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Krank durch chronischen Stress

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Zusammenfassung

Chronische Anspannung kann eine anhaltende Dysregulation der physiologischen Stressreaktion und neurobiologische Konsequenzen zur Folge haben. Die Betroffenen leiden unter verschiedensten somatischen und psychiatrischen Störungen.

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Literaturverzeichnis

  1. Spranger E. Lebensformen. Geisteswissenschaftliche Psychologie und Ethik der Persönlichkeit. 8. Ausgabe. Tübingen: Niemeyer; 1950

    Google Scholar 

  2. Hemming K. Stresstheoretische Grundlagen. In: Hemming K [Hrsg.]. Freizeitaktivitäten, chronischer Stress und protektive Ressourcen: Längsschnittstudie zu hohen Leistungsanforderungen in Sport und Musik im Kindesalter. Wiesbaden: Springer; 2015

    Chapter  Google Scholar 

  3. Selye H. A syndrome produced by diverse nocuous agents. 1936. J Neuropsychiatry Clin Neurosci. 1998; 10:230–1

    Article  CAS  Google Scholar 

  4. McEwen BS. Physiology and neurobiology of stress and adaptation: central role of the brain. Physiol Rev 2007; 87:873–904

    Article  Google Scholar 

  5. McEwen BS. Protective and damaging effects of stress mediators. N Engl J Med 1998; 338:171–9

    Article  CAS  Google Scholar 

  6. Becker P, Schulz P, Schlotz W. Persönlichkeit, chronischer Stress und körperliche Gesundheit. Z Gesundheitspsychol 2004; 12:11–23

    Article  Google Scholar 

  7. Richter P, Hacker W. Belastung und Beanspruchung: Stress, Ermüdung und Burnout im Arbeitsleben. Kröning: Asanger; 2017

    Google Scholar 

  8. Mainka-Riedel M. Stressmanagement — Stabil trotz Gegenwind. Wiesbaden: Springer; 2013

    Book  Google Scholar 

  9. Fries E, Kirschbaum C. Chronischer Stress und stressbezogene Erkrankungen. In: Wippert P, Beckmann J, editors. Stress- und Schmerzursachen verstehen: Gesundheitspsychologie und -soziologie in Prävention und Rehabilitation. Stuttgart: Thieme; 2009

    Google Scholar 

  10. Lupien SJ, McEwen BS. The acute effects of corticosteroids on cognition: integration of animal and human model studies. Brain Res Rev 1997; 24:1–27

    Article  CAS  Google Scholar 

  11. Dhabhar FS. The short-term stress response — mother nature’s mechanism for enhancing protection and performance under conditions of threat, challenge, and opportunity. Front Neuroendocrinol 2018; 49:175–92

    Article  Google Scholar 

  12. Roozendaal B, Brunson KL, Holloway BL, McGaugh JL, Baram TZ. Involvement of stress-released corticotropin-releasing hormone in the basolateral amygdala in regulating memory consolidation. Proc Natl Acad Sci USA 2002; 99:13908–13

    Article  CAS  Google Scholar 

  13. Wippert P, Beckmann J, editors. Stress- und Schmerzursachen verstehen: Gesundheitspsychologie und -soziologie in Prävention und Rehabilitation. Stuttgart: Thieme; 2009

    Google Scholar 

  14. Dragoş D, Tănăsescu MD. The effect of stress on the defense systems. J Med Life 2010; 3:10–8

    PubMed  PubMed Central  Google Scholar 

  15. Chrousos GP. Stress and disorders of the stress system. Nat Rev Endocrinol 2009; 5:374–81

    Article  CAS  Google Scholar 

  16. Lupien SJ, McEwen BS, Gunnar MR, Heim C. Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nat Rev Neurosci 2009; 10:434–45

    Article  CAS  Google Scholar 

  17. Joëls M, Karst H, Krugers HJ, Lucassen PJ. Chronic stress: implications for neuronal morphology, function and neurogenesis. Front Neuroendocrinol 2007; 28:72–96

    Article  Google Scholar 

  18. Seckl JR, Meaney MJ. Glucocorticoid programming. Ann N Y Acad Sci 2004; 1032:63–84

    Article  CAS  Google Scholar 

  19. Cratty MS, Ward HE, Johnson EA, Azzaro AJ, Birkle DL. Prenatal stress increases corticotropin-releasing factor (CRF) content and release in rat amygdala minces. Brain Res 1995; 675:297–302

    Article  CAS  Google Scholar 

  20. Lemaire V, Koehl M, Le Moal M, Abrous DN. Prenatal stress produces learning deficits associated with an inhibition of neurogenesis in the hippocampus. Proc Natl Acad Sci USA 2000; 97:11032–7

    Article  CAS  Google Scholar 

  21. Piazza PV, Le Moal ML. Pathophysiological basis of vulnerability to drug abuse: role of an interaction between stress, glucocorticoids, and dopaminergic neurons. Annu Rev Pharmacol Toxicol 1996; 36:359–78

    Article  CAS  Google Scholar 

  22. O’Connor TG, Ben-Shlomo Y, Heron J, Golding J, Adams D, Glover V. Prenatal anxiety predicts individual differences in cortisol in pre-adolescent children. Biol Psychiatry 2005; 58:211–7

    Article  Google Scholar 

  23. Trautman PD, Meyer-Bahlburg HF, Postelnek J, New MI. Effects of early prenatal dexamethasone on the cognitive and behavioral development of young children: results of a pilot study. Psychoneuroendocrinology 1995; 20:439–49

    Article  CAS  Google Scholar 

  24. O’Donnell S, Noseworthy MD, Levine B, Dennis M. Cortical thickness of the frontopolar area in typically developing children and adolescents. Neuroimage 2005; 24:948–54

    Article  Google Scholar 

  25. Avital A, Richter-Levin G. Exposure to juvenile stress exacerbates the behavioural consequences of exposure to stress in the adult rat. Int J Neuropsychopharmacol 2005; 8:163–73

    Article  Google Scholar 

  26. Cohen RA, Grieve S, Hoth KF, Paul RH, Sweet L, Tate D, et al. Early life stress and morphometry of the adult anterior cingulate cortex and caudate nuclei. Biol Psychiatry 2006; 59:975–82

    Article  Google Scholar 

  27. Fischer AS, Camacho MC, Ho TC, Whitfield-Gabrieli S, Gotlib IH. Neural markers of resilience in adolescent females at familial risk for major depressive disorder. JAMA Psychiatry 2018; 75:493–502

    Article  Google Scholar 

  28. Bolsinger J, Seifritz E, Kleim B, Manoliu A. Neuroimaging correlates of resilience to traumatic events — a comprehensive review. Front Psychiatry 2018; 9:693

    Article  Google Scholar 

  29. Raskind MA, Peskind ER, Wilkinson CW. Hypothalamic-pituitary-adrenal axis regulation and human aging. Ann N Y Acad Sci 1994; 746:327–35.

    Article  CAS  Google Scholar 

  30. Dai J, Buijs R, Swaab D. Glucocorticoid hormone (cortisol) affects axonal transport in human cortex neurons but shows resistance in Alzheimer’s disease. Br J Pharmacol 2004; 143:606–10

    Article  CAS  Google Scholar 

  31. Seeman TE, McEwen BS, Rowe JW, Singer BH. Allostatic load as a marker of cumulative biological risk: MacArthur studies of successful aging. Proc Natl Acad Sci USA 2001; 98:4770–5

    Article  CAS  Google Scholar 

  32. Karlamangla AS, Singer BH, McEwen BS, Rowe JW, Seeman TE. Allostatic load as a predictor of functional decline. J Clin Epidemiol 2002; 55:696–710

    Article  Google Scholar 

  33. Mikhail A. Stress: a psychophysiological conception. J Human Stress 1981; 7:9–15

    Article  CAS  Google Scholar 

  34. Southwick SM, Charney DS. The science of resilience: implications for the prevention and treatment of depression. Science 2012; 338:79–82

    Article  CAS  Google Scholar 

  35. Noeker M, Petermann F. Resilienz: Funktionale Adaptation an widrige Umgebungsbedingungen. Z Psychiatr Psych Ps 2008; 56:255–63

    Google Scholar 

  36. Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, Lanas F, et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. The Lancet 2004; 364:937–52

    Article  Google Scholar 

  37. Tang A, O’Sullivan AJ, Diamond T, Gerard A, Campbell P. Psychiatric symptoms as a clinical presentation of Cushing’s syndrome. Ann Gen Psychiatry 2013; 12:23

    Article  Google Scholar 

  38. Margraf J, Schneider S. Lehrbuch der Verhaltenstherapie. Berlin, Heidelberg: Springer; 2009

    Book  Google Scholar 

  39. Bosch OG, Seifritz E, Wetter TC. Stress-related depression: neuroendocrine, genetic, and therapeutical aspects. World J Biol Psychiatry 2012; 13:556–68

    Article  Google Scholar 

  40. Kessler RC. The effects of stressful life events on depression. Annu Rev Psychol 1997; 48:191–214

    Article  CAS  Google Scholar 

  41. Klengel T, Pape J, Binder EB, Mehta D. The role of DNA methylation in stress-related psychiatric disorders. Neuropharmacology 2014; 80:115–32

    Article  CAS  Google Scholar 

  42. Vreeburg SA, Hoogendijk WJG, van Pelt J, Derijk RH, Verhagen JCM, van Dyck R, et al. Major depressive disorder and hypothalamic-pituitary-adrenal axis activity: results from a large cohort study. Arch Gen Psychiatry 2009; 66:617–26

    Article  CAS  Google Scholar 

  43. Ströhle A, Holsboer F. Stress responsive neurohormones in depression and anxiety. Pharmacopsychiatry 2003; 36 Suppl 3:S207–14

    PubMed  Google Scholar 

  44. Pariante CM, Lightman SL. The HPA axis in major depression: classical theories and new developments. Trends Neurosci 2008; 31:464–8

    Article  CAS  Google Scholar 

  45. Schmaal L, Veltman DJ, van Erp TGM, Sämann PG, Frodl T, Jahanshad N, et al. Subcortical brain alterations in major depressive disorder: findings from the ENIGMA Major Depressive Disorder working group. Mol Psychiatry 2016; 21:806–12

    Article  CAS  Google Scholar 

  46. Seligman F, Nemeroff CB. The interface of depression and cardiovascular disease: therapeutic implications. Ann N Y Acad Sci 2015; 1345:25–35

    Article  CAS  Google Scholar 

  47. Brouwer JP, Appelhof BC, van Rossum EFC, Koper JW, Fliers E, Huyser J, et al. Prediction of treatment response by HPA-axis and glucocorticoid receptor polymorphisms in major depression. Psychoneuroendocrinology 2006; 31:1154–63

    Article  CAS  Google Scholar 

  48. Barden N. Implication of the hypothalamic-pituitary-adrenal axis in the physiopathology of depression. J Psychiatry Neurosci 2004; 29:185–93

    PubMed  PubMed Central  Google Scholar 

  49. Holsboer F. Stress, hypercortisolism and corticosteroid receptors in depression: implicatons for therapy. J Affect Disord 2001; 62:77–91

    Article  CAS  Google Scholar 

  50. Jacobs GD. Clinical applications of the relaxation response and mind-body interventions. J Altern Complement Med 2001; 7 Suppl 1:S93–101

    Article  Google Scholar 

  51. Grossman P, Niemann L, Schmidt S, Walach H. Mindfulness-based stress reduction and health benefits. J Psychosom Res 2004; 57:35–43

    Article  Google Scholar 

  52. Hofmann SG, Gómez AF. Mindfulness-Based Interventions for Anxiety and Depression. Psychiatr Clin North Am 2017; 40:739–49

    Article  Google Scholar 

  53. Sonnenschein M, Mommersteeg PMC, Houtveen JH, Sorbi MJ, Schaufeli WB, van Doornen LJP. Exhaustion and endocrine functioning in clinical burnout: an in-depth study using the experience sampling method. Biol Psychol 2007; 75:176–84

    Article  Google Scholar 

  54. Vente W de, van Amsterdam JGC, Olff M, Kamphuis JH, Emmelkamp PMG. Burnout is associated with reduced parasympathetic activity and reduced HPA axis responsiveness, predominantly in males. Biomed Res Int 2015; 2015:431725

    Article  Google Scholar 

  55. Mommersteeg PMC, Heijnen CJ, Verbraak MJPM, van Doornen LJP. Clinical burnout is not reflected in the cortisol awakening response, the day-curve or the response to a low-dose dexamethasone suppression test. Psychoneuroendocrinology 2006; 31:216–25

    Article  CAS  Google Scholar 

  56. Ahola K, Honkonen T, Isometsä E, Kalimo R, Nykyri E, Aromaa A, Lönnqvist J. The relationship between job-related burnout and depressive disorders — results from the Finnish Health 2000 Study. J Affect Disord 2005; 88:55–62

    Article  Google Scholar 

  57. Maslach C, Schaufeli WB, Leiter MP. Job burnout. Annu Rev Psychol 2001; 52:397–422

    Article  CAS  Google Scholar 

  58. Nil R, Jacobshagen N, Schächinger H, Baumann P, Höck P, Hättenschwiler J, et al. Burnout — eine Standortbestimmung. Swiss Arch Neurol Psychiatr 2010; 161:71–6

    Article  Google Scholar 

  59. Maslach C, Jackson SE. The measurement of experienced burnout. J Organ Behav 1981; 2:99–113

    Article  Google Scholar 

  60. Känel R von. Das Burnout-Syndrom: eine medizinische Perspektive. Praxis 2008; 97:477–87

    Article  Google Scholar 

  61. Holsboer-Trachsler E, Hättenschwiler JA, Beck J, Brand S, Hemmeter UM, Keck ME, et al. Die Akutbehandlung depressiver Episoden. Swiss Med Forum 2016; 16:716–24

    Google Scholar 

  62. Holsboer-Trachsler E, Hättenschwiler JA, Beck J, Brand S, Hemmeter UM, Keck ME, et al. Erhaltungstherapie und Rezidivprophylaxe unipolarer depressiver Störungen. Swiss Med Forum 2016; 16:739–43

    Google Scholar 

  63. Meichenbaum D. Intervention bei Stress: Anwendung und Wirkung des Stressimpfungstrainings. 3rd ed. Bern: Huber; 2012

    Google Scholar 

  64. Kaluza G. Stressbewältigung. Berlin, Heidelberg: Springer; 2011

    Book  Google Scholar 

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Authors and Affiliations

  1. Klinik für Psychiatrie, Psychotherapie und Psychosomatik, Psychiatrische Universitätsklinik Zürich, Lenggstraße 31, 8032, Zürich, Schweiz

    Rainer Krähenmann &  Erich Seifritz

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  1. Rainer Krähenmann
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  2. Erich Seifritz
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Correspondence to Rainer Krähenmann.

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Krähenmann, R., Seifritz, E. Krank durch chronischen Stress. DNP 20, 38–48 (2019). https://doi.org/10.1007/s15202-019-2113-z

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