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Table 2 Dose of methadone and electrocardiographic variables before and after treatment

From: Effect of Methadone on Cardiac Repolarization in Japanese Cancer Patients: A Longitudinal Study

 Baseline1 week1 month2 months
Mean dose of methadone (mg)020 ± 736 ± 1353 ± 23
 QT in II (ms)349 ± 46356 ± 32390 ± 44379 ± 50
 QT in V5 (ms)338 ± 49348 ± 35361 ± 62365 ± 52
 QTc in II (ms)392 ± 31408 ± 39410 ± 40425 ± 42
 QTc in V5 (ms)393 ± 42399 ± 34411 ± 37412 ± 27
 QTD (ms)58 ± 1777 ± 2872 ± 3682 ± 29
 QTcD (ms)69 ± 2388 ± 3394 ± 4097 ± 41
 TpTe in II (ms)82 ± 1784 ± 1098 ± 17106 ± 20*
 TpTe in V5 (ms)80 ± 1683 ± 1292 ± 16107 ± 18*
 TpTe/QT in II0.24 ± 0.070.23 ± 0.030.25 ± 0.060.25 ± 0.06
 TpTe/QT in V50.24 ± 0.060.24 ± 0.040.24 ± 0.040.26 ± 0.04
 TpTe/QTc in II0.20 ± 0.040.2 ± 0.030.22 ± 0.060.21 ± 0.04
 TpTe/QTc in V50.20 ± 0.030.21 ± 0.020.21 ± 0.030.23 ± 0.02
  1. Data are presented as means ± standard deviations
  2. QTD QT dispersion, QTcD QTc dispersion, TpTe T peak-T end
  3. *p < 0.05 versus baseline value