Literatur
Lawrence MS, Stojanov P, Polak P et al. Mutational heterogeneity in cancer and the search for new cancer-associated genes. Nature. 2013;499(7457):214–8
Yarchoan M, Hopkins A, Jaffee EM. Tumor Mutational Burden and Response Rate toPD-1 Inhibition. N Engl J Med. 2017;377(25):2500–01
Ramalingam SS, Hellmann MD, Awad MM et al. Tumor mutation burden (TMB) as a biomarker for clinical benefit from dual immune checkpoint blockade with nivolumab (nivo) + ipilimumab (ipi) in first-line (1L) nonsmall cell lung cancer (NSCLC): identification of TMB cutoff from Check- Mate 568. Presented at the American Association for Cancer Research 2018 Annual Meeting, Chicago, April 16
Hellmann MD, Rizvi NA, Goldman JW et al. Nivolumab plus ipilimumab as first-line treatment foradvanced non-small-cell lung cancer (Check- Mate 012): results of an open-label, phase 1, multicohort study. Lancet Oncol. 2017;18(1):31–41
Originalie
Hellmann MD, Ciuleanu TE, Pluzanski A et al. Nivolumab plus Ipilimumab in Lung Cancer with a High Tumor Mutational Burden. N Engl J Med. 2018;378(22):2093–104
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Hammerschmidt, S. Immun-Kombi schlägt Chemotherapie bei NSCLC mit hoher Mutationslast. Pneumo News 10, 21–22 (2018). https://doi.org/10.1007/s15033-018-0977-9
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DOI: https://doi.org/10.1007/s15033-018-0977-9