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Central Compartment Atopic Disease: What Are the Defining Clinical Features?

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Abstract

Purpose of Review

The goal of this narrative is to educate clinicians on the pathophysiology, clinical presentation, radiologic findings, and treatment strategies of central compartment atopic disease.

Recent Findings

Central compartment atopic disease (CCAD) is a relatively recently described chronic rhinosinusitis phenotype involving polypoid changes of central sinonasal compartment related to inhalant allergy exposure. This review highlights the current understanding of the pathophysiology of CCAD, relevant history, physical exam findings, and radiologic hallmarks in order to allow for appropriate clinical management.

Summary

CCAD is a diffuse type 2-mediated inflammatory phenotype that initially includes polypoid changes of central sinonasal compartment. This is a response to inhalant allergen deposition in the area. Initial treatment includes management of their allergy via immunotherapy. In cases with sinus obstruction from edema of the central compartment, management includes endoscopic sinus surgery. There are differing views on the extent of surgery for these patients.

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Authors and Affiliations

  1. Department of Otolaryngology Head and Neck Surgery, University of Alabama Birmingham, FOT 1155, 1720 2nd Ave South, Birmingham, AL, 35294, USA

    Emily Miller, Do-Yeon Cho, Bradford A. Woodworth & Jessica W. Grayson

  2. Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama, Birmingham, USA

    Do-Yeon Cho & Bradford A. Woodworth

  3. Division of Otolaryngology Head and Neck Surgery, Department of Veterans Affairs, Birmingham, AL, USA

    Bradford A. Woodworth

Authors
  1. Emily Miller
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  2. Do-Yeon Cho
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  3. Bradford A. Woodworth
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  4. Jessica W. Grayson
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Corresponding author

Correspondence to Jessica W. Grayson.

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Competing Interests

Emily Miller, MD, has no relevant disclosures. Do-Yeon Cho, MD, has no relevant disclosures. Bradford A, Woodworth, MD, serves as a consultant for Medtronic and Cook Medical. Jessica Grayson, MD, has no relevant disclosures.

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Miller, E., Cho, DY., Woodworth, B.A. et al. Central Compartment Atopic Disease: What Are the Defining Clinical Features?. Curr Otorhinolaryngol Rep 11, 452–457 (2023). https://doi.org/10.1007/s40136-023-00492-z

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  • DOI: https://doi.org/10.1007/s40136-023-00492-z

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