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Table 1 Characteristics of patients

From: Genetic Risk Surveillance for Invasive Aspergillosis in Hematology Patients: A Prospective Observational Study

Characteristics Patients, n = 357 (%) No IA, n = 321 (%) IA, n = 36 (%) IA rate, % value
Median age (IQR) 57.0 (44.0–64.0) 57.0 (46.0–65.0) 43.5 (32.5–58.0) 0.001
Age, years       < 0.001
 < 40 77 (21.6) 60 (18.7) 17 (47.2) 22.1  
 41–60 147 (41.2) 135 (42.1) 12 (33.3) 8.1  
 > 60 133 (37.3) 126 (39.3) 7 (19.4) 5.3  
Male gender 188 (52.7) 172 (53.6) 16 (44.4) 8.5 (male), 11.8 (female) 0.298
Underlying hematologic disease       < 0.001
 Allogeneic HSCT 21 (5.9) 19 (5.9) 2 (5.6) 9.5  
 Acute myeloid leukemia 60 (16.8) 40 (12.5) 20 (55.6) 33.3  
 Acute lymphoblastic leukemia 28 (7.8) 24 (7.5) 4 (11.1) 14.3  
 Chronic lymphocytic leukemia 9 (2.5) 8 (2.5) 1 (2.8) 11.1  
 Non-Hodgkin’s lymphoma 161 (45.1) 156 (48.6) 5 (13.9) 3.1  
 Myelodysplastic syndrome 13 (3.6) 12 (3.7) 1 (2.8) 7.7  
 Severe aplastic anemia 4 (1.1) 3 (0.9) 1 (2.8) 25.0  
 Multiple myeloma 60 (16.8) 59 (18.4) 1 (2.8) 1.7  
 Severe GVHD after HSCT 1 (0.3) 0 (0) 1 (2.8) 100.0  
Other underlying disease
 Diabetes mellitus 28 (14.8) 26 (17.0) 2 (5.6) 7.1 0.082
 HIV 8 (2.3) 8 (2.5) 0 (0) 0 1.000
  1. IA invasive aspergillosis, IQR interquartile range, HSCT hematopoietic stem cell transplant, GVHD graft versus host disease