Abstract
The objective of present work was to develop a “tablets in capsule” system for facilitating both immediate and pulsatile drug deliveries of theophylline to mimic the circadian rhythm of nocturnal asthma. The system comprised of capsule filled with two tablets, first pulse and second pulse tablet prepared by wet granulation method. First pulse tablet was not coated and was responsible for providing loading dose whereas; second pulse tablet was coated with Eudragit L100 and Eudragit S100 to release drug in colon after specific lag time. Two independent variables, amount of polymers and coating thickness, were optimized by 32 full factorial design. The optimum formulation consisted of Eudragit L100: Eudragit S100 in 1:1.5 ratio and coating thickness of 20 % (w/w). In vitro drug release of “tablets in capsule” system in three different media (pH 1.2, pH 6.8, and pH 7.4) revealed immediate and pulsatile release patterns.
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Acknowledgments
This article dose not contain any studies with human and animal subjects performed by any of the authors. All authors (S. Pandey, P. Mehta, H. Patel, R. Shah, A. Gupta, and A. Mishra) declare that they have no conflict of interest. The authors wish to acknowledge Sidmak Pharmaceuticals, Valsad, India for providing theophylline as gift sample and Dr. Renu Chauhan for sparing her valuable time for correcting language and grammatical errors of the manuscript.
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Pandey, S., Mehta, P., Patel, H. et al. Novel time and site specific “tablets in capsule” system for nocturnal asthma treatment. Journal of Pharmaceutical Investigation 44, 381–390 (2014). https://doi.org/10.1007/s40005-014-0133-4
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DOI: https://doi.org/10.1007/s40005-014-0133-4