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Table 1 clinical features

From: The Treatment of Hypersalivation in Rett Syndrome with Botulinum Toxin: Efficacy and Clinical Implications

Patient Age (years) Age at onset (months) Oral habit HRIM Onset gastrointestinal problems Pneumonia ab ingestis/respiratory infection Dysphagia score Respiratory dysfunction Posture abnormalities/severe scoliosis Rehabilitation Epilepsy AEDs
1 19 18 Bruxism 3 6 years (reflux) Yes 2 Apnea Yes No
2 23 16 Bruxism 2 10 years (vomiting) Yes 2 Oral breathing Yes Yes LTG, CBZ, VPA
3 21 20 Bruxism, stereotyped tongue movements 2 5 years (reflux) Yes 2 Hyperventilation Yes Yes PB
4 13 22 Bruxism 3 10 (reflux) No 1 Apnea, hyperventilation Yes Yes No
5 16 13 bruxism 2 10 years (dysphagia) Yes 2 Hyperventilation Yes Yes VPA, CLB
  1. HRIM hands repetitive involuntary movement (1: none; 2 mild; 3: severe), Dysphagia score (1: normal; 2: mild; 3: moderate; 4: severe), AEDs anti-epileptic drugs, LTG lamotrigine, CBZ carbamazepine, VPA valproic acid, PB phenobarbital, CLB clobazam