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Malignant Primary Neoplasms of the Nasal Cavity and Paranasal Sinus

  • Paranasal Sinus Tumors (P Bradley, Section Editor)
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Abstract

Purpose of Review

Malignant primary neoplasms of the sinonasal cavities are rare, comprising 3–5 % of all head and neck cancers. This manuscript reviews and describes the unique aspects of the epidemiology, histopathologic and clinicopathologic characteristics, as well as treatment options for the more commonly encountered sinonasal malignancies.

Recent Findings

In the recent past, population-based studies have further expanded our knowledge about these cancers. In the past decade, endoscopic endonasal surgery has become the treatment of choice for a significant number of cases, reported from major academic centers throughout the world. In many instances, there is a role for adjunct treatment modalities such as radiotherapy and chemotherapy. More recently however, molecular-targeted therapies in the form of monoclonal antibodies have also entered the mix and are generating, as yet unproven, exciting prospects.

Summary

Malignant primary neoplasms of the sinonasal cavity are rare tumors that are difficult to treat. The best outcome is most likely to be achieved by a multidisciplinary treatment approach.

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Authors and Affiliations

  1. Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, 90 Bergen St., Suite 8100, Newark, NJ, 07103, USA

    Suat Kilic, Soly Baredes, James K. Liu & Jean Anderson Eloy

  2. Department of Radiology, Icahn School of Medicine at the Mount Sinai Hospital System, Mount Sinai Beth Israel, First Avenue at Sixteenth Street, New York, NY, 10010, USA

    Pratik A. Shukla

  3. Department of Otolaryngology-Head and Neck Surgery, University of Michigan Health System Ann Arbor, Michigan, USA

    Emily J. Marchiano

  4. Department of Radiology, Brown University Medicine School, 593 Eddy Street, Providence, RI, 02903, USA

    Ronak H. Patel

  5. Center for Skull Base and Pituitary Surgery, Rutgers New Jersey Medical School, Neurological Institute of New Jersey, 90 Bergen St., Suite 8100, Newark, NJ, 07103, USA

    Soly Baredes, James K. Liu & Jean Anderson Eloy

  6. Department of Neurological Surgery, Rutgers New Jersey Medical School, 90 Bergen St., Suite 8100, Newark, NJ, 07103, USA

    James K. Liu & Jean Anderson Eloy

  7. Department of Ophthalmology and Visual Science, Rutgers New Jersey Medical School, 90 Bergen St., Suite 8100, Newark, NJ, 07103, USA

    Jean Anderson Eloy

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  1. Suat Kilic
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  6. James K. Liu
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Correspondence to Suat Kilic, Pratik A. Shukla, Emily J. Marchiano, Ronak H. Patel, Soly Baredes, James K. Liu or Jean Anderson Eloy.

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Suat Kilic, Dr. Pratik A. Shukla, Dr. Emily J. Marchiano, Dr. Ronak H. Patel, Dr. Soly Baredes, Dr. James K. Liu, and Dr. Jean Anderson Eloy declare that they have no conflict of interest.

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All reported studies/experiments with human or animal subjects performed by the authors have been previously published and complied with all applicable ethical standards (including the Helsinki declaration and its amendments, institutional/national research committee standards, and international/national/institutional guidelines).

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This article is part of the Topical Collection on Paranasal Sinus Tumors

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Kilic, S., Shukla, P.A., Marchiano, E.J. et al. Malignant Primary Neoplasms of the Nasal Cavity and Paranasal Sinus. Curr Otorhinolaryngol Rep 4, 249–258 (2016). https://doi.org/10.1007/s40136-016-0134-0

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