Probiotics for the Abrogation Arsenic Toxicity: A review

Abstract

Arsenic toxicity, principally by polluted groundwater, is regarded as a momentous global public health risk, as there is no particular and proven treatment for chronic arsenic toxicity, i.e. arsenicosis. Probiotics include the live apathogenic microorganisms, which are administered orally to revamp the gut microbial equilibrium thus bestowing benefit to the host. Scientific literature demonstrates different probiotic microorganisms can obviate arsenic toxicity. The present article puts together the experiments on probiotics with arsenic toxicity alleviation effects in pursuit of the mechanistic hypotheses. Literature scrutiny was performed by using online bibliographic databases. Literature haunt exhibited that there are four kinds of probiotic microorganisms that afforded significant abrogation from arsenic toxicity in experimental pre-clinical works. Clinical investigation with noteworthy outcome was not reported yet. Results of these studies indicate that probiotics may hold the promise in amelioration and therapeutics of arsenic toxicity and the prime mechanisms are found to be their antioxidant and anti-inflammatory effects. Probiotic supplementation may serve as a dietary therapeutic approach against arsenicosis along with extant therapies.