Chronic Rhinosinusitis-Related Smell Loss: Medical and Surgical Treatment Efficacy
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Chronic rhinosinusitis (CRS) is an inflammatory disorder of the nasal cavities and paranasal sinuses. Olfactory dysfunction is a common manifestation of CRS and one of its cardinal diagnostic features. A decreased sense of smell can have a profound impact on a CRS patient’s quality of life and overall wellbeing. The treatment of CRS-associated olfactory dysfunction includes a wide range of medical interventions, including anti-inflammatory and antibiotic medications, and surgical interventions, including endoscopic sinus and nasal surgery. The evidence and treatment efficacy for these interventions is quite varied. This review provides a summary of the efficacy of the medical and surgical therapeutic options for CRS-associated olfactory dysfunction.
KeywordsOlfaction Smell loss Anosmia Chronic rhinosinusitis Olfactory dysfunction Endoscopic sinus surgery
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Conflict of Interest
Dr. David A. Gudis declares that he has no conflict of interest. Dr. Zachary M. Soler reports personal fees from Olympus, outside the submitted work.
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This article does not contain any studies with human or animal subjects performed by any of the authors.
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- 4.• Banglawala SM, et al. Olfactory outcomes in chronic rhinosinusitis with nasal polyposis after medical treatments: a systematic review and meta-analysis. Int Forum Allergy Rhinol. 2014;4:986–94. Excellent systematic review of medical therapy outcomes for olfactory function in patients with chronic rhinosinusitis with polyposis. Google Scholar
- 6.• Soler ZM, Mace J, Smith TL. Symptom-based presentation of chronic rhinosinusitis and symptom-specific outcomes after endoscopic sinus surgery. Am J Rhinol. 2008;22:297–301. A thorough investigation into which symptoms of chronic rhinosinusitis improve and to what degree in response to surgical therapy. Google Scholar
- 21.• Litvack JR, Mace JC, Smith TL. Olfactory function and disease severity in chronic rhinosinusitis. Am J Rhinol Allergy. 2009;23:139–44. A concise investigation into the relationship between olfactory function and chronic rhinosinusitis disease severity. Google Scholar
- 22.• Litvack JR, Mace J, Smith TL. Does olfactory function improve after endoscopic sinus surgery? Otolaryngol Head Neck Surg. 2009;140:312–9. Perhaps the most definitive study to date investigating not only the response of olfactory function to surgical management for chronic rhinosinusitis, but the importance of preoperative olfactory function. Google Scholar
- 45.Penttila M, Poulsen P, Hollingworth K, Holmstrom M. Dose-related efficacy and tolerability of fluticasone propionate nasal drops 400 mug once daily and twice daily in the treatment of bilateral nasal polyposis: a placebo-controlled randomized study in adult patients. Clin Exp Allergy. 2000;30:94–102.CrossRefPubMedGoogle Scholar