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Table 4 Risk factors of all-cause one-year mortality

From: Genetic Risk Surveillance for Invasive Aspergillosis in Hematology Patients: A Prospective Observational Study

Risk factors Survived, n = 363 admission episodes (%) Dead, n = 53 admission episodes (%) Univariate Cox regression HR (95% CI), P value Multivariate Cox regression HR (95% CI), P value
Female 159 (43.8) 24 (45.3) 1.110 (0.647–1.907), 0.704  
> 60 years old 100 (27.5) 24 (45.3) 1.972 (1.148–3.388), 0.014 2.313 (1.209–4.426), 0.011
At risk occupationa 25 (8.5) 3 (6.4) 0.667 (0.207–2.151), 0.498  
Current smoking 11 (3.7) 5 (10.4) 2.153 (0.852–5.437), 0.105  
Prior invasive mold disease 7 (2.3) 1 (2.1) 0.933 (0.129–6.768), 0.945  
Diabetes 34 (11.2) 8 (16.3) 1.264 (0.592–2.701), 0.545  
Corticosteroids 66 (22.5) 8 (17.4) 0.763 (0.356–1.636), 0.487  
Lymphocytopenia or anti-T cell use 44 (15.1) 13 (27.1) 1.859 (0.982–3.520), 0.057  
Prolonged neutropenia 44 (15.1) 19 (39.6) 2.904 (1.626–5.187), < 0.001 3.240 (1.663–6.312), 0.001
Mucositis, grade 3–4 9 (3.1) 4 (8.3) 2.335 (0.839–6.501), 0.105  
CMV infection 10 (3.4) 6 (12.5) 2.624 (1.113–6.187), 0.028 2.077 (0.777–5.552), 0.145
Admitted in non-HEPA room 164 (64.3) 29 (64.4) 1.125 (0.609–2.076), 0.707  
High-risk malignancyb 91 (25.2) 19 (35.8) 1.460 (0.833–2.561), 0.186  
Uncontrolled malignancyc 202 (68.2) 42 (87.5) 3.374 (1.433–7.944), 0.005 2.661 (1.039–6.813), 0.041
High-risk chemotherapyd 63 (21.1) 14 (29.2) 0.879 (0.499–1.550), 0.656  
Antifungal prophylaxis 35 (11.9) 1 (2.1) 0.178 (0.025–1.290), 0.088  
DC-SIGNrs4804800 G/G genotype 49 (14.4) 5 (9.8) 0.718 (0.285–1.808), 0.482  
DC-SIGNrs4804800 G carriage 186 (54.7) 32 (62.7) 1.277 (0.724–2.253), 0.399  
IL10rs1800896 C/C genotype 0 (0) 1 (2.0)
IL10rs1800896 C carriage 35 (10.4) 11 (21.6) 2.275 (1.166–4.441), 0.016 1.770 (0.881–3.554), 0.109
  1. HR hazard ratio, CMV cytomegalovirus, HEPA high efficiency particulate air filter, DC-SIGN dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin, IL10 interleukin-10, DECTIN1 dendritic cell-associated c-type lectin 1, TLR4 Toll-like receptor 4, PTX3 pentraxin-3
  2. aPatient works as a farmer, mason, carpenter/construction, or has outdoor work with likely spore exposures
  3. bHigh-risk malignancy defined as diagnosis of acute myeloid leukemia or allogeneic HSCT
  4. cUncontrolled malignancy defined as malignancy status that is not in partial or complete remission
  5. dHigh-risk chemotherapy was defined as chemotherapy for AML and conditioning chemotherapy for allogeneic HSCT