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Experimental verification of isocenter calibration for image-guided radiosurgery system using predictive modeling

  • Original Paper - Cross-Disciplinary Physics and Related Areas of Science and Technology
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Abstract

The use of image-guided radiotherapy (IGRT)/radiosurgery (IGRS) is inevitable for high-precision radiation treatment. This study aimed to predict the contribution of off-axis distance (OAD) factors in vertical (Z), longitudinal (Y), and lateral (X) directions calculated through experimental verification and distance criteria for the pass/fail rating of isocenter calibration. Experimental verification (n = 104) for periodic isocenter calibration between IGRS and linear accelerator (LINAC) was performed using a cube water slab phantom and radiochromic film. The dataset was used to develop a predictive model, basic statistical analysis was performed. In this first radiochromic analysis, the mean and standard deviations were calculated to be OAD (X) 0.43 ± 0.17 mm, OAD (Y) 0.42 ± 0.16 mm, and OAD (Z) 0.47 ± 0.15 mm for 104 experimental cases. In predictive modeling, feature importance analysis on X, Y, and Z revealed that OAD (Z), 0.066 (mean SHAP) was a remarkable factor in determining the passing rate for calibration. The probability of distinguishing the threshold distance for OAD (X, Y, and Z) was also calculated, and the performance metrics of the predictive model were calculated as 0.86 accuracy, 0.94 sensitivity, 0.61 specificity, and 0.84 AUC. Experimental verification of an IGRS system based on an optical camera by applying the predictive modeling technique confirmed that the significant prediction factor was the Z axis for the isocenter calibration of the LINAC and IGRT systems. The error was calculated at a threshold of under 0.5 mm between coordinates in the radiosurgery room.

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Authors and Affiliations

  1. Department of Neurosurgery, Inje University Ilsan Paik Hospital, College of Medicine, Goyang, 10380, Korea

    Kwang Hyeon Kim, Byung-Jou Lee & Hae-Won Koo

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  1. Kwang Hyeon Kim
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  2. Byung-Jou Lee
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Contributions

KHK: performed the experiment and analyzed the data including curation and consolidation. KHK: developed the analysis software and performed the analysis including predictive modeling. HK: contributed to the interpretation of the results for the basic statistical analysis. HK: supervised the project. KHK: wrote the manuscript. HK: contributed to the interpretation of the results and contributed to the final version of the manuscript. BL: provided critical feedback and helped shape the research, analysis, and manuscript.

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Correspondence to Hae-Won Koo.

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Kim, K.H., Lee, BJ. & Koo, HW. Experimental verification of isocenter calibration for image-guided radiosurgery system using predictive modeling. J. Korean Phys. Soc. 82, 1222–1230 (2023). https://doi.org/10.1007/s40042-023-00779-w

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  • DOI: https://doi.org/10.1007/s40042-023-00779-w

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