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Phase-II-Studie zur Malariatherapie

Monoklonaler Antikörper zur Behandlung der P.-falciparum-bedingten Malaria

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Literatur

  1. RTS,S Clinical Trials Partnership. Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial. Lancet. 2015;386:31-45

  2. Sissoko MS, Healy SA, Katile A et al. Safety and efficacy of a three-dose regimen of Plasmodium falciparum sporozoite vaccine in adults during an intense malaria transmission season in Mali: a randomised, controlled phase 1 trial. Lancet Infect Dis. 2022;22:377-89

  3. Alonso PL, Sacarlal J, Aponte JJ et al. Efficacy of the RTS,S/AS02A vaccine against Plasmodium falciparum infection and disease in young African children: randomised controlled trial. Lancet. 2004;364:1411-20

  4. Polhemus ME, Remich SA, Ogutu BR et al. Evaluation of RTS,S/AS02A and RTS,S/AS01B in adults in a high malaria transmission area. PLoS One. 2009;4(7):e6465

  5. Bojang KA, Milligan PJ, Pinder M et al. Efficacy of RTS,S/AS02 malaria vaccine against Plasmodium falciparum infection in semi-immune adult men in the Gambia: a randomised trial. Lancet. 2001;358:1927-34

  6. Wang LT, Pereira LS, Flores-Garcia Y et al. A potent anti-malarial human monoclonal antibody targets circumsporozoite protein minor repeats and neutralizes sporozoites in the liver. Immunity. 2020;53(4):733.e8-744.e8

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Authors and Affiliations

  1. Medizinische Klinik III, Kreiskliniken Reutlingen, Steinenbergstraße 31, 72764, Reutlingen, Deutschland

    Adrian Gillissen

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  1. Adrian Gillissen
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Correspondence to Adrian Gillissen.

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Gillissen, A. Monoklonaler Antikörper zur Behandlung der P.-falciparum-bedingten Malaria. Pneumo News 15, 25–26 (2023). https://doi.org/10.1007/s15033-022-3455-3

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  • DOI: https://doi.org/10.1007/s15033-022-3455-3

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