Beneficial Effects of Garlic in Livestock and Poultry Nutrition: A Review

Abstract

The ban on the use of synthetic antibiotics in feed by the European Union has pushed animal nutritionists to use natural alternatives as growth promoters, such as prebiotics, probiotics, organic acids, herbs and several others. Garlic (Allium sativum), one of such natural alternative growth promoters, is used globally as a spice in human food preparation. Garlic belongs to the genus Allium and family Liliaceae and is grown in tropical and subtropical countries. Studies have revealed that garlic is a rich source of essential nutrients and beneficial phytochemicals that can be incorporated in animal feed to enhance gut activity and promote growth in livestock and poultry. Research abounds that indicates that garlic phytochemicals have antibacterial, antifungal, hypocholesterolemic and antioxidant effect in animals. This review intends to showcase the importance of adding garlic in livestock and poultry nutrition, so as to promote its use in animal nutrition as an alternative phytochemical source for better growth, health and production performance. The use of garlic in feed as replacement of antibiotics will reduce antimicrobial resistance and ensure safe, organic and healthy food for humans.

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References

  1. 1.

    Abd El-Hack M, Alagawany M, Farag M, Tiwari R, Karthik K, Dhama K, Zorriehzahra J, Adel M (2016) Beneficial impacts of thymol essential oil on health and production of animals, fish and poultry: a review. J Essent Oil Res 28:365–382

    Article  CAS  Google Scholar 

  2. 2.

    Adewumi MK (2008) Complementary effects of raw garlic and water-washed Neem fruit on in vitro gas production characteristics and blood chemistry of West African dwarf sheep. Trop Anim Prod Invest 11:7–12

    Google Scholar 

  3. 3.

    Ahmad K, Alireza V, Mohsen DM, Reza V (2011) The effect of garlic oil (Allium sativa), turmeric powder (Curcuma longa Linn) and monensin on total apparent digestibility of nutrients in Baloochi lambs. World Acad Sci Eng Technol Int J Anim Vet Sci 5:791–793

    Google Scholar 

  4. 4.

    Aji SB, Ignatius K, Ado AY, Nuhu JB, Abdulkarim A (2011) Effect of feeding onion (Allium cepa) and garlic (Allium sativum) on some performance characteristics of broiler chickens. Res J Poult Sci 4:22–27

    Google Scholar 

  5. 5.

    Akgul B, Lin K, Yang HO, Chen Y, Lu T, Chen C, Kikuchi T, Chen Y, Tu CD (2010) Garlic accelerates red blood cell turnover and splenic erythropoietic gene expression in mice: evidence for erythropoietin-independent erythropoiesis. PLoS ONE 5:e15358. https://doi.org/10.1371/journal.pone.0015358

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  6. 6.

    Alagawany M, Ali Ashour E, Reda FM (2016) Effect of dietary supplementation of garlic (Allium sativum) and turmeric (Curcuma longa) on growth performance, carcass traits, blood profile and oxidative status in growing rabbit. Ann Anim Sci 16:489–505

    Article  CAS  Google Scholar 

  7. 7.

    Al-Shuwaili MA, Ibrahim EI, Naqi Al-Bayati MT (2015) Effect of dietary herbal plants supplement in turkey diet on performance and some blood biochemical parameters. Glob J Biosci Biotechnol 4(2):153–157

    Google Scholar 

  8. 8.

    Amagase H (2006) Clarifying the real bioactive constituents of garlic. J Nutr 136:716S–725S

    Article  CAS  PubMed  Google Scholar 

  9. 9.

    Anassori E, Dalir-Naghadeh B, Pirmohammedi R, Hadian M (2014) Changes in blood profile in sheep receiving raw garlic oil or monensin. J Anim Physiol Anim Nutr 99:114–122

    Article  CAS  Google Scholar 

  10. 10.

    Anvar A, Behrouz D, Jalil GN, Kyung IS, Jayant L, Fereidoun F (2012) Effects of garlic and thyme extracts on growth performance and carcass characteristics of broiler chicks. J Anim Sci Technol 54:185–190

    Article  CAS  Google Scholar 

  11. 11.

    Ashayerizadeh O, Daster B, Shargh MS (2009) Use of garlic (Allium cepa), black cumin seeds and wild mint (Mentha longifolia) in broiler chicken diets. J Anim Vet Adv 8:1860–1863

    Google Scholar 

  12. 12.

    Bampidis VA, Christodoulou V, Christaki E, Florou-Paneri P, Spais AB (2005) Effect of dietary garlic bulb and garlic husk supplementation on performance and carcass characteristics of growing lambs. Anim Feed Sci Technol 121:273–283

    Article  Google Scholar 

  13. 13.

    Barreto MSR, Menton JFM, Racanicci AMC, Pereira PWZ (2008) Plant extract used as growth promoters in broilers. Braz J Poult Sci 10:109–115

    Article  Google Scholar 

  14. 14.

    Bedford MR, Cowieson AJ (2012) Exogenous enzymes and their effects on intestinal microbiology. Anim Feed Sci Technol 173:76–85

    Article  CAS  Google Scholar 

  15. 15.

    Benchaar C, Petit HV, Berthiaume R, Ouellet DR, Chiquette J, Chouinard PY (2007) Effects of essential oils on digestion, ruminal fermentation, rumen microbial populations, milk production, and milk composition in dairy cows fed alfalfa silage or corn silage. J Dairy Sci 90:886–889

    Article  CAS  PubMed  Google Scholar 

  16. 16.

    Borazjanizadeh M, Eslami M, Bojarpour M, Chaji M, Fayazi J (2011) The effect of clove and oregano on economic value of broiler chickens diet under hot weather of Khuzesta. J Anim Vet Adv 10:169–173

    Article  CAS  Google Scholar 

  17. 17.

    Busquet M, Calsamiglia S, Ferret A, Carro MD, Kamel C (2005) Effect of garlic oil and four of its compounds on rumen microbial fermentation. J Dairy Sci 88:4393–4404

    Article  CAS  PubMed  Google Scholar 

  18. 18.

    Busquet M, Calsamiglia S, Ferret A, Carro MD, Kamel C (2005) Effects of cinnamaldehyde and garlic oil on rumen microbial fermentation in a dual flow continuous culture. J Dairy Sci 88:2508–2516

    Article  CAS  PubMed  Google Scholar 

  19. 19.

    Busquet M, Calsamiglia S, Ferret A, Kamel C (2006) Plant extracts affect in vitro rumen microbial fermentation. J Dairy Sci 89:761–771

    Article  CAS  PubMed  Google Scholar 

  20. 20.

    Canoglulari S, Baylan M, Erdogan Z, Duzguner V, Kucukgul A (2010) The effect of dietary garlic powder on performance, egg yolk and serum cholesterol concentrations in laying quails. Czech J Anim Sci 55:286–293

    Article  Google Scholar 

  21. 21.

    Castillejos L, Calsamiglia S, Ferret A (2006) Effect of essential oil active compounds on rumen microbial fermentation and nutrient flow in vitro systems. J Dairy Sci 89:2649–2658

    Article  CAS  PubMed  Google Scholar 

  22. 22.

    Charron CS, Dawson HD, Novotny JA (2016) Garlic influences gene expression in vivo and in vitro. J Nutr 146:444S–449S

    Article  CAS  PubMed  Google Scholar 

  23. 23.

    Chaves A, Stanford K, Dugan M, Gibson L, Mcallister T, Van Herk F, Benchaar C (2008) Effects of cinnamaldehyde, garlic and juniper berry essential oils on rumen fermentation, blood metabolites, growth performance, and carcass characteristics of growing lambs. Livest Sci 117:215–224

    Article  Google Scholar 

  24. 24.

    Chen YJ, Kim IH, Cho JH, Yoo JS, Wang Q, Wang Y, Huang Y (2008) Evaluation of dietary L-carnitine or garlic powder on growth performance, dry matter and nitrogen digestibility, blood profiles and meat quality in finishing pigs. Anim Feed Sci Technol 141:141–152

    Article  CAS  Google Scholar 

  25. 25.

    Chen C, Pung D, Leong V, Hebbar V, Shen G, Nair S, Li W, Kong A-NT (2004) Induction of detoxifying enzymes by garlic organosulfur compounds through transcription factor Nrf2: effect of chemical structure and stress signals. Free Radic Biol Med 37:1578–1590

    Article  CAS  PubMed  Google Scholar 

  26. 26.

    Choi IH, Park WY, Kim YJ (2010) Effects of dietary garlic powder and α-tocopherol supplementation on performance, serum cholesterol levels, and meat quality of chicken. Poult Sci 89:1724–1731

    Article  CAS  PubMed  Google Scholar 

  27. 27.

    Chu GM, Lee HH, Park JS, Cho HW, Ahn BH (2003) Effect of garlic stalk silage on performance and carcass characteristics of Hanwoo steers. J Anim Sci Technol 45:1007–1018

    Article  CAS  Google Scholar 

  28. 28.

    Chun SM, Kim SC, Joo ST, Yang HS (2015) Effect of dietary garlic-husk probiotics on laying hens performance and egg quality. J Agric Life Sci 49:137–146

    Article  Google Scholar 

  29. 29.

    Corrigan BP, Wolter BF, Ellis M, Moreland S (2001) Effect of three dietary growth promoting additives on performance of nursery pigs. J Anim Sci 79:1885 Abstract

    Google Scholar 

  30. 30.

    Cullen SP, Monahan FJ, Callan JJ, O’D ohertyty JV (2005) The effect of dietary garlic and rosemary on grower-finisher pig performance and sensory characteristics of pork. Irish J Agric Food Res 44:57–67

    CAS  Google Scholar 

  31. 31.

    Czech A, Kowalczuk E, Grela ER (2009) The effect of a herbal extract used in pig fattening on the animals’ performance and blood components. Ann UMCS-EE 27:25–33

    Google Scholar 

  32. 32.

    Dehari H, Tchaikkovskaya T, Rubashevsky E, Sellers R, Listowsky I (2009) The proximal promoters governs germ cell-specific expression of the mouse glutathione transferase mGstm5 gene. Mol Reprod Dev 76:379–388

    Article  CAS  Google Scholar 

  33. 33.

    DeLange CFM, Pluske JR, Gong J, NyachotI CM (2010) Strategic use of feed ingredients and feed additives to stimulate gut health and development in young pigs. Livest Sci 134:124–134

    Article  Google Scholar 

  34. 34.

    Dhama K, Latheef SK, Mani S, Samad HA, Kartik K, Tiwari R, Khan RU, Al-agawany M, Farag MR, Alam GM, Laudadio V, Tufarelli V (2015) Multiple beneficial applications and modes of action of herbs in poultry health and production—a review. Int J Pharmacol 11:152–176

    Article  CAS  Google Scholar 

  35. 35.

    El-Barbary MI (2018) Impact of garlic and curcumin on the hepatic histology and cytochrome P450 gene expression of aflatoxicosis Oreochromis niloticus using RT-PCR. Turk J Fishery Aquat Sci 18:405–415

    Google Scholar 

  36. 36.

    El-Bayoumy K, Sinha R, Pinto JT, Rivlin RS (2006) Cancer chemoprevention by garlic and garlic containing sulphur and selenium compounds. J Nutr 136:864S–869S

    Article  CAS  Google Scholar 

  37. 37.

    Eid KM, Iraqi MM (2014) Effect of garlic powder on growth performance and immune response for Newcastle and Avian influenza virus diseases in broiler of chickens. Anim Biotech (Poult Fish) 7:7–15

    Google Scholar 

  38. 38.

    El-Gogary MR, Mansour AM, El-Said EA (2018) Blood biochemical and immunological responses to garlic oil administration in growing rabbits’ diet. J Agric Sci 10:217–224

    Google Scholar 

  39. 39.

    El-Khtam AO, El-Latif AA, El-Hewaity MH (2014) Efficiency of turmeric (Curcuma longa) and garlic (Allium sativum) on Eimeria species in broilers. Int J Basic Appl Sci 3:349–356

    CAS  Google Scholar 

  40. 40.

    Eligib HAA, El-Amin WIA, Elamin KM, Malik HEE (2013) Effect of garlic (Allium sativum) supplementation as feed additive on broiler performance and blood profile. J Anim Sci Adv 3:58–64

    Article  CAS  Google Scholar 

  41. 41.

    Fadlalla IMT, Mohammed BH, Bakhiet AO (2010) Effect of feeding garlic on the performance and immunity of broilers. Asian J Poult Sci 4:182–189

    Article  CAS  Google Scholar 

  42. 42.

    Gerzilov V, Nikolov A, Petrov P, Bozakova N, Penchev G, Bochukov A (2015) Effect of a dietary herbal mixture supplement on the growth performance, egg production and health status in chickens. J Cent Eur Agric 16:10–27

    Article  Google Scholar 

  43. 43.

    Ghalehkandi JG (2014) Garlic (Allium sativum) juice protects from semen oxidative stress in male rats exposed to chromium chloride. Anim Reprod 11:526–532

    Google Scholar 

  44. 44.

    Ghosh S, Mehla R, Sirohi S, Tomar S (2011) Performance of crossbred calves with dietary supplementation of garlic extract. J Anim Physiol Anim Nutr 95:449–455

    Article  CAS  Google Scholar 

  45. 45.

    Ghosh S, Mehla RK, Sirohi S, Roy B (2010) The effect of dietary garlic supplementation on body weight gain, feed intake, feed conversion efficiency, faecal score, faecal coliform count and feeding cost in crossbred dairy calves. Trop Anim Health Prod 42:961–968

    Article  Google Scholar 

  46. 46.

    Gibson GR, Probert HM, Loo JV, Rastall RA, Roberfroid MB (2004) Dietary modulation of the human colonic microbiota: updating the concept of prebiotics. Nutr Res Rev 17:259–275

    Article  CAS  Google Scholar 

  47. 47.

    Gong J, Yin F, Hou Y, Yin Y (2014) Chinese herbs as alternatives to antibiotics in feed for swine and poultry production: Potential and challenges in application. Can J Anim Sci 94:223–241

    Article  Google Scholar 

  48. 48.

    Gracı´a-Gonza´ lez R, Lo´ pez M, Bodas RF, Gonza´ lez JS (2007) Screening the activity of plants and spices for decreasing ruminal methane production in vitro. Anim Feed Sci Technol 147:36–52

    Article  CAS  Google Scholar 

  49. 49.

    Grela RR, Klebaniuk R (2007) Chemical composition of garlic preparation and its utilization in piglet diets. Med Weter 63:792–795

    Google Scholar 

  50. 50.

    Grela ER, Pietrzak K, Sobolewska S, Witkowski P (2013) Effect of inulin and garlic supplementation in pig diets. Ann Anim Sci 13:63–71

    Article  Google Scholar 

  51. 51.

    Hafiz ARS, Masood SB, Nauman K, Saira S, Ali R, Muhammad A, Munawar A (2015) Garlic (Allium sativum) diet based therapy of 21st century—a review. Asian Pac J Trop Dis 5:271–278

    Article  CAS  Google Scholar 

  52. 52.

    Ham JS, Lee SG, Kim MK, Oh MH, Jeong SG, Kim DH et al (2010) Inhibitory activity of garlic fermented by Pediococcus pentosaceus KACC 91419 against antibiotic-resistant pathogens. Asian Australas J Anim Sci 23:1236–1243

    Article  CAS  Google Scholar 

  53. 53.

    Hanieh H, Narabara K, Piao M, Gerile C, Abe A, Kondo Y (2010) Modulatory effects of two levels of dietary Allium sativum on immune responses and certain immunological variables following immunization in White leghorn chickens. Anim Sci J 81:673–680

    Article  CAS  Google Scholar 

  54. 54.

    Hashemipour H, Kermanshahi H, Golian A, Veldkamp T (2013) Effect of thymol and carvacrol feed supplementation on performance, antioxidant enzyme activities, fatty acid composition, digestive enzyme activities, and immune response in broiler chickens. Poult Sci 92:2059–2069

    Article  CAS  Google Scholar 

  55. 55.

    Hassan EH, Abdel-Raheem SM (2013) Response of growing buffalo calves to dietary supplementation of caraway and garlic as natural additives. World Appl Sci J 22:408–414

    CAS  Google Scholar 

  56. 56.

    Holden PJ, McKean JD (2002) Botanicals for nursery pigs. J Anim Sci 80:41 Abstract

    Google Scholar 

  57. 57.

    Holden PJ, McKean JD, Franzenburg E (2001) Botanicals as part of an integrated value-added pork production system. In: Leopold Center progress report, Vol 10. Iowa State University, USA

  58. 58.

    Horev-Azaria L, Eliav S, Izigov N, Pri-Chen S, Mirelman D, Miron T, Rabinkov A, Wilchek M, Jacob-Hirsch J, Amariglio N et al (2009) Allicin up-regulates cellular glutathione level in vascular endothelial cells. Eur J Nutr 48:67–74

    Article  CAS  Google Scholar 

  59. 59.

    Hosoda K, Matsuyama H, Park WY, Nishida T, Ishida M (2006) Supplementary effect of peppermint on dry matter intake, digestibility, ruminal fermentation and milk production in early lactating dairy cows. Anim Sci J 77:503–509

    Article  CAS  Google Scholar 

  60. 60.

    Hossian J, Kamruzzaman M, Akbar A, Haque A (2015) Feeding garlic powder on growth performance, nutrient digestibility and carcass characteristics of rabbit. Int J Nat Soc Sci 2:74–81

    Google Scholar 

  61. 61.

    Ikyume TT, Sowande OS, Dele PA, Yusuf AO, Monday S, Egunjobi OK, Fatoba O (2007) Effect of varying levels of garlic (Allium sativum) powder on growth, apparent nutrient digestibility, rumen ecology, blood profile and cost analysis of feeding West African Dwarf goats. Malays J Anim Sci 20:61–74

    Google Scholar 

  62. 62.

    Incharoen T, Yamauchi K, Thongwittaya N (2010) Intestinal villus histological alterations in broilers fed dietary dried fermented ginger. J Anim Physiol Anim Nutr (Berl) 94:130–137

    Article  CAS  Google Scholar 

  63. 63.

    Indrasanti D, Indradji M, Hastuti S, Aprilliyani E, Rosyadi KA (2017) The administration of garlic extract on Eimeria stiedai oocysts and the hematological profile of the coccidia infected rabbits. Media Peternak 40:158–164

    Article  Google Scholar 

  64. 64.

    Issa KJ, Omar JMA (2012) Effect of garlic powder on performance and lipid profile of broilers. Open J Anim Sci 2:62–68

    Article  CAS  Google Scholar 

  65. 65.

    Jambrenghi AC, Colonna MA, Giannico F, Favia R, Minuti F, Scafizzari M, Vonghia G (2005) Dietary supplementation of garlic and rosemary: effects on colour stability and lipid oxidation in lamb meat. Ital J Anim Sci 4:366–368

    Article  Google Scholar 

  66. 66.

    Javandel F, Navidshad B, Seifdavati J, Pourrahimi GH, Baniyaghoub S (2008) The favorite dosage of garlic meal as a feed additive in broiler chickens ration. Pak J Biol Sci 11:1746–1749

    Article  CAS  PubMed  Google Scholar 

  67. 67.

    Javed M, Durrani F, Hafeez A, Khan RU, Ahmad I (2009) Effect of aqueous extract of plant mixture on carcass quality of broiler chicks. ARPN J Agric Biol Sci 4:37–40

    Google Scholar 

  68. 68.

    Kamel C, Greathead H (2008) Garlic and cinnamon for a healthy rumen. Feed Mix 15 nr. 4. http://www.allaboutfeed.net. Accessed Dec 2009

  69. 69.

    Kamel C, Greathead HMR, Ranilla MJ, Tejido ML, Ramos S, Carro MD (2009) Effects of garlic oil on in vitro rumen fermentation and methane production are influenced by the basal diet. Dairy Cattle. www.Engormix.com. Accessed 8 May 2018

  70. 70.

    Kamra DN, Agarwal N, Sakthivel PC, Chaudhary LC (2012) Garlic as a rumen modifier for eco-friendly and economic livestock production. J Appl Anim Res 40:90–96

    Article  CAS  Google Scholar 

  71. 71.

    Kamruzzaman M, Liang X, Sekiguchi N, Sano H (2014) Effect of feeding garlic leaf on microbial nitrogen supply, kinetics of plasma phenylalanine, tyrosine and protein synthesis in sheep. Anim Sci J 85:542–548

    Article  CAS  PubMed  Google Scholar 

  72. 72.

    Kamruzzaman M, Torita A, Sako Y, Al-Mamun M, Sano H (2011) Effects of feeding garlic stem and leaf silage on rates of plasma leucine turnover, whole-body protein synthesis and degradation in sheep. Small Rumin Res 99:37–43

    Article  Google Scholar 

  73. 73.

    Karangiya VK, Savsani HH, Patil SS, Garg DD, Murthy KS, Ribadiya NK, Vekariya SJ (2016) Effect of dietary supplementation of garlic, ginger and their combination on feed intake, growth performance, and economics in commercial broilers. Vet World 9:245–250

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  74. 74.

    Kemper KJ (2000) Garlic (Allium sativum) longwood herbal task force. http://www.mcp.edu/herbal/default.htm. Accessed 8 May 2018

  75. 75.

    Khan QSH, Hasan S, Sadar R, Anjum MA (2008) Effects of dietary garlic powder on cholesterol concentration in Native Desi laying hens. Am J Food Technol 21:207–213

    Article  Google Scholar 

  76. 76.

    Khan QSH, Sadar R, Anjum MA (2007) Effects of dietary garlic powder on performance and serum and egg yolk cholesterol concentration in laying hens. Asian Australas J Anim Sci 21:22–27

    Google Scholar 

  77. 77.

    Kholif SM, Morsy TA, Abdo MM (2012) Effect of supplementing lactating goat rations with garlic, cinnamon or ginger oils on milk yield, milk composition and milk fatty acids profile. J Life Sci 4:27–34

    Article  Google Scholar 

  78. 78.

    Kim SM, Kubota K, Kobayashi A (1997) Antioxidative activity of sulfur-containing flavor compounds in garlic. Biosci Biotechnol Biochem 61:1482–1485

    Article  CAS  Google Scholar 

  79. 79.

    Kim HP, Wang X, Zhang J, Suh GY, Benjamin IJ (2005) Heat shock protein-70 mediates the cytoprotective effect of carbon monoxide: involvement of p38beta MAPK and heat shock factor-1. J Immunol 175:2622–2629

    Article  CAS  PubMed  Google Scholar 

  80. 80.

    Kirkpinar F, Ünlü HB, Serdaroğlu M, Turp GY (2014) Effects of dietary oregano and garlic essential oils on carcass characteristics, meat composition, colour, pH and sensory quality of broiler meat. Brit Poult Sci 55:157–166

    Article  CAS  Google Scholar 

  81. 81.

    Konjufca VH, Pesti GM, Bakalli RI (1997) Modulation of cholesterol levels in broiler meat by dietary garlic and copper. Poult Sci 76:1264–1271

    Article  CAS  PubMed  Google Scholar 

  82. 82.

    Kumar S, Sharadmma KC, Radhakrishna L (2010) Effect of a garlic active based growth promoter on growth performance and specific pathogenic intestinal microbial counts of broiler chicks. Int J Poult Sci 9:244–246

    Article  CAS  Google Scholar 

  83. 83.

    Kwon OS, Cho JH, Min BJ, Kim HJ, Chen YJ, Yoo JS, Kim IH, La JC, Park HK (2005) Effect of supplemental medicinal plants (Artemisia, Acanthopanax and Garlic) on growth performance, IGF-1 and meat quality characteristics in growing-finishing pigs. Korean J Food Sci Anim Resour 25:316–321

    Google Scholar 

  84. 84.

    Lee YE, Kim YI, Oh YK, Ahmadi F, Kwak WS (2017) Yield survey and nutritional evaluation of garlic stalk for ruminant feed. J Anim Sci Technol 59:22. https://doi.org/10.1186/s40781-017-0147-3

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  85. 85.

    Lewis MR, Rose SP, Mackenzie AM, Tucker LA (2003) Effects of dietary inclusion of plant extracts on the growth performance of male broiler chickens. Brit Poult Sci 44:S43–S44

    Article  Google Scholar 

  86. 86.

    Lim KS, You SJ, An BK, Kang CW (2006) Effects of dietary garlic powder and copper on cholesterol content and quality characteristics of chicken eggs. Asian Australas J Anim Sci 19:582–586

    Article  CAS  Google Scholar 

  87. 87.

    Mohamed IE, Mosad AS, Mohamed MS, Adel Hasen H (2016) Growth performance, immune response, blood serum parameters, nutrient digestibility and carcass traits of broiler chicken as affected by dietary supplementation of garlic extract (Allicin). Alex J Vet Med 49:50–64

    Google Scholar 

  88. 88.

    Mahmoud KZ, Saad M, Gharaibeh H, Zakaria A, Amer M (2010) Garlic (Allium sativum) supplementation influence on egg production, quality and yolk cholesterol level in layer hens. Asian Australas J Anim Sci 23:1503–1509

    Article  CAS  Google Scholar 

  89. 89.

    Mahmoud S, Hassan MM, Alam M, Ahmad F (2009) Comparative efficacy of Nigella sativa and Allium sativum as growth promoters in broilers. Int J Agric Biol 11:775–778

    Google Scholar 

  90. 90.

    Mansoub NH (2011) Comparative Effects of using garlic as probiotic on performance and serum composition of broiler chickens. Ann Biol Res 2:486–490

    CAS  Google Scholar 

  91. 91.

    McAllister TA, Newbold CJ (2008) Redirecting rumen fermentation to reduce methanogenesis. Austr J Exp Agric 48:7–13

    Article  CAS  Google Scholar 

  92. 92.

    Milosevic N, Stanacev V, Peric L, Mirjana DS, Veljic M (2013) Effects of different levels of garlic powder in the diet on production parameters and slaughter traits of broiler chickens. Arch Geflügelk 77:254–259

    CAS  Google Scholar 

  93. 93.

    Miron T, Wilchek M, Sharp A, Nakagawa Y, Naoi M (2008) Allicin inhibits cell growth and induces apoptosis through mitochondrial pathway in HL60 and U937 cells. J Nutr Biochem 19:524–535

    Article  CAS  PubMed  Google Scholar 

  94. 94.

    Mohammed BMA, Kheravii SKQ (2011) Evaluation of genotoxic potential of Hypericum triquetrifolium extract in somatic and germ cells of male albino mice. Res Opin Anim Vet Sci 1:240–244

    Google Scholar 

  95. 95.

    Mottaghitalab M, Taraz Z (2002) Effects of garlic (Allium sativum) on egg yolk and blood serum cholesterol concentration in Aryan breed laying hens. Brit Poult Sci 43:S42–S43

    Article  Google Scholar 

  96. 96.

    Myung SC, Enusook TK, Stewart TJ (1982) Effects of garlic on lipid metabolism in rats fed cholesterol or lard. J Nutr 112:241–248

    Article  Google Scholar 

  97. 97.

    Navidshad B, Maghsoodi Z, Nikbin S, Vahedi V, Adibmoradi M, Aghjehgheshlagh FM, Moradi H (2018) The compensation effect of dietary garlic on chicken consuming a minimal level of choline. Ital J Anim Sci 17:175–179

    Article  CAS  Google Scholar 

  98. 98.

    Njamul K (2015) Effect of garlic and ginger supplementation on growth performance of broiler rabbit. M.Sc., Animal and Poultry Nutrition, Chittagong Veterinary and Animal Sciences University Khulshi, Chittagong-4225, Bangladesh, pp 1–64

  99. 99.

    Nosal P, Kowalska D, Bielański P, Kowal J, Kornaś S (2014) Herbal formulations as feed additives in the course of rabbit subclinical coccidiosis. Ann Parasitol 60:65–69

    PubMed  Google Scholar 

  100. 100.

    Ogbuewu IP, Nwogu CM, Iwuji TC (2017) Meta-analysis of the efficacy of yeast in improving milk production in lactating dairy cows. In: Proceedings of the 42nd annual conference on Nigeria Society for Animal Production (NSAP) held at Multipurpose Hall, Landmark University, Omu-Aran, Kwara State Nigeria, March 26–30, 2017, pp 72–75

  101. 101.

    Ogbuewu IP, Emenalom OO, Okoli IC, Iloeje MU (2018b) Meta-analysis of the effect of ginger (Zingiber officinale) on semen quality characteristics of breeder cocks. In: Proceedings of the 43rd annual conference on Nigeria Society for Animal Production held at New SAAT Lecture Theatre, Federal University of Technology Owerri, Imo State Nigeria, March 18–22, 2018, pp 159–162

  102. 102.

    Ogbuewu IP, Etuk IF, Odoemelam VU, Okoli IC, Iloeje MU (2014) Semen quality characteristics of post-pubertal rabbit bucks fed ginger rhizome meal based diets. Trop Anim Prod Invest 17:19–22

    Google Scholar 

  103. 103.

    Ogbuewu IP, Iwuji TC, Etuk IF, Ezeokeke CT, Okoli IC, Iloeje MU (2014) Responses of pubertal rabbits to dietary supplementation of ginger rhizome powder. Niger J Anim Prod 41:53–60

    Google Scholar 

  104. 104.

    Ogbuewu IP, Jiwuba PC, Ezeokeke CT, Uchegbu MC, Okoli IC, Iloeje MU (2014) Evaluation of phytochemical and nutritional composition of ginger rhizome powder. Int J Agric Rural Dev 17:1663–1670

    Google Scholar 

  105. 105.

    Ogbuewu IP, Kadurumba OE, Okoli IC, Iloeje MU (2013) Effect of ginger rhizome powder supplement and sex on haematological indices of pre-pubertal rabbits. J Agric Technol 9:11–19

    CAS  Google Scholar 

  106. 106.

    Ogbuewu IP, Mbajiorgu CA, Okoli IC (2017) Antioxidant activity of ginger and its effect on blood chemistry and production physiology of poultry. Comp Clin Pathol. https://doi.org/10.1007/s00580-017-2536-x

    Article  Google Scholar 

  107. 107.

    Ogbuewu IP, Nwaele A, Iwuji TC, Iwuji TC (2018a) Effect of onions-ginger mix supplementation on sperm motility of local breeder cocks. In: Proceedings of the 43rd annual conference on Nigeria Society for Animal Production held at New SAAT Lecture Theatre, Federal University of Technology Owerri, Imo State Nigeria, March 18–22 2018, pp 130–133

  108. 108.

    Ogbuewu IP, Okehi MC, Jiwuba PC (2017) Effect of phytobiotic (turmeric) supplementation on semen and blood characteristics of rabbits. Comp Clin Pathol. https://doi.org/10.1007/s00580-017-2452-0

    Article  Google Scholar 

  109. 109.

    Ogbuewu IP, Okoli IC, Iloeje MU (2013) The detrimental effect of dietary ginger rhizome powder supplementation on reproductive performance of pubertal rabbit bucks. Int J Innov Appl Stud 4:129–132

    Google Scholar 

  110. 110.

    Okoro VMO, Nwokeocha ACC, Ijezie CO, Mbajiorgu CA, Mbajiorgu EF (2016) Effect of varying dietary supplemental inclusion levels of onion and garlic on semen quality characteristics of Hubbard white breeder broiler cocks aged 35-41 weeks old. Indian J Anim Res 50:922–929

    Google Scholar 

  111. 111.

    Oleforuh-Okoleh VU, Chukwu GC, Adeolu AI (2014) Effect of ground ginger and garlic on the growth per-formance, carcass quality and economics of production of broiler chickens. Glob J Biosci Biotechnol 3:225–229

    Google Scholar 

  112. 112.

    Oleforuh-Okoleh VU, Ndofor-Foleng HM, Olorunleke SO, Uguru JO (2015) Evaluation of growth performance, haematological and serum biochemical response of broiler chickens to aqueous extract of ginger and garlic. J Agric Sci 7:167–176

    Google Scholar 

  113. 113.

    Omojola AB, Fagbuaro SS, Ayeni AA (2009) Cholesterol content, physical and sensory properties of pork from pigs fed varying levels of dietary garlic (Allium sativum). World Appl Sci J 6:971–975

    CAS  Google Scholar 

  114. 114.

    Onibi GE, Adebisi OE, Fajemisin AN, Adetunji AV (2012) Response of broiler chicken in terms of performance and meat quality to garlic (Allium sativum) supplementation. Afr J Agric Res 4:511–517

    Google Scholar 

  115. 115.

    Onu PN, Aja PM (2011) Growth performance and haematological indices of weaned rabbits fed garlic (Allium sativum) and ginger (Zingiber officinale) supplemented diets. Int J Food Agric Vet Sci 1:51–59

    Google Scholar 

  116. 116.

    Onyimonyi AE, Omeje MU (2013) Bioevaluation of garlic on growth, haematological and serum characteristics of growing pigs. Afr J Biotechnol 12:4039–4043

    CAS  Google Scholar 

  117. 117.

    Panthee A, Matsuno A, Al-Mamun M, Sano H (2017) Effect of feeding garlic leaves on rumen fermentation, methane emission, plasma glucose kinetics, and nitrogen utilization in sheep. J Anim Sci Technol 59:14. https://doi.org/10.1186/s40781-017-0139-3

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  118. 118.

    Patel RM, Garg DD, Patel VR, Vahora SG, Raval AP, Choubey M (2017) Effect of dietary supplementation of garlic (Allium sativum) and Fenugreek (Trigonella foenum-graecum L.) seed powder on growth performance, carcass characteristics and economics of feeding in broilers. J Anim Res 7:313–318

    Article  Google Scholar 

  119. 119.

    Patra AK, Kamra DN, Agarwal N (2006) Effect of plants containing secondary metabolites on in vitro methanogenesis, enzyme profile and fermentation of feed with rumen liquor of buffalo. Anim Nutr Feed Technol 6:203–213

    CAS  Google Scholar 

  120. 120.

    Patra AK, Kamra DN, Agarwal N (2009) Effects of extracts of spices on rumen methanogenesis, enzyme activities and fermentation of feeds in vitro. J Sci Food Agric 90:511–520

    Google Scholar 

  121. 121.

    Patra AK, Kamra DN, Agarwal N, Chatterjee PN (2007) Effect of Terminalia chebula and Allium sativum on rumen fermentation, enzyme activities and microbial profile in buffaloes. Indian J Anim Nutr 24:251–255

    CAS  Google Scholar 

  122. 122.

    Patra AK, Kamra DN, Bhar R, Kumar R, Agarwal N (2011) Effect of Terminalia chebula and Allium sativum on in vivo methane emission by sheep. J Anim Physiol Anim Nutr 95:187–191

    Article  CAS  Google Scholar 

  123. 123.

    Patra AK, Yu Z (2015) Effects of adaptation of in vitro rumen culture to garlic oil, nitrate, and saponin and their combinations on methanogenesis, fermentation, and abundances and diversity of microbial populations. Front Microbiol 6:1434. https://doi.org/10.3389/fmicb.2015.01434

    Article  PubMed  PubMed Central  Google Scholar 

  124. 124.

    Patterson JA, Burkholder KM (2003) Application of prebiotics and probiotics in poultry production. Poult Sci 82:627–631

    Article  CAS  PubMed  Google Scholar 

  125. 125.

    Pereira LC, Itavo LCV, Leal ES, Miraglia HH, Barbosa-Ferreira M, Carvalho CMS (2017) Evaluation of sheep fed on multinutritional blocks with garlic extract. Acta Vet Bras 11:20–28

    Article  Google Scholar 

  126. 126.

    Pirmohammadi R, Anassori E, Zakeri Z, Tahmouzi M (2014) Effects of garlic supplementation on energy status of pre-partum Mahabadigoats. Vet Res Forum 5:207–215

    PubMed  PubMed Central  Google Scholar 

  127. 127.

    Popic M (2009) Hemijski sastav belog i crnog luka. Tehnologija hrane 2:4247

    Google Scholar 

  128. 128.

    Pourali M, Kermanshahi H, Golian A, Razmi AR, Soukhtanloo M (2014) Antioxidant and anticoccidial ef-fects of garlic powder and sulfur amino acids on Eimeria-infected and uninfected broiler chickens. IJVR 15:227–232

    Google Scholar 

  129. 129.

    Pourali M, Mirghelenj SA, Kermanshahi D (2010) Effect of garlic powder on productive performance and immune response of broiler chickens challenged with Newcastle disease virus. Glob Vet 4:616–621

    CAS  Google Scholar 

  130. 130.

    Puvaca N, Ljubojevic D, Kostadinovic IJ, Lukac D, Levic J, Popovic S, Duragic O (2015) Spices and herbs in broiler nutrition: effect of garlic (Allium sativum L.) on broiler chicken production. World Poult Sci J. https://doi.org/10.1017/s0043933915002214

    Article  Google Scholar 

  131. 131.

    Qureshi AA, Abuimeileh N, Din ZZ, Elson CE, Burger WC (1983) Inhibition of cholesterol and fatty acid biosynthesis in liver enzymes and chicken hepatocytes by polar fractions of garlic. Lipids 18:343–348

    Article  CAS  PubMed  Google Scholar 

  132. 132.

    Qureshi AA, Din ZZ, Abuimeileh N, Burger WC, Ahmad Y, Elson CE (1983) Suppression of avian hepatic lipid metabolism by solvent extracts of garlic: impact on serum lipids. J Nutr 113:1746–1755

    Article  CAS  PubMed  Google Scholar 

  133. 133.

    Rahmatnejad E, Roshanfekr H, Ashayerizadeh O, Mamooee M, Ashayerizadeh A (2009) Evaluation of the effect of several non-antibiotic additives on growth performance of broiler chickens. J Anim Vet Adv 8:1670–1673

    CAS  Google Scholar 

  134. 134.

    Rahmatnejad E, Roshanfekr O, Ashayerizadeh M, Mamooee E, Ashayerizadeh A (2008) Evaluation of several non-antibiotic additive on growth performance of broiler chickens. J Anim Vet Adv 8:1670–1673

    Google Scholar 

  135. 135.

    Rasoul P, Anassori E, Zakeri Z, Tahmouzi M (2014) Effects of garlic supplementation on energy status of pre-partum Mahabadi goats. Vet Res Forum 5:207–212

    Google Scholar 

  136. 136.

    Rehman Z, Munir MT (2015) Effect of garlic on the health and performance of broilers. Veterinaria 3(1):32–39

    Google Scholar 

  137. 137.

    Roland N, Nugon-Baudon L, Andrieux C, Szylit O (1995) Comparative study of the fermentative characteristics of inulin and different types of fibre in rats inoculated with a human whole faecal flora. Brit J Nutr 74:239–249

    Article  CAS  Google Scholar 

  138. 138.

    Salih JM, Monawer AT, Abdullkahar IM (2016) Antibacterial activity of garlic against multi-drug resistant staphylococcusaureus and enterococcus faecalis in Duhok city. J Univ Duhok 19:114–122

    Google Scholar 

  139. 139.

    Shinkut M, Rekwot P, Nwannenna IA, Sambo SJ, Bugau JS, Haruna MJ (2011) Serum enzymes and histopathology of rabbit bucks fed diets supplemented with Allium sativum (Garlic). IOSR J Agric Vet Sci 9:91–95

    Google Scholar 

  140. 140.

    Shinkut M, Rekwot PI, Nwannenna IA, Bugau JS (2016) Spermiogram of rabbit bucks fed diets supplemented with Allium sativum (garlic). IOSR J Agric Vet Sci 9:20–26

    Google Scholar 

  141. 141.

    Simon PW, Jenderek MM (2003) Flowering, seed production, and the genesis of garlic breeding. Plant Breed Rev 23:211–244

    Google Scholar 

  142. 142.

    Staerfl SM, Zeitz JO, Kreuzer M, Soliva CR (2012) Methane conversion rate of bulls fattened on grass or maize silage as compared with the IPCC default values, and the long-term methane mitigation efficiency of adding acacia tannin, garlic, maca and lupine. Agric Ecosyst Environ 148:111–120

    Article  CAS  Google Scholar 

  143. 143.

    Stanacev V, Glamoi D, Milosevic N, Puvaa N, Stanacev V, Plava N (2011) Effect of garlic (Allium sativum) in fattening chicks nutrition. Afr J Agric Res 6:943–948

    Google Scholar 

  144. 144.

    Stanacev V, Miloevi N, Plavsa N, Bjedov S, Stanacev V, Puvaca N, Arapovic Ž (2010a) Phyto additives (Allium sativum L.) in the diet of fattening chickens. In: XIV Proceedings of the international symposium feed technology, Novi Sad, pp 295–301

  145. 145.

    Stanacev V, Milosevic N, Kovcun S, Plavsa N, Bjedov S, Stanacev V (2010) Effect of different garlic levels in broiler chicken food on production parameters. Contemp Agric 59:86–91

    Google Scholar 

  146. 146.

    Strickland V, Fisher J, Potts W, Hepworth G (2009) Lack of response to garlic fed at different dose rates for the control of Haemonchus contortus in Merino wether lambs. Anim Prod Sci 49:1093–1099

    Article  Google Scholar 

  147. 147.

    Tag El-Din AE, Moharam MS, Nour AA, Nasser MEA (2012) Effect of some herbs on the rumen fermentation: 1- effect of ginger (Zingiber officinale) and garlic (Allium sativum) on gas production, energy values, organic matter digestibility and methane emission, in vitro. J Agric Environ Sci Dam Univ Egypt 11:33–53

    Google Scholar 

  148. 148.

    Tao M, Chen D, Tu Y, Zhang N, Si B, Deng K, Diao Q (2016) Effect of supplementation of allicin on methanogenesis and ruminal microbial flora in Dorper crossbred ewes. J Anim Sci Biotechnol 7:1. https://doi.org/10.1186/s40104-015-0057-5

    CAS  Article  Google Scholar 

  149. 149.

    Tazi SMT, Mohamed ZMAKA, Mukhatar MA (2014) Response of broiler chicks to diets supplemented with garlic essential oil as a natural growth. Int J Sci Res 3:152–156

    Google Scholar 

  150. 150.

    Tollba AAH, Hassan MSH (2003) Using some natural additives to improve physiological and productive performance of broiler chicks under high temperature conditions. 2. Black cumin (Nigella sativa) or garlic (Allium sativum). Poult Sci 23:327–340

    Google Scholar 

  151. 151.

    Ufele AN, Ogbumuo PN (2018) Evaluation of pearl millet (Pennisetum glaucum (L.) R.BR.) and garlic meal (Allium sativum L.) on packed cell volume (PCV) of broiler chicks. Am J Zool Res 6:12–15

    Google Scholar 

  152. 152.

    Ugwuoke JI (2012) Effects of garlic (Allium sativum) and probiotics (Lactobacillus acidophilus) additives in the diets of grower pigs. MSc. Thesis, Department of Animal Science, University of Nigeria, Nsukka, pp 1–76

  153. 153.

    Upadhaya SD, Lee KY, Kim IH (2014) Protected organic acid blends as an alternative to antibiotics in finishing pigs. Asian Australas J Anim Sci 27:1600–1607

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  154. 154.

    Upadhaya SD, Lee KY, Kim IH (2016) Effect of protected organic acid blends on growth performance, nutrient digestibility and faecal micro flora in growing pigs. J Appl Anim Res 44:232–242

    Google Scholar 

  155. 155.

    Wanapat M, Kang S, Khejornsat P, Wanapat S (2013) Effects of plant herb combination supplementation on rumen fermentation and nutrient digestibility in beef cattle. Asian Australas J Anim Sci 26:1127–1136

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  156. 156.

    Wanapat M, Khejornsart P, Pakdee P, Wanapat S (2008) Effect of supplementation of garlic powder on rumen ecology and digestibility of nutrients in rumen. J Sci Food Agric 88:2231–2237

    Article  CAS  Google Scholar 

  157. 157.

    Wang JP, Yoo JS, Jang HD, Lee JH, Cho JH, Kim IH (2011) Effect of dietary fermented garlic by Weissella koreensis powder on growth performance, blood characteristics, and immune response of growing pigs challenged with Escherichia coli lipopolysaccharide. J Anim Sci 89:2023–2131

    Google Scholar 

  158. 158.

    Watt BK, Merrill AL (1963) Composition of foods—raw, processed and prepared. U.S. Government Printing Office, Washington

    Google Scholar 

  159. 159.

    Welch JJ, Watts JA, Zhang J, Vakov CR, Yao Y, Wang H et al (2004) Global regulation of erythroid gene expression by transcription factor GATA-1. Blood 104:3136–3147

    Article  CAS  Google Scholar 

  160. 160.

    Yalcin S, Onbasilar EE, Relisli Z, Yalcin S (2006) Effect of garlic powder on the performance, egg traits and blood parameters of laying hens. J Sci Food Agric 86:1335–1339

    Article  CAS  Google Scholar 

  161. 161.

    Yan L, Kim IH (2012) Effects of dietary supplementation of fermented garlic powder on growth performance, apparent total tract digestibility, blood characteristics and faecal microbial concentration in weanling pigs. J Anim Physiol Anim Nutr 97:457–464

    Article  CAS  Google Scholar 

  162. 162.

    Yan L, Meng QW, Kim IH (2011) Effects of fermented garlic powder supplementation on growth performance, nutrient digestibility, blood characteristics and meat quality in growing-finishing pigs. Anim Sci J 83:411–417

    Article  CAS  Google Scholar 

  163. 163.

    Yan L, Meng QW, Ao X, Zhou TX, Yoo JS, Kim HJ, Kim IH (2011) Effects of fermented garlic powder supplementation on growth performance, blood characteristics and meat quality in finishing pigs fed low-nutrient-density diets. Livest Sci 137:255–259

    Article  Google Scholar 

  164. 164.

    Yan L, Wang JP, Kim HJ, Meng QW, Ao X, Hong SM, Kim IH (2010) Influence of essential oil supplementation and diets with different nutrient densities on growth performance, nutrient digestibility, blood characteristics, meat quality and faecal noxious gas content in grower–finisher pigs. Livest Sci 128:115–122

    Article  Google Scholar 

  165. 165.

    Yang WZ, Benchaar C, Ametaj BN, Chaves AV, He ML, McAllister TA (2007) Effects of garlic and juniper berry essential oils on ruminal fermentation and on the site and extent of digestion in lactating cows. J Dairy Sci 90:5671–5681

    Article  CAS  Google Scholar 

  166. 166.

    Yang WZ, He ML (2016) Effects of feeding garlic and juniper berry essential oils on milk fatty acid composition of dairy cows. Nutr Metab Insights 9:19–24

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  167. 167.

    Yeh Y-Y, Liu L (2001) Cholesterol-lowering effect of garlic extracts and organosulfur compounds: human and animal studies. J Nutr 131:989–993

    Article  Google Scholar 

  168. 168.

    Zafarian R, Manafi M (2013) Effect of garlic powder on methane production, rumen fermentation and milk production of buffaloes. Annu Rev Res Biol 3:1013–1019

    CAS  Google Scholar 

  169. 169.

    Zeryehun T, Asrat M, Amha N, Urge M (2017) Effects of supplementation of different levels of garlic (Allium sativum) on selected blood profile and immunity of white leghorn chicken. Biotechnol Anim Husb 33:333–348

    Article  Google Scholar 

  170. 170.

    Zhou Z, Tan HL, Xu BX, Ma ZC, Gao Y, Wang SQ (2005) Microarray analysis of altered gene expression in diallyl trisulphide-treated HepG2 cells. Pharmacol Rep 57:818–823

    CAS  PubMed  Google Scholar 

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The first and second authors (Dr. I.P. Ogbuewu and Dr. V.M. Okoro) gathered the primary studies and developed the manuscript, while the third and fourth authors (Prof. C.A. Mbajiorgu and Prof. E.F. Mbajiorgu) reviewed the manuscript.

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Correspondence to I. P. Ogbuewu.

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Ogbuewu, I.P., Okoro, V.M., Mbajiorgu, E.F. et al. Beneficial Effects of Garlic in Livestock and Poultry Nutrition: A Review. Agric Res 8, 411–426 (2019). https://doi.org/10.1007/s40003-018-0390-y

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Keywords

  • Garlic supplementation
  • Chemical composition
  • Nutritive value
  • Livestock
  • Poultry
  • Nutrition
  • Performance