Novel and effectual delivery of an antifungal agent for the treatment of persistent vulvovaginal candidiasis
- 42 Downloads
The main objective of the present work was to develop and evaluate a mucoadhesive in-situ based gel for the vaginal delivery of Fluconazole (FLZ). The formulation was developed using the cold method and evaluated for various physicodynamic and aesthetic properties. The gelling agents used were evaluated for their potential to gel FLZ without affecting its structure. The bioadhesive potential and antifungal activity of the FLZ in-situ gel was determined in comparison to the marketed antifungal topical cream, FLUCOS®. The drug content varied from 95.3 to 98.01% and pH values were found to be slightly acidic (4.2–4.5), as normal for the vaginal milieu. The FLZ in-situ gel showed significantly higher in-vitro bioadhesion of 0.277 and antifungal activity as compared to the marketed formulation with a bioadhesion of 0.281, and did not show any signs of vaginal irritation. Thus, it can be concluded that the developed intravaginal in-situ gel formulation can be used for effective targeted treatment of vulvovaginal candidiasis (VVC) in comparison to FLUCOS® with better mucoadhesion, drug release, permeability and drug retention characteristics with more acceptable patient compliance.
KeywordsMucoadhesive In-situ gel Fluconazole Vaginal drug delivery Vulvovaginal candidiasis
The authors are thankful to University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh for their skillfull assistance and for providing study facility in this study. Authors would like to acknowledge Microbiology Department, Panjab University, Chandigarh for their support rendered during this project.
Compliance with ethical standards
Conflict of interest
The authors declare no conflict of interest regarding publication of this paper.
- Ibrahim ESA, Ismail S et al (2012) Development and characterization of thermosensitive pluronic-based metronidazole in-situ gelling formulations for vaginal application. Acta Pharm Sci 62:59–70Google Scholar
- Kant A, Reddy S et al (2011) In situ gelling system—an overview. Pharmacol Online 2:28–44Google Scholar
- Majid Z, Ali ZM (2009) Invasive candidiasis; a review article. Jundishapur J Microbiol 2009(1, Winter):1–6Google Scholar
- Patil PR, Shaikh SS et al (2014) In-situ gel: a novel drug delivery system. Indo Am J Pharm Res 4(11):5406–5414Google Scholar
- Rendo-Lopez V, Lynch M et al (1990) Torulopsis glabrata vaginitis: clinical aspects and susceptibility to antifungal agents. Obstetr Gynecol 76(4):651–655Google Scholar
- Sakthivel M, Kannan K et al (2012) Formulation and in vitro evaluation of niosomes containing oxcarbazepine. Int J Pharm Sci 4:563–567Google Scholar
- Tett S, Moore S et al (1995) Pharmacokinetics and bioavailability of fluconazole in two groups of males with human immunodeficiency virus (HIV) infection compared with those in a group of males without HIV infection. Antimicrob Agents Chemother 39(8):1835–1841CrossRefPubMedPubMedCentralGoogle Scholar
- Woolfson AD, Malcolm RK et al (2000) Drug delivery by the intravaginal route. Crit Rev Therap Drug Carrier Syst 17:509–555Google Scholar