Skip to main content
Log in

The Role of Steroids in Performing Voice

  • REVIEW
  • Published:
Current Otorhinolaryngology Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

This review seeks to illuminate the challenges that arise in the use of steroids in the context of a performing voice, to review pharmacologic principles that can help to guide dosing regimens, to examine emerging science about the mechanistic action of glucocorticoids, and to provide a useful guide for clinicians who treat vocal performers.

Recent Findings

Though perceptions and mythologies abound, most saliently (1) the incidence of vocal fold hemorrhage while taking oral steroids is extremely low; (2) appropriate dosing is likely to involve regimens that meet or exceed 30 mg oral Prednisone-equivalent daily to address edema acutely; (3) tapering after short courses may well be unnecessary.

Summary

Steroids can be used safely and judiciously to treat vocal performers, guided by physical examination, sound clinical judgment, and a multidisciplinary approach to the individual needs of each unique voice and performer.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance

  1. Govil N, Paul BC, Amin MR, Branski RC. The utility of glucocorticoids for vocal fold pathology: a survey of otolaryngologists. J Voice. 2013;28:82–7. https://doi.org/10.1016/j.jvoice.2013.04.015.

    Article  PubMed  Google Scholar 

  2. Rafii B, Sridharan S, Taliercio S, Govil N, Paul B, Garabedian MJ, Amin MR, Branski RC. Glucocorticoids in laryngology: a review. Laryngoscope. 2014;124:1668–73. https://doi.org/10.1002/lary.24556.

    Article  CAS  PubMed  Google Scholar 

  3. Estes CM, Chadwick K, Sadoughi B, Andreadis K, Sussman S, Sulica L. Prospective evaluation of safety of singing on steroids: testing the truth of received wisdom. Laryngoscope. 2021;131:2298–304. https://doi.org/10.1002/lary.29437.

    Article  Google Scholar 

  4. • Amin MR, Achlatis S, Gherson S, Fang Y, Wang B, Born H, Branski RC, Johnson AM. The role of oral steroids in the treatment of phonotraumatic vocal fold lesions in women. Otolaryngol Head Neck Surg. 2019;160:512–8. https://doi.org/10.1177/0194599818804776. One of the first investigations to examine in a systematic way the effects of steroids on both acoustic and aerodynamic measures and laryngoscopic findings.

    Article  PubMed  Google Scholar 

  5. Ingle JW, Helou LB, Li NYK, Hebda PA, Rosen CA, Abbott KV. Role of steroids in acute phonotrauma: a basic science investigation. Laryngoscope. 2014;124:921–7. https://doi.org/10.1002/lary.23691.

    Article  CAS  PubMed  Google Scholar 

  6. Czock D, Keller F, Rasche FM, Haussler U. Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids. Clin Pharmacokinet. 2005;44(1):61–98. https://doi.org/10.2165/00003088-200544010-00003.

    Article  CAS  PubMed  Google Scholar 

  7. Buttgereit F, Straub RH, Wehling M, Burmester GR. Glucocorticoids in the treatment of rheumatic diseases: an update on the mechanisms of action. Arthritis Rheum. 2004;50(11):3408–17. https://doi.org/10.1002/art.20583.

    Article  CAS  PubMed  Google Scholar 

  8. Panettieri RA, Schaafsma D, Amrani Y, Koziol-White C, Ostrom R, Tliba O. Non-genomic effects of glucocorticoids: an updated view. Trends Pharmacol Sci. 2019;40(1):38–49. https://doi.org/10.1016/j.tips.2018.11.002.

    Article  CAS  PubMed  Google Scholar 

  9. • Strehl CS, Spies CM, Buttgereit F. Pharmacodynamics of glucocorticoids. Clin Exp Rheumatol. 2011;29(68):13–18. A foundational text in understanding the molecular and cellular underpinnings of corticosteroid action, and therefore the dosing and tapering regimens suggested in this review.

  10. Frew A. Glucocorticoids. In: Rich R, ed. Clin Immunol: Princ Pract. 2019;5.

  11. Nakamura R, Bing R, Gartling GJ, Garabedian MJ, Branski RC. Glucocorticoid dose dependency on gene expression in vocal fold fibroblasts and macrophages. Laryngoscope. 2022. https://doi.org/10.1002/lary.30330.

    Article  PubMed  Google Scholar 

  12. • Poetker DM, Reh DD. A comprehensive review of the adverse effects of systemic corticosteroids. Otolaryngol Clin North Am. 2010;43(4):753–68. https://doi.org/10.1016/j.otc.2010.04.003. An excellent review of adverse effects from systemic corticosteroids.

    Article  PubMed  Google Scholar 

  13. Fardet L, Kassar A, Cabane J, Flauhault A. Corticosteroid-induced adverse events in adults: frequency, screening, and prevention. Drug Safety. 2007;30(10):861–881.

  14. Chrouos GP. Adrenocorticosteroids and adrenocortical antagonists. In: B.G. K, ed. Basic Clin Pharmacol. 2017. McGraw-Hill.

  15. Oelkers W. Adrenal insufficiency New England Med. 1996;335:1206–12.

    Article  CAS  Google Scholar 

  16. LaRochelle GE, LaRochelle AG, Ratner RE, Borenstein DG. Recovery of the hypothalamic-pituitary-adrenal (HPA) axis in patients with rheumatic disease receiving low-dose prednisone. Am J Med. 1993;95:258–264.

  17. Wilson AM, McFarlane LC, Lipworth BJ. Systemic bioactivity profiles of oral prednisolone and nebulized budesonide in adult asthmatics. Chest. 1998;114(4):1022–7. https://doi.org/10.1378/chest.114.4.1022.

    Article  CAS  PubMed  Google Scholar 

  18. Brigell DF, Fang VS, Rosenfield RL. Recovery of responses to ovine corticotropin-releasing hormone after withdrawal of a short course of glucocorticoid. J Clin Endocrinol Metab. 1992;74(5):1036–9.

    CAS  PubMed  Google Scholar 

  19. Prete A, Bancos I. Glucocorticoid induced adrenal insufficiency. BMJ. 2021;374: n1380. https://doi.org/10.1136/bmj.n1380.

    Article  PubMed  Google Scholar 

  20. Broersen LH, Pereira AM, Jorgensen JO, Dekkers OM. Adrenal insufficiency in corticosteroids use: systematic review and meta-analysis. J Clin Endocrinol Metab. 2015;100(6):2171–80. https://doi.org/10.1210/jc.2015-1218.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Contributions

P.K. and T.W. wrote the main manuscript text. R.B. made significant revisions and contributions to the manuscript. All authors finally reviewed the manuscript.

Corresponding author

Correspondence to Paul E. Kwak.

Ethics declarations

Competing Interests

The authors declare no competing interests.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kwak, P.E., Crosby, T. & Branski, R.C. The Role of Steroids in Performing Voice. Curr Otorhinolaryngol Rep 12, 11–16 (2024). https://doi.org/10.1007/s40136-023-00498-7

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40136-023-00498-7

Keywords

Navigation