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Nanoscale metal–organic frameworks as smart nanocarriers for cancer therapy

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Abstract

Cancer is one of the serious diseases to human life. Early and precise cancer diagnosis and timely therapy are in urgent need nowadays. Due to the advantages of porous structures and tunable properties, metal–organic frameworks (MOFs) are becoming type of rapidly developing and attractive supports used in biomedicine, which have been widely applied in the fields of chemistry, biology, materials science, etc. Particularly, nanoscale MOFs (nMOFs) with more accessible active sites and improved stability are ideal platforms for biological and clinical applications in vitro and in vivo. This review article summarizes the recent progresses in nMOFs based nanoplatforms for drug delivery and cancer therapy. Different techniques using nMOFs are systematically summarized including chemotherapy, photodynamic therapy (PDT), photothermal therapy (PTT), chemodynamic therapy (CDT), radiotherapy (RT), and the combined therapy methods. Finally, a brief conclusion and outlook for biomedical applications of this special field is provided. We expect this review could be helpful for future designing and fabrication of multi-functional nMOFs platforms for drug delivery, disease therapy, and other biomedical applications.

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  • 16 June 2022

    The original version of this article was revised to update the email id of the authors.

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Acknowledgements

This work was supported by grants from the National Natural Science Foundation of China (22022412, 21874155, 22104060), the Natural Science Foundation of Jiangsu Province (BK20200716, BK20191316), the Natural Science Foundation of the Jiangsu Higher Education Institutions of China (20KJB150019), Innovation and Entrepreneurship Doctor Program of Jiangsu Province (JSSCBS20210317), the State Key Laboratory of Analytical Chemistry for Life Science (SKLACLS2106), and the Qing-Lan Project of Jiangsu Province (2019).

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  1. School of Environment, Nanjing Normal University, Nanjing, 210023, China

    Yang Liu

  2. Analytical and Testing Center, Nanjing Normal University, Nanjing, 210023, China

    Xuewei Liao

  3. College of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China

    Chen Wang

  4. Department of Orthopedic Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China

    Pengfei Lei

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Liu, Y., Lei, P., Liao, X. et al. Nanoscale metal–organic frameworks as smart nanocarriers for cancer therapy. J Nanostruct Chem 14, 1–19 (2024). https://doi.org/10.1007/s40097-022-00493-2

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