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Probiotic delivery systems: a brief overview

Journal of Pharmaceutical Investigation volume 46, pages 377–386 (2016)Cite this article

Abstract

Over the past decades, the administration of probiotic bacteria as nutraceuticals has gained much attention. Probiotics are live microorganisms which confer a health benefit on the host when administered in an adequate amount. The health benefits of probiotics are dependent on the viability and sufficient number of probiotics in the target intestine. Due to probiotic’s vulnerability to several environmental factors such as temperature and pH, maintaining the viability of probiotics has long been a hurdle to develop successful probiotic delivery systems. In this review, we provide an overview of health benefits of probiotics, hurdles in probiotic delivery, commonly used encapsulating materials and recent probiotic delivery technologies.

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Acknowledgments

This work was supported by a 2-Year Research Grant of Pusan National University. All authors (J. Kim, N. Muhammad, B.H. Jhun and J.-W. Yoo) declare that they have no conflict of interest.

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    Authors and Affiliations

    1. College of Pharmacy, Pusan National University, Busan, South Korea

      Jihyun Kim, Naeem Muhammad & Jin-Wook Yoo

    2. College of Nanoscience & Nanotechnology, Pusan National University, Busan, South Korea

      Jihyun Kim & Byung Hak Jhun

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    1. Jihyun Kim
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    Correspondence to Jin-Wook Yoo.

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    Jihyun Kim and Naeem Muhammad contributed equally to this work.

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    Kim, J., Muhammad, N., Jhun, B.H. et al. Probiotic delivery systems: a brief overview. Journal of Pharmaceutical Investigation 46, 377–386 (2016). https://doi.org/10.1007/s40005-016-0259-7

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    Keywords

    • Probiotic delivery
    • Microencapsulation
    • Acid-resistance
    • Thermo-tolerance