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Recent progresses in the development of hyaluronic acid-based nanosystems for tumor-targeted drug delivery and cancer imaging

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Abstract

Background

Hyaluronic acid (HA) has been widely used as one of major components of nanocarriers for cancer imaging and therapy. HA possesses hydrophilic and anionic properties at physiological pH and its molecular weight can affect the physicochemical and mechanical behaviors. HA or HA derivatives can be processed into the nanocarriers with other functional materials, drug cargos, and imaging agents by several preparation methods. Moreover, its biocompatibility and biodegradability can increase its feasibility for clinical application.

Area covered

Physicochemical and biological properties of HA are summarized in this review. Based on those properties, various types of HA nanosystems can be designed for CD44 receptor-positive cancer imaging and therapy. Recent progresses in HA-drug conjugates, HA-based nanoparticles (NPs), and HA-decorated NPs for cancer imaging and therapy are provided.

Expert opinion

Together with well-known biocompatibility/biodegradability and CD44 receptor-positive tumor targetability, expandability in chemical modification of HA and fabrication of HA-based nanosystems may elevate their possibility of clinical application.

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Acknowledgements

This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning and the Ministry of Education (Nos. 2017R1E1A1A01074584 and 2018R1A6A1A03025582).

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  1. College of Pharmacy, Kangwon National University, Chuncheon, Gangwon, 24341, Republic of Korea

    Hyun-Jong Cho

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Cho, HJ. Recent progresses in the development of hyaluronic acid-based nanosystems for tumor-targeted drug delivery and cancer imaging. J. Pharm. Investig. 50, 115–129 (2020). https://doi.org/10.1007/s40005-019-00448-w

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