Journal of Pharmaceutical Investigation

, Volume 43, Issue 4, pp 343–351 | Cite as

Quick dissolving films of nebivolol hydrochloride: formulation and optimization by a simplex lattice design

  • Punit B. Parejiya
  • Rakshit C. Patel
  • Dharmik M. Mehta
  • Pragna K. Shelat
  • Bhavesh S. BarotEmail author
Research Article


Present study aims at formulation and development of quick dissolving film of nebivolol hydrochloride applying simple lattice experimental design using three hetero polymers hydroxypropyl methylcellulose, pullulan and polyvinyl pyrrolidone. Films were prepared using solvent casting technique and optimized formulation was derived by desirability function. Regression equations and contour plots were executed to narrate dependent variables, i.e. percentage drug release in 30 s (Y30), tensile strength, elastic modulus, percentage elongation and load at yield, to independent variables. Results of the experimental design revealed that the independent factors hydroxypropyl methylcellulose and pullulan significantly influenced the mechanical properties and percentage drug release from the film which was ultimately reflect in the formulation of optimized batch. The high % drug release of the film in simulated saliva and simulated gastric fluid indicated that it can be successfully used in drug delivery systems for drugs with high first-pass metabolism.


Desirability function Nebivolol hydrochloride Quick dissolving films Similarity factor Simplex lattice design 


Conflict of interest



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Copyright information

© The Korean Society of Pharmaceutical Sciences and Technology 2013

Authors and Affiliations

  • Punit B. Parejiya
    • 1
  • Rakshit C. Patel
    • 1
  • Dharmik M. Mehta
    • 1
  • Pragna K. Shelat
    • 1
  • Bhavesh S. Barot
    • 1
    Email author
  1. 1.Department of PharmaceuticsK. B. Institute of Pharmaceutical Education and ResearchGandhinagarIndia

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