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Synthesis and characterization of Au and Bi2O3 decorated Fe3O4@PAMAM dendrimer nanocomposites for medical applications

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Abstract

Fe3O4 magnetic nanoparticles were produced and covered with TEOS and APTES which were known to reduce the toxic properties of nanoparticles. Nanoparticles were functionalized second-generation PAMAM dendrimers and doped with Au and Bi2O3 nanoparticles where Fe3O4@G2/Au/Bi2O3 nanocomposites were obtained for potential multimodal imaging applications. Physicals structures of the nanocomposites were characterized using SEM and TEM which illustrate that nanoparticles were in composite form. Chemical composition of nanostructures was confirmed using EDX and FTIR. Magnetic characteristics were checked using VSM. It was seen that nanoparticles have superparamagnetic properties which indicate that nanocomposites have potential to be used in MRI and magnetic hyperthermia applications. X-ray imaging properties were confirmed using X-ray imaging and CT imaging. It was confirmed that doping nanoparticles with Au and Bi2O3 nanoparticles significantly enhanced the X-ray tomography contrast enhancement properties which illustrate the theranostic properties of the nanocomposites.

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Acknowledgements

This work was supported by Duzce University Scientific Research Project Commission with project number 2019.07.06.981. We also would like to thank Mr. Gökhan AYDEĞER for his valuable contributions.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Arts and Sciences, Kırklareli University, Kırklareli, Turkey

    Nurdan Kurnaz Yetim & Fatma Kurşun Baysak

  2. School of Medical Service, Kırklareli University, Kırklareli, Turkey

    Mümin Mehmet Koç

  3. Department of Polymer Engineering, Faculty of Technology, Düzce University, Düzce, Turkey

    Dilek Nartop

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  1. Nurdan Kurnaz Yetim
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Correspondence to Nurdan Kurnaz Yetim.

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Kurnaz Yetim, N., Kurşun Baysak, F., Koç, M.M. et al. Synthesis and characterization of Au and Bi2O3 decorated Fe3O4@PAMAM dendrimer nanocomposites for medical applications. J Nanostruct Chem 11, 589–599 (2021). https://doi.org/10.1007/s40097-021-00386-w

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