Efficacy Assessment of Celecoxib Oil Drops Versus Arachidonic Acid Stimulated Ophthalmic Inflammation in Rabbits
- 27 Downloads
The most comfortable approach to deliver an active pharmaceutical ingredient to the eye has been via topical instillation of aqueous drops. However, the aqueous drops suffer a major setback due to the rapid drainage leading to loss of drug. The aim of the present work was to formulate oil preparations of celecoxib in different oils. Partition behavior, trans-corneal permeation, viscosity, in vivo anti-inflammatory study and gamma scintigraphy of the preparations were investigated. Incorporation of benzyl alcohol resulted in a significant increase in drug permeation across the cornea (p < 0.05). The in vivo efficacy of optimized castor oil formulation was found to be better than control as well as CXB-aqueous suspensions in arachidonic acid triggered eye swelling model in rabbits. Further, results of gamma scintigraphy also indicated prolonged retention. Therefore, the oil eye drops may be a promising alternative, to aqueous eye drops circumventing poor retention in management of ocular ailments.
KeywordsOil drops Trans-corneal permeation Arachidonic acid Protein estimation Gamma scintigraphy
The acknowledgements are owed to Director, INMAS, Delhi for authorization to accomplish gamma scintigraphy experimentation. The authors are indebted for assistance offered by technical personnel and Dr. Ejan of Nuclear Medicine Department, INMAS, Delhi.
Compliance with Ethical Standards
Conflict of interest
There is no conflict of interest among authors for publishing this manuscript.
- 10.Hecht G, Roehrs RE, Cooper ER, Hiddemen JW, VanDuzee BF (1990) Design and evaluation of ophthalmic pharmaceutical products. In: Banker GS, Rhodes CT (eds) Modern pharmaceutics, vol 40, 2nd edn. Marcel Dekker, New York, pp 539–603Google Scholar
- 14.Sood R (1999) Medical laboratory technology: methods and interpretations. Jaypee Brothers, New Delhi, pp 169–177Google Scholar
- 19.Longer MA, Robinson JR (1990) In: Gennaro AR (ed) Remington’s pharmaceutical sciences, 18th edn. Mack Publishing Company, Easton, p 1687Google Scholar