Skip to main content
SpringerLink
Log in

Unterschätztes Symptom: Häufiger und belastender als Schmerzen

Fatigue bei Palliativpatienten

  • Zertifizierte Fortbildung
  • Published:
Angewandte Schmerztherapie und Palliativmedizin

Zusammenfassung

Häufig bekommen Patienten während oder nach der Krebstherapie eine tumorassoziierte Fatigue. Besonders bei Palliativpatienten wird der Fatigue nicht genügend Aufmerksamkeit geschenkt. Dabei wirkt sich diese stärker auf die Lebensqualität aus als Schmerz oder Übelkeit und Erbrechen.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abb. 1:
Abb. 2:
Abb. 3:

Literatur

  1. Cella D et al. Cancer-Related Fatigue: Prevalence of Proposed Diagnostic Criteria in a United States Sample of Cancer Survivors. J Clin Oncol. 2001;19(14):3385–91.

    CAS  PubMed  Google Scholar 

  2. Berger AM et al. Cancer-related fatigue. J Natl Compr Canc Netw. 2010;8(8):904–31.

    PubMed  Google Scholar 

  3. Radbruch L et al. Fatigue in palliative care patients — an EAPC approach. Palliat Med. 2008;22(1):13–32.

    Article  PubMed  Google Scholar 

  4. Glaus A et al. [Fatigue in healthy and cancer patients. A qualitative study on conceptual analysis]. Pflege. 1999;12(1):11–9.

    Article  CAS  PubMed  Google Scholar 

  5. Portenoy RK, Itri LM. Cancer-Related Fatigue: Guidelines for Evaluation and Management. The Oncologist. 1999;4(1):1–10.

    CAS  PubMed  Google Scholar 

  6. Loge JH et al. Hodgkin’s Disease Survivors More Fatigued Than the General Population. J Clin Oncol. 1999;17(1):253–61.

    CAS  PubMed  Google Scholar 

  7. Tisdale MJ. Cachexia in cancer patients. Nat Rev Cancer. 2002;2(11):862–71.

    Article  CAS  PubMed  Google Scholar 

  8. Henningsen P, Martin A. [Chronic fatigue syndrome]. Dtsch Med Wochenschr. 2013;138(1–2):33–8.

    CAS  PubMed  Google Scholar 

  9. Dörr J, Nater U. [Fatigue syndromes—an overview of terminology, definitions and classificatory concepts]. Psychother Psychosom Med Psychol. 2013;63(2):69–76.

    Article  PubMed  Google Scholar 

  10. Conn VS et al. A meta-analysis of exercise interventions among people treated for cancer. Support Care Cancer. 2006;14(7):699–712.

    Article  PubMed  Google Scholar 

  11. Mortimer JE et al. Studying cancer-related fatigue: report of the NCCN scientific research committee. J Natl Compr Canc Netw. 2010;8(12):1331–9.

    PubMed  Google Scholar 

  12. Jereczek-Fossa BA et al. Fatigue During Head-And-Neck Radiotherapy: Prospective Study on 117 Consecutive Patients. Int J Radiat Oncol. 2007; 68(2):403–15.

    Article  Google Scholar 

  13. Jager A et al. The pathogenesis of cancer related fatigue: Could increased activity of pro-inflammatory cytokines be the common denominator? Eur J Cancer. 2008;44(2):175–81.

    Article  CAS  PubMed  Google Scholar 

  14. Ryan JL et al. Mechanisms of Cancer-Related Fatigue. The Oncologist. 2007;12(Suppl 1):22–34.

    Article  CAS  PubMed  Google Scholar 

  15. Peuckmann V et al. Pharmacological treatments for fatigue associated with palliative care. Cochrane Database Syst Rev. 2010;(11):CD006788.

    PubMed  Google Scholar 

  16. Minton O et al. Drug therapy for the management of cancer-related fatigue. Cochrane Database Syst Rev. 2010;(7):CD006704.

  17. Bruera E et al. Patient-controlled methylphenidate for cancer fatigue: a double-blind, randomized, placebo-controlled trial. J Clin Oncol. 2006;24(13):2073–8.

    CAS  Google Scholar 

  18. Butler JM et al. A phase III, double-blind, placebo-controlled prospective randomized clinical trial of d-threo-methylphenidate HCl in brain tumor patients receiving radiation therapy. Int J Radiat Oncol Biol Phys. 2007;69(5):1496–1501.

    Article  CAS  PubMed  Google Scholar 

  19. Escalante CP et al. A randomized, double-blind, 2-period, placebo-controlled crossover trial of a sustained-release methylphenidate in the treatment of fatigue in cancer patients. Cancer J. 2014;20(1):8–14.

    Article  CAS  PubMed  Google Scholar 

  20. Roth AJ et al. Methylphenidate for fatigue in ambulatory men with prostate cancer. Cancer. 2010;116(21):5102–10.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  21. Moraska AR et al. Phase III, randomized, double-blind, placebo-controlled study of long-acting methylphenidate for cancer-related fatigue: North Central Cancer Treatment Group NCCTG-N05C7 trial. J Clin Oncol. 2010;28(23):3673–9.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  22. Jean-Pierre P et al. A phase 3 randomized, placebo-controlled, doubleblind, clinical trial of the effect of modafinil on cancer-related fatigue among 631 patients receiving chemotherapy: a University of Rochester Cancer Center Community Clinical Oncology Program Research base study. Cancer. 2010;116(14):3513–20.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  23. Spathis A et al. Modafinil for the treatment of fatigue in lung cancer: results of a placebo-controlled, double-blind, randomized trial. J Clin Oncol. 2014;32(18):1882–8.

    Article  CAS  PubMed  Google Scholar 

  24. Yennurajalingam S et al. Reduction of cancer-related fatigue with dexamethasone: a double-blind, randomized, placebo-controlled trial in patients with advanced cancer. J Clin Oncol. 2013;31(25):3076–82.

    Article  CAS  PubMed  Google Scholar 

  25. Della Cuna GR et al. Effect of methylprednisolone sodium succinate on quality of life in preterminal cancer patients: a placebo-controlled, multicenter study. The Methylprednisolone Preterminal Cancer Study Group.} Eur J Cancer Clin Oncol. 1989;25(12):1817–21.

    Article  CAS  PubMed  Google Scholar 

  26. Semiglazov VF et al. Quality of life is improved in breast cancer patients by Standardised Mistletoe Extract PS76A2 during chemotherapy and follow-up: a randomised, placebo-controlled, double-blind, multicentre clinical trial. Anticancer Res. 2006;26(2B):1519–29.

    CAS  PubMed  Google Scholar 

  27. Wingerchuk DM et al. A randomized controlled crossover trial of aspirin for fatigue in multiple sclerosis. Neurology. 2005;64(7):1267–9.

    Article  CAS  PubMed  Google Scholar 

  28. Shaygannejad V et al. Comparison of the effect of aspirin and amantadine for the treatment of fatigue in multiple sclerosis: a randomized, blinded, crossover study. Neurol Res. 2012;34(9):854–8.

    Article  Google Scholar 

  29. Morrow GR et al. Differential effects of paroxetine on fatigue and depression: a randomized, double-blind trial from the University of Rochester Cancer Center Community Clinical Oncology Program. J Clin Oncol. 2003;21(24):4635–41.

    Article  CAS  PubMed  Google Scholar 

  30. Lacasse Y et al. Randomized trial of paroxetine in end-stage COPD. Monaldi Arch Chest Dis. 2004;61(3):140–7.

    CAS  PubMed  Google Scholar 

  31. Roscoe JA et al. Effect of paroxetine hydrochloride (Paxil) on fatigue and depression in breast cancer patients receiving chemotherapy. Breast Cancer Res Treat. 2005;89(3):243–9.

    Article  CAS  PubMed  Google Scholar 

  32. Barsevick AM et al. A pilot study examining energy conservation for cancer treatment-related fatigue. Cancer Nurs. 2002;25(5):333–41.

    Article  PubMed  Google Scholar 

  33. Thorsen L et al. Effectiveness of physical activity on cardiorespiratory fitness and health-related quality of life in young and middle-aged cancer patients shortly after chemotherapy. J Clin Oncol. 2005;23(10):2378–88.

  34. Vries DU de et al. Tumorbedingte Fatigue und ihre psychosozialen Belastungen. Internist. 2011;52(11):1317–24.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Klinik und Poliklinik für Palliativmedizin, Universitätsklinikum Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Deutschland

    Henning Cuhls

  2. http://www.springermedizin.de

    Martin Mücke, Mochamat Mochamat &  Lukash Radbruch

Authors
  1. Henning Cuhls
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Martin Mücke
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mochamat Mochamat
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Lukash Radbruch
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Henning Cuhls.

Additional information

Interessenkonflikt

Henning Cuhls, Martin Mücke und Mochamat Mochamat erklären, dass kein Interessenkonflikt besteht.

Lukas Radbruch erhielt Forschungsförderungen der Deutschen Krebshilfe sowie der Leopoldina (Deutsche Akademie der Naturforscher) und Europäische Forschungsförderungen im Rahmen des 6th & 7th Framework.

Der Verlag erklärt, dass die inhaltliche Qualität des Beitrags von zwei unabhängigen Gutachtern geprüft wurde. Werbung in dieser Zeitschriftenausgabe hat keinen Bezug zur CME-Fortbildung. Der Verlag garantiert, dass die CME-Fortbildung sowie die CME-Fragen frei sind von werblichen Aussagen und keinerlei Produktempfehlungen enthalten. Dies gilt insbesondere für Präparate, die zur Therapie des dargestellten Krankheits bildes geeignet sind.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Cuhls, H., Mücke, M., Mochamat, M. et al. Unterschätztes Symptom: Häufiger und belastender als Schmerzen. Schmerz und Palliativ 7, 28–35 (2014). https://doi.org/10.1007/s15223-014-0338-4

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s15223-014-0338-4

Search

Navigation