SS, Podhajsky PA, Zimmerman MB. Retinal artery occlusion: associated systemic and ophthalmic abnormalities. Ophthalmology. 2009;116(10):1928–36. https://doi.org/10.1016/j.ophtha.2009.03.006. Epub 2009 Jul 3. PMID: 19577305; PMCID: PMC2757505.

  10. Babikian V, Wijman CA, Koleini B, Malik SN, Goyal N, Matjucha IC. Retinal ischemia and embolism. Etiologies and outcomes based on a prospective study. Cerebrovasc Dis. 2001;12(2):108–13. https://doi.org/10.1159/000047689. PMID: 11490104.

  11. Hayreh SS. Giant cell arteritis: its ophthalmic manifestations. Indian J Ophthalmol. 2021;69(2):227–35. https://doi.org/10.4103/ijo.IJO_1681_20.PMID:33463564;PMCID:PMC7933845.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Mokhtari F, Massin P, Paques M, Biousse V, Houdart E, Blain P, Gaudric A. Central retinal artery occlusion associated with head or neck pain revealing spontaneous internal carotid artery dissection. Am J Ophthalmol. 2000;129(1):108–9. https://doi.org/10.1016/s0002-9394(99)00318-9. PMID: 10653429.

    Article  CAS  PubMed  Google Scholar 

  13. Warrasak S, Tapaneya-Olarn W, Euswas A, Sriphojanart S, Sirikulchayanonta V, Leelachaikul P. Fibromuscular dysplasia: a rare cause of cilioretinal artery occlusion in childhood. Ophthalmology. 2000;107(4):737–41. https://doi.org/10.1016/s0161-6420(99)00147-5. PMID: 10768337.

    Article  CAS  PubMed  Google Scholar 

  14. Sher NA, Reiff W, Letson RD, Desnick RJ. Central retinal artery occlusion complicating Fabry’s disease. Arch Ophthalmol. 1978;96(5):815–7. https://doi.org/10.1001/archopht.1978.03910050421003. PMID: 207248.

    Article  CAS  PubMed  Google Scholar 

  15. Mansi IA, Alkhunaizi AM, Al-Khatti AA. Bilateral central retinal artery occlusion secondary to sickle cell disease. Am J Hematol. 2000;64(1):79–80. https://doi.org/10.1002/(sici)1096-8652(200005)64:13.0.co;2-c. PMID: 10815797.

  16. Brown GC, Shields JA. Cilioretinal arteries and retinal arterial occlusion. Arch Ophthalmol. 1979;97(1):84–92. https://doi.org/10.1001/archopht.1979.01020010024006. PMID: 758898.

    Article  CAS  PubMed  Google Scholar 

  17. Yuzurihara D, Iijima H. Visual outcome in central retinal and branch retinal artery occlusion. Jpn J Ophthalmol. 2004;48(5):490–2. https://doi.org/10.1007/s10384-004-0102-y. PMID: 15486774.

  18. Hayreh SS, Zimmerman MB. Fundus changes in central retinal artery occlusion. Retina. 2007;27(3):276–89. https://doi.org/10.1097/01.iae.0000238095.97104.9b. PMID: 17460582.

    Article  PubMed  Google Scholar 

  19. Sharma S, Brown GC, Pater JL, Cruess AF. Does a visible retinal embolus increase the likelihood of hemodynamically significant carotid artery stenosis in patients with acute retinal arterial occlusion? Arch Ophthalmol. 1998;116(12):1602–6. https://doi.org/10.1001/archopht.116.12.1602.

    Article  CAS  PubMed  Google Scholar 

  20. https://commons.wikimedia.org/wiki/File:Cherry_red_spot_in_patient_with_central_retinal_artery_occlusion_(CRAO).jpg

  21. Varma DD, Cugati S, Lee AW, Chen CS. A review of central retinal artery occlusion: clinical presentation and management. Eye (Lond). 2013;27(6):688–97. https://doi.org/10.1038/eye.2013.25. Epub 2013 Mar 8. PMID: 23470793; PMCID: PMC3682348.

  22. David NJ, Norton EW, Gass JD, Beauchamp J. Fluorescein angiography in central retinal artery occlusion. Arch Ophthalmol. 1967;77(5):619–29. https://doi.org/10.1001/archopht.1967.00980020621010. PMID: 6022731.

    Article  CAS  PubMed  Google Scholar 

  23. Smetana GW, Shmerling RH. Does this patient have temporal arteritis? JAMA. 2002;287(1):92–101. https://doi.org/10.1001/jama.287.1.92. PMID: 11754714.

    Article  PubMed  Google Scholar 

  24. Gonzalez-Gay MA, Lopez-Diaz MJ, Barros S, Garcia-Porrua C, Sanchez-Andrade A, Paz-Carreira J, Martin J, Llorca J. Giant cell arteritis: laboratory tests at the time of diagnosis in a series of 240 patients. Medicine (Baltimore). 2005;84(5):277–90. https://doi.org/10.1097/01.md.0000180043.19285.54. PMID: 16148728.

    Article  PubMed  Google Scholar 

  25. Chen CS, Lee AW, Campbell B, Lee T, Paine M, Fraser C, Grigg J, Markus R. Efficacy of intravenous tissue-type plasminogen activator in central retinal artery occlusion: report from a randomized, controlled trial. Stroke. 2011;42(8):2229–34. https://doi.org/10.1161/STROKEAHA.111.613653. Epub 2011 Jul 14. PMID: 21757667.

  26. Fraser SG, Adams W. Interventions for acute non-arteritic central retinal artery occlusion. Cochrane Database Syst Rev. 2009;2009(1):CD001989. https://doi.org/10.1002/14651858.CD001989.pub2. PMID: 19160204; PMCID: PMC7081130.

  27. Rudkin AK, Lee AW, Aldrich E, Miller NR, Chen CS. Clinical characteristics and outcome of current standard management of central retinal artery occlusion. Clin Exp Ophthalmol. 2010;38(5):496–501. https://doi.org/10.1111/j.1442-9071.2010.02280.x. Epub 2010 Mar 2 PMID: 20584027.

    Article  PubMed  Google Scholar 

  28. • Cugati S, Varma DD, Chen CS, Lee AW. Treatment options for central retinal artery occlusion. Curr Treat Options Neurol. 2013;15(1):63–77 https://doi.org/10.1007/s11940-012-0202-9Comprehensive review on the options available in treatment of CRAO, from conservative to pharmacologic to invasive.

  29. Rumelt S, Dorenboim Y, Rehany U. Aggressive systematic treatment for central retinal artery occlusion. Am J Ophthalmol. 1999;128(6):733–8. https://doi.org/10.1016/s0002-9394(99)00359-1.Erratum.In:AmJOphthalmol2000Dec;130(6):908. PMID: 10612510.

    Article  CAS  PubMed  Google Scholar 

  30. Incandela L, Cesarone MR, Belcaro G, Steigerwalt R, De Sanctis MT, Nicolaides AN, et al. Treatment of vascular retinal disease with pentoxifylline: a controlled, randomized trial. Angiology. 2002;53(Suppl 1):31–4.

    Google Scholar 

  31. Atebara NH, Brown GC, Cater J. Efficacy of anterior chamber paracentesis and carbogen in treating acute nonarteritic central retinal artery occlusion. Ophthalmology. 1995;102:2029–34.

    Article  CAS  PubMed  Google Scholar 

  32. Dollery CT, Bulpitt CJ, Kohner EM. Oxygen supply to the retina from the retinal and choroidal circulations at normal and increased arterial oxygen tensions. Invest Ophthalmol. 1969; 8:588–594.

  33. Beiran I, Goldenberg I, Adir Y, Tamir A, Shupak A, Miller B. Early hyperbaric oxygen therapy for retinal artery occlusion. Eur J Ophthalmol. 2001;11(4):345–50. https://doi.org/10.1177/112067210101100405.

    Article  CAS  PubMed  Google Scholar 

  34. Hertzog LM, Meyer GW, Carson S, Strauss MB, Hart GB. Central retinal artery occlusion treated with hyperbaric oxygen. J Hyperb Med. 1992;7:33–42.

    Google Scholar 

  35. • Lopez AS, Basto R, Henriques S, et al. Hyperbaric oxygen therapy in retinal arterial occlusion: epidemiology, clinical approach, and visual outcomes. Case Rep Ophthalmol Med. 2019;2019:9765938. Published 2019 Dec 28. https://doi.org/10.1155/2019/9765938. Discusses outcomes of CRAO patients treated with HBO therapy.

  36. Wu X, Chen S, Li S, Zhang J, Luan D, Zhao S, Chu Z, Xu Y. Oxygen therapy in patients with retinal artery occlusion: a meta-analysis. PLoS One. 2018;13(8):e0202154. https://doi.org/10.1371/journal.pone.0202154. PMID: 30157206; PMCID: PMC6114710.

  37. Johnson DR, Cooper JS. Retinal artery and vein occlusions successfully treated with hyperbaric oxygen. Clin Pract Cases Emerg Med. 2019;3(4):338–40. https://doi.org/10.5811/cpcem.2019.7.43017.PMID:31763582;PMCID:PMC6861035.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Wright J, Franklin B, Zant E. Clinical case report: treatment of a central retinal vein occlusion with hyperbaric oxygen. Undersea Hyperb Med. 2007;34(5):315–9.

    CAS  PubMed  Google Scholar 

  39. Hwang CK, Kolomeyer AM, Brucker AJ. Optical coherence tomography angiography of a central retinal artery occlusion before and after anterior chamber paracentesis.

  40. Fieß A, Cal Ö, Kehrein S, Halstenberg S, Frisch I, Steinhorst UH. Anterior chamber paracentesis after central retinal artery occlusion: a tenable therapy? BMC Ophthalmol. 2014;14:28.

    Article  PubMed  PubMed Central  Google Scholar 

  41. Schrag M, Youn T, Schindler J, Kirshner H, Greer D. Intravenous fibrinolytic therapy in central retinal artery occlusion: a patient-level meta-analysis. JAMA Neurol. 2015;72:1148–1154. https://doi.org/10.1001/jamaneurol.2015.1578

  42. Richard G, Lerche RC, Knospe V, Zeumer H. Treatment of retinal arterial occlusion with local fibrinolysis using recombinant tissue plasminogen activator. Ophthalmology. 1999;106(4):768–73. https://doi.org/10.1016/S0161-6420(99)90165-3. PMID: 10201601.

    Article  CAS  PubMed  Google Scholar 

  43. Weber J, Remonda L, Mattle HP, Koerner U, Baumgartner RW, Sturzenegger M, Ozdoba C, Koerner F, Schroth G. Selective intra-arterial fibrinolysis of acute central retinal artery occlusion. Stroke. 1998;29(10):2076–9. https://doi.org/10.1161/01.str.29.10.2076. PMID: 9756585.

    Article  CAS  PubMed  Google Scholar 

  44. Beatty S, Au Eong KG. Local intra-arterial fibrinolysis for acute occlusion of the central retinal artery: a meta-analysis of the published data. Br J Ophthalmol. 2000;84(8):914–6. https://doi.org/10.1136/bjo.84.8.914.PMID:10906103;PMCID:PMC1723600.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  45. Vu HT, Keeffe JE, McCarty CA, Taylor HR. Impact of unilateral and bilateral vision loss on quality of life. Br J Ophthalmol. 2005;89:360–3. https://doi.org/10.1136/bjo.2004.047498.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. Chia EM, Mitchell P, Rochtchina E, Foran S, Wang JJ. Unilateral visual impairment and health related quality of life: the Blue Mountains Eye Study. Br J Ophthalmol. 2003; 87:392–395. https://doi.org/10.1136/bjo.87.4.392

  47. Kramer M, Goldenberg-Cohen N, Shapira Y, Axer-Siegel R, Shmuely H, Adler Y, Weinberger D, Sagie A. Role of transesophageal echocardiography in the evaluation of patients with retinal artery occlusion. Ophthalmology. 2001;108(8):1461–4. https://doi.org/10.1016/s0161-6420(01)00641-8. PMID: 11470701.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Kinjal Sethuraman.

Ethics declarations

Conflict of Interest

The authors declare no competing interests.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subject performed by any of the authors.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lescure, D., Sethuraman, K. Central Retinal Artery Occlusion. Curr Emerg Hosp Med Rep 11, 198–206 (2023). https://doi.org/10.1007/s40138-023-00275-2

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40138-023-00275-2

Keywords

Navigation