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In Vitro and In Vivo Study of Argyreia speciosa on Chronic Gastric Ulceration and Metabolic Studies

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Proceedings of the National Academy of Sciences, India Section B: Biological Sciences Aims and scope Submit manuscript

Abstract

Chronic gastric ulcer being the most prevalent gastrointestinal disorder is considered a major cause of gastric cancer. Large numbers of synthetic drugs ranging from proton-pump inhibitors and H2 receptor antagonist to cytoprotective agents are available, but they have major side effects. Inadequacy of these synthetic drugs forces to develop new herbal-based drugs active against chronic gastric ulcer. In the present study, antiulcer activity of butanolic extract of Argyreia speciosa Linn. f., Sweet: Family Convolvulaceae (b-ASL) was investigated against acetic-acid-induced chronic gastric ulcer rat models. The effect of different dose of butanolic extract of A. speciosa was studied for antioxidant, anti-secretory, and cytoprotective activities. Extract administration significantly increased the gastric PGE2 content. The further experiments including the in vitro metabolic stability and in vivo pharmacokinetics gave a clear indication that butanolic extract of A. speciosa (200 mg/kg) is an orally active and safe contender of antiulcer agents. It can be an important target for further studies under chronic ulcer management system.

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Acknowledgements

The authors are thankful to the Director, CSIR-National Botanical Research Institute, Lucknow, India for providing necessary facilities. They are grateful to Department of Science and Technology (DST), Ministry of Science and Technology, New Delhi, India, for providing DST-INSPIRE fellowship.

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Authors and Affiliations

  1. Pharmacognosy and Ethnopharmacology Division, CSIR-National Botanical Research Institute, Lucknow, India

    Lubna Azmi, Ila Shukla, Shyam Sundar Gupta & Ch. V. Rao

  2. Department of Chemistry, University of Lucknow, Lucknow, India

    Lubna Azmi & Padam Kant

  3. CSIR-Central Institute of Medicinal and Aromatic Plants (CIMAP), Lucknow, India

    Narayan Prasad Yadav

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  1. Lubna Azmi
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  2. Ila Shukla
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  6. Ch. V. Rao
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Correspondence to Ch. V. Rao.

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Significance statement

Argyreia speciosa significantly increased the gastric PGE2 content against ulcer. In vitro metabolic stability and in vivo pharmacokinetics gave a clear indication that A. speciosa is an orally active and safe contender of antiulcer agents.

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Azmi, L., Shukla, I., Gupta, S.S. et al. In Vitro and In Vivo Study of Argyreia speciosa on Chronic Gastric Ulceration and Metabolic Studies. Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci. 89, 1039–1045 (2019). https://doi.org/10.1007/s40011-018-1023-8

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  • DOI: https://doi.org/10.1007/s40011-018-1023-8

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