Journal of Pharmaceutical Investigation

, Volume 45, Issue 1, pp 65–71 | Cite as

Synthesis, analgesic and anti-inflammatory activities of novel mannich bases of benzimidazoles

  • Neeraj KumarEmail author
  • C. S. Sharma
  • M. S. Ranawat
  • H. P. Singh
  • L. S. Chauhan
  • N. Dashora
Research Article


A series of novel mannich bases of 2-substituted benzimidazoles was synthesized by the reaction of 2-substituted benzimidazoles with corresponding aldehyde and acetophenones. The structures of all synthesized compounds were confirmed by elemental analysis, IR, 1H-NMR, 13C-NMR and LCMS. The compounds were evaluated for in vivo analgesic and in vivo anti-inflammatory activities by a tail flick method and carrageenan-induced rat paw edema test respectively. Among all the compounds synthesized, compound A1 and B3 exhibited significant analgesic and anti-inflammatory activities. Acute ulcerogenicity studies showed that compound A1 and B3 were devoid of gastrointestinal toxicities.


Benzimidazole Mannich base Anti-inflammatory Analgesic Ulcerogenicity 



This article does not contain any studies with human and animal subjects performed by any of the authors. All authors (N. Kumar, C.S. Sharma, M.S. Rarawat, H.P. Singh, L.S. Chauhan, and N. Dashora) declare that they have no conflict of interest. The authors deeply appreciate the assistance of the Department of Pharmacology, B N College of Pharmacy, Udaipur in the pharmacological screening of the compounds. The authors also deeply appreciate the Punjab University, Punjab, India for providing the spectral studies.


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Copyright information

© The Korean Society of Pharmaceutical Sciences and Technology 2014

Authors and Affiliations

  • Neeraj Kumar
    • 1
    Email author
  • C. S. Sharma
    • 2
  • M. S. Ranawat
    • 2
  • H. P. Singh
    • 2
  • L. S. Chauhan
    • 3
  • N. Dashora
    • 1
  1. 1.Geetanjali Institute of PharmacyUdaipurIndia
  2. 2.Department of Pharmaceutical ChemistryB. N. College of PharmacyUdaipurIndia
  3. 3.Department of Pharmaceutical SciencesMohanlal Sukhadia UniversityUdaipurIndia

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