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Phytochemistry, Nociceptive, Fertility and Microbicidal Potential of Secamone afzelii in Animal Models and Microbes

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Proceedings of the National Academy of Sciences, India Section B: Biological Sciences Aims and scope Submit manuscript

Abstract

Folklore reports established on Secamone afzelii aid in the management of several diseases including infertility, nociceptive, infection, diabetes and many more. This study evaluates the phytochemical screening, anti-nociceptive, fertility and microbicide effect of S. afzelii. Standard procedure was used for the phytochemistry, nociceptive, fertility and antimicrobial activities. The phytochemical present includes; flavonoids, phenol, tannins, glycoside and terpenoids. A significant increase in percentage inhibition of peripheral and central pain of acetic acid and hot plate induced pain in mice (p < 0.05). The hormonal indexes elicited a significant increase in testosterone level at graded doses (30, 50 and 100 mg/kg) of (4.37; 3.15; 3.26 pg/ml) and also stimulate other female hormones when compared with the control (p > 0.05). A significant increase in total sperm count (376.67, 256.67 and 330.00 count), progressive mobility (56.67, 73.33 and 73.33 count), and decreased in non-progressive mobility (13.33, 13.33 and 13.33 count), and immobility (30.00, 13.33 and 13.33 count) in the test groups when compared with control. The histopathological study showed no deterioration in the treated testes. The antimicrobial activity elicited an inhibitory effect against gram positive and negative microbes of the extract (p > 0.05). This study validated S. afzelii traditional uses in the management of diseases.

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Acknowledgements

Our intense appreciation goes to Mr. Kelvin Odega of the Department of Morbid Anatomy, University of Benin Teaching Hospital, and Dr. Agu for the antioxidant study in the Department of Medical Biochemistry, University of Benin.

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Authors and Affiliations

  1. Phytomedicine Unit, Department of Plant Biology and Biotechnology, University of Benin, PMB 1154, Benin, Edo State, Nigeria

    Idu MacDonald, Chukwudi N. Lazarus, Odaro Timothy & Gabriel O. Benjamin

  2. Department of Science Laboratory Technology, Faculty of Life Sciences, University of Benin, PMB 1154, Benin, Edo State, Nigeria

    Gabriel O. Benjamin

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  1. Idu MacDonald
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Correspondence to Gabriel O. Benjamin.

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MacDonald, I., Lazarus, C.N., Timothy, O. et al. Phytochemistry, Nociceptive, Fertility and Microbicidal Potential of Secamone afzelii in Animal Models and Microbes. Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci. 94, 31–39 (2024). https://doi.org/10.1007/s40011-023-01503-1

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