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Design, fabrication and characterization of xanthan gum/liquid-loaded porous natural rubber film

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Abstract

Porous natural rubber (NR) films were prepared with blocked natural rubber by solvent casting method using dichloromethane as the solvent. The various amount of xanthan gum (0–40 phr) was blended in 75 phr triethyl citrate or glycerin-loaded NR cast films. Xanthan gum markedly promoted the water sorption of these composite films. The proper compatibility of the component employed in these composite NR films was confirmed by X-ray diffractometry, thermogravimetry and differential scanning calorimetry. Although the porosity of composite NR films decreased when xanthan gum was added xanthan gum amount did not significantly affect the mechanical properties, wettability and degradability. The 20 phr xanthan gum was selected as the optimum amount to modify the liquid-loaded NR films for further as wound dressing.

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Acknowledgements

This research work was kindly supported by the Thailand Research Fund (Grant No. RDG5650126). The authors would like to thank the Faculty of Pharmacy, Silpakorn University, Nakhon Pathom and the Faculty of Pharmaceutical Sciences, Prince of Songkla University, Songkhla, Thailand for their facilities and support.

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Authors and Affiliations

  1. Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, 73000, Thailand

    Thawatchai Phaechamud, Nutdanai Lertsuphotvanit, Pongsathorn Issarayungyuen & Takron Chantadee

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  1. Thawatchai Phaechamud
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  2. Nutdanai Lertsuphotvanit
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  3. Pongsathorn Issarayungyuen
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  4. Takron Chantadee
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Correspondence to Thawatchai Phaechamud.

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Phaechamud, T., Lertsuphotvanit, N., Issarayungyuen, P. et al. Design, fabrication and characterization of xanthan gum/liquid-loaded porous natural rubber film. J. Pharm. Investig. 49, 149–160 (2019). https://doi.org/10.1007/s40005-018-0396-2

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  • DOI: https://doi.org/10.1007/s40005-018-0396-2

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