Abstract
The basic attribute that differentiates animals and plants apart from their established biological differences and photosynthesis is that the former tend to escape from vagaries of nature to protect themselves “physically” whereas the latter being immobile (anchored in soil) have the only choice to face the adversities on their stride, “chemically”. In philosophical terms this also teaches us a biological strategy that the best way to face challenges in life is to face, respond with activity (metabolic) and cope with them so as to turn them into capabilities (biological functions). The plants have acquired this capability by evolving in such a way through phytomolecules through a flexible functional metabolome that caters to their ever-changing demands for survival and existence. The best models to study the functional diversity of plant metabolomes are the non-model medicinal and aromatic plants. This paper discusses functional diversity of plant metabolomes vis-à-vis their utility for mankind in tangible terms through illustrative case studies. Humans (~100 trillion cells) on the other hand are merely 10 % of their own in terms of genome or metabolome being dependent on 90 % of the cells that are in and on them of the microflora that determines human health and performance through a unique colonization and balance of populations in the gut or GI tract.
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Shasany AK, Shukla AK, Khanuja SPS (2007) Medicinal and aromatic plants. In: Kole C (ed) Genome mapping and molecular breeding in plants, vol 6: technical crops. Springer, Berlin, pp 175–196
Khanuja SPS, Tripta Jhang, Shasany AK (2010) Medicinal and aromatic plants: A case example of evolving secondary metabolome and metabolic pathway diversity. In: Sharma VP (ed) Nature at work–ongoing saga of evolution. National Academy of Sciences, India, Springer, New Delhi, pp 355–358
Khanuja SPS, Shukla AK (2011) Human health and nutrition: functional foods. In: Chadha KL, Singh AK, Patel VB (eds) Horticulture to horti-business, souvenir of the fourth Indian horticulture congress held at New Delhi during 18–21 November, 2010. Westville, New Delhi, pp 433–445
Khanuja SPS (2002) Plant metabolomics: the path through pathways. J Med Aromat Plant Sci 24(3):663
Darokar MP, Mathur A, Dwivedi S, Bhalla R, Khanuja SPS, Kumar S (1998) Detection of antibacterial activity in the floral petals of some higher plants. Curr Sci 75:187–189
Bagchi GD, Singh A, Khanuja SPS, Bansal RP, Singh SC, Kumar S (1999) Wide spectrum antibacterial and antifungal activities in the seeds of some coprophilous plants of north Indian plains. J Ethnopharmocol 64:69–77
Kumar S, Bagchi GD, Darokar MP (1997) Antibacterial activity observed in the seeds of some coprophilous plants. Int J Pharmacogn 35:179–184
Khanuja SPS, Darokar MP, Mishra S, Gangwar A, Shasany AK, Kumar TRS, Saikia D, Kumar S (2001) Development of a novel plant system as biosensor for detecting environmental hazards and bioactive molecules through distinct responses. J Environ Pathol Toxicol Oncol 20:15–22
Shukla YN, Srivastava A, Kumar TRS, Khanuja SPS, Kumar S (2000) Antibacterial activity of Oenothera biennis and one of its constituent. Indian Drugs 37:60–61
Shukla YN, Srivastava A, Kumar TRS, Khanuja SPS, Kumar S (2001) Antibacterial constituents of Bixa orellana seeds. Indian Drugs 38:338–339
Baldwin WS, LeBlanc GA (1992) The anti-carcinogenic plant compound indole-3-carbinol differentially modulates P450-mediated steroid hydroxylase activities in mice. Chem Biol Interact 83:155–169
Wattenberg LW (1975) Effects of dietary constituents on the metabolism of chemical carcinogens. Cancer Res 35:3326–3331
Qinghaosu Antimalarial Coordinating Group (1979) Antimalarial studies on qinghaosu. Chin Med J 98:811–816
Wani MC, Taylor HL, Wall ME, Coggon P, McPhail AT (1971) Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. J Am Chem Soc 93:2325–2327
Arya JS (2003) In vitro screening of phytochemicals for improving bioefficacy of antibiotics. PhD thesis. Department of Biotechnology, Barkatullah University, Bhopal, India
Svoboda GH (1961) Alkaloids of Vinca rosea (Catharanthus roseus) 1X: extraction and characterization of leurosidine and leurocristine. Lloydia 24:173–178
Noble RL, Beer CT, Cutts JH (1958) Role of chance observation in chemotherapy: vinca rosea. Ann N Y Acad Sci 76:882
Johnson IS, Wright HF, Svoboda GH (1959) Experimental basis for clinical evaluation of anti-tumor principles from Vinca rosea Linn. J Lab Clin Med 54:830
Svoboda GH (1958) A note on several new alkaloids from Vinca rosea Linn. 1: leurosine, virosine, perivine. J Am Pharm Assoc, Sci Ed 47:834
Svoboda GH, Neuss N, Gorman M (1959) Alkaloids of Vinca rosea Linn. (Catharanthus roseus G. Don.) V. Preparation and characterization of alkaloids. J Am Pharm Assoc, Sci Ed 48:659–666
Wall ME, Wani MC, Cook CE, Palmer KH, McPhail AT, Sim GA (1966) Plant antitumor agents. 1. The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from Camptotheca acuminata. J Am Chem Soc 88:3888–3890
Kuttan R, Bhanumathy P, Nirmala K, George MC (1985) Potential anticancer activity of turmeric (Curcuma longa). Cancer Lett 29:197–202
Min JK, Han KY, Kim EC, Kim YM, Lee SW, Kim OH, Kim KW, Gho YS, Kwon YG (2004) Capsaicin inhibits in vitro and in vivo angiogenesis. Cancer Res 64:644–651
McQueen EG, Doyle AE, Smirk FH (1954) Mechanism of hypotensive action of reserpine, an alkaloid of Rauwolfia serpentina. Nature 174:1015
Meier R, Bein HJ, Gross F, Tripod J, Tuchmann-Duplessis H (1954) Hypotensive effect of reserpine, a new Rauwolfia serpentina Benth., on animal. C R Hebd Seances Acad Sci 238:527–528
Lorence A, Nessler CL (2004) Molecules of interest camptothecin, over four decades of surprising findings. Phytochemistry 65:2735–2749
Shukla AK, Shasany AK, Gupta MM, Khanuja SPS (2006) Transcriptome analysis in Catharanthus roseus leaves and roots for comparative terpenoid indole alkaloid profiles. J Exp Bot 57:3921–3932
Sellitto M, Bai G, Serena G, Fricke WF, Sturgeon C, Gajer P, White JR, Koenig SS, Sakamoto J, Boothe D, Gicquelais R, Kryszak D, Puppa E, Catassi C, Ravel J, Fasano A (2012) Proof of concept of microbiome-metabolome analysis and delayed gluten exposure on celiac disease autoimmunity in genetically at-risk infants. PLoS ONE 7(3):e33387
Cho I, Blaser MJ (2012) The human microbiome: at the interface of health and disease. Nat Rev Genet 13(4):260–270
Acknowledgments
Sincere thanks to my student & colleague Dr. Ashutosh Shukla who is presently Senior Scientist at CIMAP/CSIR for enabling the content of the manuscript. The base information emanating from CSIR/CIMAP and NutraHelix Biotech knowledge banks in this paper is duly acknowledged.
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Khanuja, S.P.S. Functional Diversity of Plant Metabolome and Microbiome in Health Services to the Human Life. Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci. 82 (Suppl 2), 291–294 (2012). https://doi.org/10.1007/s40011-012-0105-2
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DOI: https://doi.org/10.1007/s40011-012-0105-2