Abstract
A selective and simple HPLC method was developed for ibuprofen (IBF) and pamabrom (PAMB) from in bulk and drug product using the same conditions, which was operated on a reverse phase (C18 column) with water (60 %) and acetonitrile (40 %.) solutions at a flow rate of 1.0 mL/min. IBF was detected at 2.6 min and PAMB at 8.0 min, respectively at 254 nm. The correlation coefficient (R 2) for IBF was 0.9999 and that of PAMB was 0.9998 in 125–2000 and 63–100 μg/mL, respectively. Intraday precision showed less than 1.0 % RSD. This method was validated in an aspect of linearity, precision, accuracy, limit of detection and limit of quantitation. This method was suggested to analysis the fixed dose combination tablet of IBF and PAMB.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Girolamo GD, Sánchez AJ, De Los Santos AR, González CD (2004) Is acetaminophen, and its combination with pamabrom, an effective therapeutic option in primary dysmenorrhoea? Expert Opin Pharmacother 5:561–570
ICH-Q2B (1996) Validation of analytical procedures: methodology international conference on harmonization of technical requirements for registration of pharmaceuticals for human use, Geneva
Martindale: the extra pharmacopoeia (1996). The Royal Pharmaceutical Society of Great Britain, London
McCarthy MD (2012) Efficacy and gastrointestinal risk of aspirin used for the treatment of pain and cold. Best Pract Res Clin Gastroenterol 26:101–112
Moghbel A, Abbaspour H (2013) Study of compressibility properties of yogurt powder in order to prepare a complementary formulation. Iran J Pharm Res. 12:231–237
Ortiz MI, Fernández-Martínez E, Pérez-Hernández N, Macías A, Rangel-Flores E, Ponce-Monter H (2007) Patterns of prescription and self-medication for treating primary dysmenorrhea in a Mexican population. Proc West Pharmacol Soc 50:165–167
Padaliya H, Patel H (2013) Development and validation pf RP-HPLC method for simultaneous estimation of paracetamol and pamabrom in bulk and pharmaceutical dosage form. Int J Univ Pharm BioSci 2:129–140
Palma SD, Manzo RH, Allemandi DA (1999) Dry plant extracts loaded on fumed silica for direct compression: preparation and preformulation. Pharm Dev Technol 4:523–530
Premal P, Anamdkumari DC and Dankil SP (2013). International Research Journal of Pharmacy. (http://www.irjponline.com). Accessed 10 May 2013
Acknowledgments
This article does not contain any studies with human and animal subjects performed by any of the authors. All authors (H.S. Jun, J.S. Kang, J.S. Park, C.W. Cho) declare that they have no conflict of interest. This study was financially supported by the Priority Research Centers Program (2009-0093815) through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Jun, HS., Kang, JS., Park, JS. et al. Simultaneous analysis of ibuprofen and pamabrom by HPLC. Journal of Pharmaceutical Investigation 45, 555–560 (2015). https://doi.org/10.1007/s40005-015-0203-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s40005-015-0203-2