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On 3D Printing of Architected PLA-PLA Nanofiber-Based Biomedical Scaffolds

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Abstract

Architected scaffolds are being used extensively in tissue engineering applications. Some studies have reported the architected structures of polylactic acid (PLA) nanofibers (NF), prepared by fused filament fabrication (FFF)-based 3D printing. But hitherto little has been reported on the mechanical properties of PLA-PLA (NF)-PLA-based scaffolds. In this study, the PLA(NF) were electrospun in the first stage, and an architected scaffold of PLA-PLA(NF) (with 1, 2, and 3 layers)-PLA was prepared in the second stage. Further, the fracture morphology of the architected scaffolds was investigated from the crash-loading viewpoint. The PLA-PLA(2NF)-PLA scaffold resulted in an improved modulus of toughness (MoT) (5.62%) as compared to PLA. However, a significant drop in the elastic modulus (E) was observed. The maximum surface roughness (Ra: 204.50 nm) was observed at the fracture region of the PLA-PLA(3NF)-PLA scaffold. The results have been supported by scanning electron microscopy (SEM) and Fourier-transform infrared spectroscopy (FTIR) analysis.

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Acknowledgements

The authors acknowledge the research support provided by the National Institute of Technical Teachers Training and Research, Chandigarh (India), and Chandigarh University, Mohali (India).

Funding

The authors are thankful to the Science and Engineering Research Board for funding under TAR/2021/000126.

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Authors and Affiliations

  1. University Center for Research and Development, Chandigarh University, Mohali, India

    Ranvijay Kumar

  2. Department of Mechanical Engineering, National Institute of Technical Teachers Training and Research, Chandigarh, India

    Ranvijay Kumar & Rupinder Singh

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  1. Ranvijay Kumar
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  2. Rupinder Singh
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Correspondence to Rupinder Singh.

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Kumar, R., Singh, R. On 3D Printing of Architected PLA-PLA Nanofiber-Based Biomedical Scaffolds. Natl. Acad. Sci. Lett. 46, 391–395 (2023). https://doi.org/10.1007/s40009-023-01261-8

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  • DOI: https://doi.org/10.1007/s40009-023-01261-8

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