Abstract
Levofloxacin-loaded nanofibrous scaffolds from chitosan (CS) and poly(ε-caprolactone) (PCL) were prepared using coaxial electrospinning for the controlled release of antibiotics. Levofloxacin was encapsulated in the CS phase as a core and PCL was employed to control the release of levofloxacin as a shell. The levofloxacin-loaded nanofibrous scaffolds prepared at different PCL concentrations (8, 12, 16, and 20 wt%) were characterized by SEM and TEM to confirm their surface morphology and core-shell structure. The nanofibrous scaffold prepared at a higher PCL concentration exhibited higher mechanical properties. In addition, the CS–PCL nanofibrous scaffold exhibited more sustained release of levofloxacin than PCL nanofibrous scaffolds prepared using both single and coaxial nozzles. This levofloxacin-loaded nanofibrous scaffold can potentially be employed for the sustained release of antibiotics after surgical operations.
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Acknowledgements
This study was financially supported by a Korea Science and Engineering Foundation (KOSEF) grant funded by the Korean Government (MOST) (No. R11-2007-050-00000-0 and R01-2007-000-10353-0), the Nano R&D Program through the Korea Science and Engineering Foundation funded by the Ministry of Education, Science, and Technology (2011-0019176), the Ministry of Knowledge Economy (10030051), the Korea Science and Engineering Foundation (2010-0029220, 2009K001644), Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2011-0023064), a grant of the Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (A110416), and a grant from the “GRRC” Project of Gyeonggi Provincial Government, Korea.
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Park, H., Yoo, H., Hwang, T. et al. Fabrication of levofloxacin-loaded nanofibrous scaffolds using coaxial electrospinning. Journal of Pharmaceutical Investigation 42, 89–93 (2012). https://doi.org/10.1007/s40005-012-0014-7
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DOI: https://doi.org/10.1007/s40005-012-0014-7