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Effects of combination therapy with candesartan and ramipril on hypertension and related complications

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Abstract

Hypertension is a major risk factor for cardiovascular diseases and is known to contribute to complications, such as atherosclerosis and diabetes. The aim of this study was to investigate the possible synergistic effects of candesartan, an angiotensin II receptor blocker (ARB), and ramipril, an angiotensin-converting enzyme inhibitor (ACEI), in lowering high blood pressure in spontaneously hypertensive rats (SHRs). SHRs were given oral candesartan (1.53 mg/kg/day) and ramipril (0.48 mg/kg/day) for 2 weeks. The combination of candesartan and ramipril improved systolic blood pressure (SBP), mean arterial pressure (MAP), and heart rate (HR) significantly compared with monotherapy. Additionally, combined treatment with candesartan (3.06 mg/kg/day) and ramipril (0.96 mg/kg/day) significantly decreased cuff-induced neointima hyperplasia and media thickness in C57BL/6 mice. In oral glucose tolerance tests (OGTTs), the combination of candesartan and ramipril significantly controlled blood glucose levels within 2 h after glucose loading in low-dose (38 mg/kg, i.p.) streptozotocin-treated Wistar rats. Taken together, the present study suggests that combination therapy with candesartan and ramipril may be a beneficial therapeutic strategy for the treatment of hypertensive patients with related complications, such as atherosclerosis and diabetes.

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Acknowledgements

None of the authors (D. H. Lee, E. J. Jo, E. J. Ga, J. H. Han, S. H. Jung, H. S. Park, K. S. Heo, or C. S. Myung) has any potential conflicts of interest. The study was supported financially by the research fund of Chungnam National University (2015).

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Authors and Affiliations

  1. Department of Pharmacology, Chungnam National University College of Pharmacy, Daehak-ro 99, Yuseong-gu, Daejeon, 34134, Republic of Korea

    Do-Hyung Lee, Eun Ji Jo, Eun-Ji Ga, Joo-Hui Han, Sang-Hyuk Jung, Hyun-Soo Park, Kyung-Sun Heo & Chang-Seon Myung

  2. Institute of Drug Research & Development, Chungnam National University, Daejeon, 34134, Republic of Korea

    Chang-Seon Myung

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  1. Do-Hyung Lee
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  2. Eun Ji Jo
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Correspondence to Chang-Seon Myung.

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All experimental procedures were performed in accordance with the Guide for the National Institutes of Health Guide for the Care and Use of Laboratory Animals as approved by Chungnam National University Animal Care and Use Committee.

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Lee, DH., Jo, E.J., Ga, EJ. et al. Effects of combination therapy with candesartan and ramipril on hypertension and related complications. Journal of Pharmaceutical Investigation 47, 365–371 (2017). https://doi.org/10.1007/s40005-017-0339-3

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  • DOI: https://doi.org/10.1007/s40005-017-0339-3

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